Tissue scaffolds derived from forestomach extracellular matrix

Abstract

The present invention pertains to the development of Extracellular Matrix (ECM) scaffolds derived from the forestomach of a ruminant. Such scaffolds are useful in many clinical and therapeutic applications, including wound repair, tissue regeneration, and breast reconstruction. In addition, the present invention features methods of isolating ECM scaffolds from mammalian organs, including but not limited to the ruminant forestomach. The invention further features laminated ECM scaffolds containing a polymer positioned between individual ECM sheets. The polymer may optionally contain bioactive molecules to enhance the functionality of the scaffold.

What is claimed: 
     
         1 . An implantable tissue scaffold device for supporting breast tissue within a patient, wherein said device comprises extracellular matrix of the propria-submucosa of the forestomach of a ruminant. 
     
     
         2 . The device of  claim 1 , wherein the breast tissue comprises a prosthesis. 
     
     
         3 . The device of  claim 1 , formatted as a laminated sheet comprising two or more layers of extracellular matrix. 
     
     
         4 . The device of  claim 3 , wherein the laminated sheet comprises 4-8 layers of extracellular matrix. 
     
     
         5 . The device of  claim 1 , which has concavity. 
     
     
         6 . The device of  claim 3 , wherein the layers of extracellular matrix are secured together by stitches or sutures. 
     
     
         7 . The device of  claim 1 , wherein the extracellular matrix is perforated. 
     
     
         8 . The device of  claim 1 , wherein the extracellular matrix is unperforated. 
     
     
         9 . The device of  claim 1 , wherein the device has a crescent shape. 
     
     
         10 . The device of  claim 1 , wherein the device has an elliptical shape. 
     
     
         11 . A method of supporting breast tissue within a patient, comprising positioning the device of  claim 1  within the patient in a supporting position relative to the breast tissue. 
     
     
         12 . The method of  claim 11 , wherein the breast tissue comprises a breast prosthesis. 
     
     
         13 . The method of  claim 11 , wherein the breast tissue comprises native tissue. 
     
     
         14 . The method of  claim 11 , wherein said positioning comprises covering the lower and lateral sections of the breast tissue.