US2014294948A1PendingUtilityA1

Composition as auxiliary means for oral medication

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Assignee: PAXTREE LTDPriority: Apr 2, 2013Filed: Apr 2, 2014Published: Oct 2, 2014
Est. expiryApr 2, 2033(~6.7 yrs left)· nominal 20-yr term from priority
Inventors:Ron Bruijns
A61K 9/0056A61K 31/194A61K 9/06A23L 29/256A61K 47/36A23L 29/35A61K 9/0053A61K 47/02A61K 47/12A61K 47/26
59
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Claims

Abstract

The invention relates in one aspect to a composition, specifically a jelly, the use of which composition as an auxiliary means is to ease the taking of oral medication in solid form, which composition comprises iota-carrageenan as a jellifying agent and citric acid as a salivating agent, characterized in that the composition further comprises maltodextrin. In another aspect, the composition comprises a calcium sequestrant for adjusting Ca-ion activity of the composition. In one embodiment, the composition comprises iota-carrageenan in 0.7-1.0% in mass, citric acid in 0.06-0.07% in mass, maltodextrin in 1.5% in mass, all relative to the total mass of the composition, and an amount of a calcium sequestrant such that the Ca-ion activity of the composition is between 20 ppm and 80 ppm.

Claims

exact text as granted — not AI-modified
1 . A composition in the form of a jelly, comprising iota-carrageenan, citric acid and maltodextrin, wherein the amount of maltodextrin in the composition is in the range of 1.3-1.8% in mass of the total mass of the composition. 
     
     
         2 . A composition according to  claim 1 , characterized in that the amount of maltodextrin in the composition is 1.5% in mass of the total mass of the composition. 
     
     
         3 . A composition according to  claim 1 , characterized in that the composition comprises citric acid in 0.05 to 0.10% in mass of the total mass of the composition. 
     
     
         4 . A composition according to  claim 3 , characterized in that the composition comprises citric acid in 0.06% in mass of the total mass of the composition. 
     
     
         5 . A composition according to  claim 1 , characterized in that the amount of citric acid comprised in the composition is such that the pH of the composition lies in the range of 4.8 to 6.5. 
     
     
         6 . A composition according to  claim 5 , characterized in that the amount of citric acid comprised in the composition is such that the pH of the composition lies in the range of 5.0 to 6.0. 
     
     
         7 . A composition according to  claim 5 , characterized in that the amount of citric acid comprised in the composition is such that the pH of the composition is 5.5. 
     
     
         8 . A composition according to  claim 1 , characterized in that the composition further comprises a calcium sequestrant for adjusting Ca-ion activity of the composition. 
     
     
         9 . A composition according to  claim 8 , characterized in that the composition comprises an amount of a calcium sequestrant such that the Ca-ion activity of the composition is <500 ppm. 
     
     
         10 . A composition according to  claim 9 , characterized in that the composition comprises an amount of a calcium sequestrant such that the Ca-ion activity of the composition is between 10 ppm and 100 ppm. 
     
     
         11 . A composition according to  claim 10 , characterized in that the composition comprises an amount of a calcium sequestrant such that the Ca-ion activity of the composition is between 20 ppm and 80 ppm. 
     
     
         12 . A composition according to  claim 9 , characterized in that the calcium sequestrant comprised in the composition is calcium chloride. 
     
     
         13 . A composition according to  claim 9 , characterized in that the sequestrant comprised in the composition is calcium carbonate. 
     
     
         14 . A composition according to  claim 12 , characterized in that the amount of calcium chloride comprised in the composition is lower than 0.4% in mass relative to the total mass of the composition. 
     
     
         15 . A composition according to  claim 12 , characterized in that the amount of calcium chloride comprised in the composition is 0.005-0.015% in mass relative to the total mass of the composition. 
     
     
         16 . A composition according to  claim 1 , characterized in that the storage modulus G′ is greater than the loss modulus G″ and that the relationship between the two modules (G′ and G″) expressed as the formula tangent delta=G″/G′ is lower than 1 for a frequency range of 0.1-80 s −1 , more preferably 0.1-100 s −1 . 
     
