Spirocyclic Cyclohexane Compounds Useful To Treat Substance Dependency

Abstract

Spirocyclic cyclohexane compounds useful in pharmaceutical compositions for use in the treatment of substance dependency.

1 - 22 . (canceled) 
     
     
         23 . A method of treating opioid dependency in a patient, said method comprising administering to said patient an effective amount of 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole in the form of a pure stereoisomer or a mixture of stereoisomers in any mixing ratio, or a physiologically acceptable salt thereof. 
     
     
         24 . The method according to  claim 23 , wherein 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole or the physiologically acceptable salt thereof is in the form of a pure enantiomer or diastereomer. 
     
     
         25 . The method according to  claim 23 , wherein the 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole or the physiologically acceptable salt thereof is in the form of a racemate. 
     
     
         26 . The method according to  claim 23 , wherein the opioid dependency is heroin, morphine or methadone dependency. 
     
     
         27 . The method according to  claim 23 , wherein 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole is used in combination with naloxone. 
     
     
         28 . The method according to  claim 23 , wherein the 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole is present in the form of its hydrochloride, citrate, methane sulfonate or hemicitrate. 
     
     
         29 . The method according to  claim 23 , wherein 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole is used in the form of the free base. 
     
     
         30 . The method according to  claim 23 , wherein 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole is present in the form of the non-polar diastereomer. 
     
     
         31 . The method according to  claim 23 , wherein 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole is present in the form of the non-polar diastereomer of the free base. 
     
     
         32 . The method according to  claim 23 , wherein 1,1-(3-dimethylamino-3-phenylpenta-methylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole is present in the form of the non-polar diastereomer of the free base and the opioid dependency is heroin, morphine or methadone dependency.