System and stent for repairing endovascular defects and methods of use

Abstract

Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and/or repair damaged vessels.

What is claimed is: 
     
         1 . A stent comprising a coating on a portion of its surface for use in the treatment of a cerebral aneurysm, the coating comprising:
 a magnetic material deposited on portion of an outer surface of the stent;   an ion-beam nanostructured biocompatible layer; and   a bioactive layer formed on the biocompatible layer, the bioactive layer comprising PCSM.   
     
     
         2 . The stent of  claim 2 , further comprising an underlayer between the outer surface of the stent and the magnetic material. 
     
     
         3 . The stent of any one of  claim 1  or  2 , wherein the magnetic material is selected from a magnetic metal layer and a polymer impregnated with a magnetic metal. 
     
     
         4 . The stent of  claim 4 , wherein the metal is nickel. 
     
     
         5 . The stent of  claim 4 , wherein the polymer is bacterial nanocellulose. 
     
     
         6 . The stent of any of  claims 1 - 5 , further comprising nanoscale particles embedded in the coating to provide radiation-enhanced tomography for visualization of the stent surface. 
     
     
         7 . A system for delivering a stent to a cerebral artery having an aneurysm comprising an endovascular catheter and the stent of any one of  claims 1 - 6 . 
     
     
         8 . The system of  claim 7 , further comprising magnetized cells. 
     
     
         9 . The system of  claim 8 , wherein the magnetized cells are endothelial cells. 
     
     
         10 . A method of repairing a cerebral artery and/or occluding an aneurysm comprising:
 delivering the stent of any one of  claims 1 - 6  to the artery such that the portion of the stent comprising the coating is proximal to the aneurysm neck in need of repair and/or occlusion.   
     
     
         11 . The method of  claim 10 , further comprising delivering magnetized cells to the region of the artery in need of repair. 
     
     
         12 . The method of  claim 10  or  11 , wherein the stent is delivered to the artery in need of repair by catheterization.