Pharmaceutical composition for peroral administration of 3,3'-diindolylmethane

Abstract

Block copolymer pharmaceutical compositions containing 3,3′-diindolylmethane (DIM). The pharmaceutical composition for peroral administration comprises 3,3′-diindolylmethane as an active component and a target additive, the target additive being a block copolymer of oxyethylene and oxypropylene, in which the content of the hydrophobic oxypropylene block is less than 50 mass % and the molecular mass of the hydrophilic oxyethylene block is equal to 2,250 Da or more, at a ratio of the active component to the selected block copolymer varying between 1:2 and 1:10. The composition improves absorption of the active compound by the bloodstream upon peroral delivery.

1 . A pharmaceutical composition for peroral administration containing 3,3′-diindolylmethane as an active component and a target additive, further comprising a block copolymer of oxyethylene and oxypropylene as the target additive, wherein the content of the hydrophobic block is less than 50 mass % and the molecular mass of the hydrophilic block is 2,250 Da or more at a ratio of the active component to the selected block copolymer varying between 10:1 and 2:1. 
     
     
         2 . The pharmaceutical composition as claimed in  claim 1 , further containing Pluronic F127 as a block copolymer of oxyethylene and oxypropylene. 
     
     
         3 . The pharmaceutical composition as claimed in  claim 2 , further containing Pluronic L10 as well. 
     
     
         4 . The pharmaceutical composition as claimed in  claim 1 , further containing a pharmaceutically acceptable carrier. 
     
     
         5 . The pharmaceutical composition as claimed in  claim 4 , said composition being in the form of a tablet, lyophilized powder, suspension, or capsule.