Use of Tiliacora Triandra in Cosmetics and Compositions Thereof

Abstract

The present disclosure relates to compositions for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, where the compositions include natural plant constituents which increase expression levels genes, collagen replacement and retention, and cell proliferation of epidermis and dermis associated with the dermatological signs of aging. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof, once daily in an amount effective in improving the condition and aesthetic appearance of skin.

1 . A topical composition comprising:
 (a) a  Tiliacora triandra  Diels plant extract present in an amount sufficient to affect at least one of increased fibroblast proliferation; increased keratinocyte proliferation, reduced collagenase activity; or increased expression of collagen; and   (b) a cosmetically or physiologically acceptable vehicle, with the proviso that the composition does not contain iodine.   
     
     
         2 . The composition of  claim 1 , wherein the plant extract is from a vine of  Tiliacora triandra  Diels. 
     
     
         3 . The composition of  claim 2 , wherein the extract is a concentrate. 
     
     
         4 . The composition of  claim 2 , wherein the extract is dried. 
     
     
         5 . The composition of  claim 2 , wherein the plant extract is obtained by (i) extraction with an organic solvent; (ii) extraction with a solvent mixture comprising a polar organic solvent and water, or (iii) extraction with acidic or alkaline pH water for 1 to about 8 hours at a temperature of from about 30° to 90° C. 
     
     
         6 . The composition of  claim 5 , wherein the plant extract is obtained by extraction with the organic solvent (i) for about 1 to about 8 hours at a temperature of about 30° to 90 C. 
     
     
         7 . The composition of  claim 6 , wherein the organic solvent is hexane. 
     
     
         8 . The composition of  claim 7 , wherein the plant extract is dried. 
     
     
         9 . The composition of  claim 5 , wherein the plant extract is obtained by extraction with the solvent mixture (ii) for about 1 to about 8 hours at a temperature of about 30° to 90° C., and wherein the polar organic solvent is selected from the group consisting of C 1  to C 6  alcohols, glycols, ethers, esters, ketones, and compatible mixtures thereof. 
     
     
         10 . The composition of  claim 9 , wherein the polar organic solvent is ethanol present in an amount of from about 40% by volume to about 90% by volume, based on the total weight of the solvent mixture. 
     
     
         11 . The composition of  claim 9 , wherein the plant extract is dried. 
     
     
         12 . The composition of  claim 1 , wherein the acidic or alkaline aqueous extract (iii) is neutralized. 
     
     
         13 . The composition of  claim 12 , wherein the neutralized extract is admixed with a polar organic solvent to transfer the extract actives to an organic phase. 
     
     
         14 . The composition of  claim 1 , wherein the plant extract is present in an amount from about 0.001 wt % to about 10 wt %, based on the total weight of the composition. 
     
     
         15 . The composition of  claim 1 , wherein the plant extract is present in an amount from about 0.01 wt % to about 5 wt %, based on the total weight of the composition. 
     
     
         16 . The composition of  claim 10 , wherein the plant extract is present in an amount from about 0.05 wt % to about 1 wt %, based on the total weight of the composition. 
     
     
         17 . The composition of  claim 1  further comprising at least one skin active agent selected from the group consisting of  Abies pindrow  extract,  Acacia catechu  extract,  Anogeissus latifolia  extract,  Asmunda japonica  extract,  Azadirachta indica  extract,  Butea frondosa  extract,  Cedrus deodara  extract,  Emblica officinalis  extract,  Ficus benghalensis  extract,  Glycyrrhiza glabra  extract,  Ilex purpurea  Hassk extract,  Innula racemosa  extract,  Ligusticum chiangxiong  extract,  Ligusticum lucidum  extract,  Mallotus philippinensis  extract,  Mimusops elengi  extract,  Portulaca oleracea  extract,  Portulaca sativa  extract,  Atriplex portulacoides  extract,  Morinda citrifolia  extract,  Moringa oleifera  extract,  Naringi crenulata  extract,  Nerium indicum  extract,  Psoralea corylifolia  extract,  Stenoloma chusana  extract,  Terminalia bellerica  extract, tomato glycolipid,  Amorphophallus campanulatus  extract,  Olisma orientale  extract,  Plumbago indica, Cananga odorata  extract,  Sapindus rarak  extract,  Curcuma xanthorrhiza  extract,  Physalis minima  extract,  Stephania rotunda  extract,  Rhinacanthus nasutus  extract,  Humulus scandens  extract,  Sesbania grandiflora  extract,  Pouzolzia pentanda  extract,  Piper betel  extract,  Jasminum sambac  extract;  Eliptica prostrata  Linn. extract;  Clitoria ternatea  Linn. extract;  Ozothamnus obcordatus  extract;  Erythrina flabelliformis  extract;  Lonchocarpus capassa  extract;  Sophora tomentosa  extract; Tetrandrine; Carvacrol;  Retinyl punicate ; MycoFusions Coriolus Black Corn Biomass; MycoFusions Maitake Waxy Hulless Barley Biomass;  Zanthoxylum nitidium  extract;  Ophiopogon Thunb . P.E. extract;  Radix platycodonis  extract; and  Cocculus glaucescens  extract paxillin;  Coccinia grandis  extract;  Trifolium hybridum  extract;  Eremophila mitchellii  extract;  Kunzea ambigua  extract; Tanshinone HA; Tetrandrine; Carvacrol; cis-6-Nonenol;  Retinyl punicate; Retinyl oleate ; Equol;  Terminalia belerica  extract;  Stephania solid  extract; and  Rosemary  extract, L-4-thiazolylalanine, tetramethylpyrazine, (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid, 3-hydroxy-4,5-dimethylfuran-2(5H)-one, black cohosh ( Cimicifuga racemosa, Capsicum amuum , cedar, Derris Scandens Benth,  Erythrina flabelliformis, Withania somniferia , fir needle ( Abies alba ),  Helichrysum gymnocephalum , holly ( Ilex ), laurel clock vine ( Thunbergia laurifloria ),  Leptospermum lanigerum, Grifola frondosa, Melicope hayesii , norway spruce,  Phyllarthron bojeranum , pine needles,  Piper nigrum, Sophora tomentosa , spruce needles,  Thuja,  1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine or a cosmetically acceptable salt thereof; desthiobiotin; a pyridone-fused azabicyclic compound of the formula 
       
