Extract and peptides derived from oryza sativa japonica group and uses thereof

Abstract

The invention relates to isolated peptides derived from Oryza sativa Japonica Group, pharmaceutical compositions comprising same, and uses thereof for treating, preventing, ameliorating, and/or delaying the onset of inflammatory and/or neuroinflammatory and/or autoimmune diseases or conditions and in particular multiple sclerosis. The invention further relates to extracts from Oryza sativa Japonica Group and use thereof as a dietary supplement or in a pharmaceutical composition for treating, preventing, ameliorating, and/or delaying the onset of inflammatory, and/or inflammatory, neuroinflammatory and/or autoimmune diseases or conditions. The peptides and the extract of the invention may be used for treating, ameliorating, and/or delaying the onset or preventing multiple sclerosis.

1 . A method of treating, ameliorating, preventing or delaying the onset of multiple sclerosis in a subject comprising the step of administering to the subject a therapeutically effective amount of a composition comprising a peptide that comprises an amino acid sequence AEMIDLAAKMLSEGRG as set forth in SEQ ID NO: 1. 
     
     
         2 . The method of  claim 1 , wherein said composition is a pharmaceutical composition, an extract, or a dietary supplement. 
     
     
         3 . The method of  claim 1 , wherein said peptide is derived from  Oryza sativa  Japonica Group. 
     
     
         4 . The method of  claim 1 , wherein the amount of said peptide is between 1 fg/g to 1 mg/g. 
     
     
         5 . The method of  claim 2 , wherein said extract is further enriched by an exogenous peptide comprising the amino acid sequence AEMIDLAAKMLSEGRG as set forth in SEQ ID NO:1. 
     
     
         6 . A method of treating, ameliorating, preventing or delaying the onset of multiple sclerosis in a subject comprising the step of administering to the subject a therapeutically effective amount of a composition comprising a peptide consisting of an amino acid sequence AEMIDLAAKMLSEGRG as set forth in SEQ ID NO: 1. 
     
     
         7 . The method of  claim 6 , wherein said composition is a pharmaceutical composition, an extract, or a dietary supplement. 
     
     
         8 . The method of  claim 6 , wherein said peptide is derived from  Oryza sativa  Japonica Group. 
     
     
         9 . The method of  claim 6 , wherein the amount of said peptide is between 1 fg/g to 1 mg/g. 
     
     
         10 . The method of  claim 7 , wherein said extract is further enriched by an exogenous peptide comprising the amino acid sequence AEMIDLAAKMLSEGRG as set forth in SEQ ID NO:1.