Diagnosis and Monitoring of Renal Failure Using Peptide Biomarkers

Abstract

Methods for the determination of renal failure, especially chronic renal failure and acute kidney injury, by measurement of peptide or protein biomarkers are described. The methods are useful to determine stages of renal failure, especially the early stages such as stage 1, 2, and 3 of chronic renal failure and stages R and I of acute kidney injury. Furthermore there are described peptides and test kits used in the invention. The described methods are intended to replace or complement the measurement of creatinine and/or cystatin C and/or NGAL for diagnosis of renal failure.

We claim: 
     
         1 . A peptide biomarker consisting of SEQ ID NO: 2. 
     
     
         2 . A kit for diagnosing, monitoring the progression or monitoring the treatment of a renal disorder, comprising:
 a. a peptide biomarker consisting of SEQ ID NO: 2; and   b. instructions to detect said biomarker in a biological sample.