         
           
           
               
               
           
         
       
       a pyridone-fused azabicyclic compound of the formula 
       
         
           
           
               
               
           
         
       
       and compatible combinations thereof. 
     
     
         18 . The composition of  claim 1  further comprising at least one skin active agent selected from the group consisting of  Abies pindrow  extract,  Acacia catechu  extract,  Anogeissus latifolia  extract,  Asmunda japonica  extract,  Azadirachta indica  extract,  Butea frondosa  extract,  Cedrus deodara  extract,  Emblica officinalis  extract,  Ficus benghalensis  extract,  Glycyrrhiza glabra  extract,  Ilex purpurea  Hassk extract,  Innula racemosa  extract,  Ligusticum chiangxiong  extract,  Ligusticum lucidum  extract,  Mallotus philippinensis  extract,  Mimusops elengi  extract,  Portulaca oleracea  extract,  Portulaca sativa  extract,  Atriplex portulacoides  extract,  Morinda citrifolia  extract,  Moringa oleifera  extract,  Naringi crenulata  extract,  Nerium indicum  extract,  Psoralea corylifolia  extract,  Stenoloma chusana  extract,  Terminalia bellerica  extract, tomato glycolipid,  Amorphophallus campanulatus  extract,  Olisma orientale  extract,  Plumbago indica, Cananga odorata  extract,  Sapindus rarak  extract,  Curcuma xanthorrhiza  extract,  Physalis minima  extract,  Stephania rotunda  extract,  Rhinacanthus nasutus  extract,  Humulus scandens  extract,  Sesbania grandiflora  extract,  Pouzolzia pentanda  extract,  Piper betel  extract,  Jasminum sambac  extract;  Eliptica prostrata  Linn. extract;  Clitoria ternatea  Linn. extract;  Ozothamnus obcordatus  extract;  Erythrina flabelliformis  extract;  Lonchocarpus capassa  extract;  Sophora tomentosa  extract; Tetrandrine; Carvacrol;  Retinyl punicate ; MycoFusions Coriolus Black Corn Biomass; MycoFusions Maitake Waxy Hulless Barley Biomass;  Zanthoxylum nitidium  extract;  Ophiopogon Thunb . P.E. extract;  Radix platycodonis  extract; and  Cocculus glaucescens  extract paxillin;  Coccinia grandis  extract;  Trifolium hybridum  extract;  Eremophila mitchellii  extract;  Kunzea ambigua  extract; Tanshinone HA; Tetrandrine; Carvacrol; cis-6-Nonenol;  Retinyl punicate; Retinyl oleate ; Equol;  Terminalia belerica  extract;  Stephania solid  extract; and  Rosemary  extract, L-4-thiazolylalanine, tetramethylpyrazine, (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid, 3-hydroxy-4,5-dimethylfuran-2(5H)-one, black cohosh ( Cimicifuga racemosa, Capsicum amuum , cedar, Derris Scandens Benth,  Erythrina flabelliformis, Withania somniferia , fir needle ( Abies alba ),  Helichrysum gymnocephalum , holly ( Ilex ), laurel clock vine ( Thunbergia laurifloria ),  Leptospermum lanigerum, Grifola frondosa, Melicope hayesii , norway spruce,  Phyllarthron bojeranum , pine needles,  Piper nigrum, Sophora tomentosa , spruce needles,  Thuja,  1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine or a cosmetically acceptable salt thereof; desthiobiotin; a pyridone-fused azabicyclic compound of the formula 
       
         
           
           
               
               
           
         
       
       a pyridone-fused azabicyclic compound of the formula 
       
         
           
           
               
               
           
         
       
       and compatible combinations thereof. 
     
     
         19 . The composition of  claim 1 , wherein hydrogen peroxide is not present in the composition. 
     
     
         20 . The composition of  claim 1 , wherein tarrow root is not present in the composition.