Anti-tumoural effects of cannabinoid combinations

Abstract

The invention relates to the use of a combination of cannabinoids, particularly tetrahydrocannabinol (THC) and cannabidiol (CBD), in the manufacture of a medicament for use in the treatment of cancer. In particular the cancer to be treated is a brain tumour, more particularly a glioma, more particularly still a glioblastoma multiforme (GBM).

1 - 12 . (canceled) 
     
     
         13 . A method for treating a brain tumour comprising administering to a patient having a brain tumour, a combination of cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD), wherein the CBD is present in an amount by weight that is greater than the amount by weight of THC. 
     
     
         14 . The method of  claim 13 , wherein the cannabinoid content is in the range of between 5 and 100 mg of the total cannabinoids present. 
     
     
         15 . The method of  claim 13 , where each cannabinoid is used at a level which would be considered sub-optimal if being used alone. 
     
     
         16 . The method of  claim 13 , wherein the brain tumour is a glioma tumour. 
     
     
         17 . The method of  claim 16 , wherein the brain tumour is a glioblastoma multiforme (GBM). 
     
     
         18 . The method of  claim 13 , wherein the THC and CBD are present as plant extracts, as pure compounds, or a combination of the two. 
     
     
         19 . The method of  claim 18 , wherein the plant extract is in the form of a botanical drug substance. 
     
     
         20 . The method of  claim 13 , wherein the THC and CBD are administered separately, sequentially or simultaneously to one another.