Organic Compounds

Abstract

The present invention relates to salts, polymorphs and hydrates of 2-Amino-2-[2-(4-C 2-20 -alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.

1 . A salt of 2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol (FTY720), wherein the salt is selected from tartrate, lactate, benzoate, succinate, malonate, acetate and propionate salts, the salt being optionally crystalline. 
     
     
         2 . A salt according to  claim 1 , wherein the salt is selected from tartrate, lactate, succinate and malonate salts, the salt being optionally crystalline. 
     
     
         3 . A salt according to  claim 1 , which is in substantially pure crystalline form. 
     
     
         4 . A salt of  claim 1 , for use in therapy. 
     
     
         5 . A salt of  claim 1 , for use in the treatment or prevention of organ or tissue transplant rejection, autoimmune diseases or inflammatory conditions. 
     
     
         6 . A pharmaceutical composition comprising a salt of  claim 1  together with a pharmaceutically acceptable carrier or excipient. 
     
     
         7 . A method for the treatment or prevention of organ or tissue transplant rejection, autoimmune diseases or inflammatory conditions in a patient, which comprises administering a therapeutically effective amount of a salt of  claim 1 .