     
         17 . A composition according to  claim 16 , characterized in that the value of the tangent delta increases relative to the increase of the frequency. 
     
     
         18 . A composition according to  claim 1 , characterized in that the iota-carrageenan is comprised in an amount of 0.5 to 2% in mass of the total mass of the composition. 
     
     
         19 . A composition according to  claim 18 , characterized in that the iota-carrageenan is comprised in an amount of 0.7 to 1.0% in mass of the total mass of the composition. 
     
     
         20 . A composition according to  claim 1 , characterized in that the composition comprises water in an amount of 80-99% in mass of the total mass of the composition. 
     
     
         21 . A composition according to  claim 1 , characterized in that the composition comprises water in an amount of 84-97% in mass of the total mass of the composition. 
     
     
         22 . A composition according to  claim 1 , characterized in that the composition has a yield stress of 15 Pa or higher at 20° C. 
     
     
         23 . A composition according to  claim 22 , characterized in that the composition has a yield stress in the range of 35-50 Pa at 20° C. 
     
     
         24 . A composition according to  claim 1 , characterized in that it further comprises a preservating agent. 
     
     
         25 . A composition according to  claim 24 , characterized in that the preservating agent is potassium sorbate or sodium benzoate. 
     
     
         26 . A composition according to  claim 24 , characterized in that the preservative is potassium sorbate comprised in an amount of 0.2-1.0% in mass, preferably 0.4-0.8% in mass, and more preferably 0.6-0.8% in mass, of the total mass of the composition. 
     
     
         27 . A composition according to  claim 1 , characterized in that it comprises a flavouring agent. 
     
     
         28 . A composition according to  claim 27 , characterized in the flavouring agent provides one of the following flavours: orange, lemon, lime, red fruit and mint. 
     
     
         29 . A composition according to  claim 27 , characterized in that the flavouring agent is comprised in an amount of 0.05-0.20% in mass, preferably 0.07-0.10% in mass, of the total mass of the composition. 
     
     
         30 . A composition according to  claim 1 , characterized in that the composition comprises a sweetening agent chosen from the group of: saccharose, aspartame, sucralose, stevia, inuline and derivatives thereof. 
     
     
         31 . A composition according to  claim 30 , characterized in that the sweetening agent is saccharose that is comprised in an amount of 12-13% in mass of the total mass of the composition. 
     
     
         32 . A composition according to  claim 30 , characterized in that the sweetening agent is aspartame that is comprised in an amount of 0.03-0.06% in mass of the total mass of the composition. 
     
     
         33 . A composition according to  claim 1 , characterized by the absence of hydroxypropyl methylcellulose, gelatin, spilanthol, jambu oleoresin or agar. 
     
     
         34 . A composition according to  claim 1 , characterized by the absence of carob, carboxy methylcellulose or xanthan gum. 
     
     
         35 . A composition according to  claim 1 , characterized in that it does not comprise any active therapeutic or prophylactic substance. 
     
     
         36 . A composition according to  claim 1 , comprising 0.8% iota-carrageenan, 0.06-0.07% citric acid, 1.5% maltodextrin and 0.005% calcium chloride, all percentages in mass relative to the total mass of the composition. 
     
     
         37 . A composition in the form of a jelly, comprising iota-carrageenan, citric acid and maltodextrin and 0.005-0.4% in mass, preferably 0.005-0.015% in mass, of calcium chloride relative to the total mass of the composition. 
     
     
         38 . A method of use of a composition according to  claim 1  as an auxiliary means for easing the taking of oral medication in solid form, comprising a step of coating the medication in the form of a pill, capsule or tablet followed by a step of swallowing the thus coated medication. 
     
     
         39 . A method of use of a composition according to  claim 1 , as an auxiliary means for easing the taking of oral medication in solid form, characterized in that the composition and the medication to be swallowed can be introduced either separately and in any order, or simultaneously, into a mouth.

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