Enhancing coagulation or reducing fibrinolysis

Abstract

Methods for controlling bleeding (e.g., enhancing coagulation and reducing fibrinolysis) in a subject are disclosed. The methods include selecting a subject in need of enhanced coagulation or reduced fibrinolysis, and administering to the subject a carbon monoxide releasing molecule (CORM). Examples of CORMs include tricarbonyldichlororuthenium (II) dimer, tricarbonylchloro-(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. Further disclosed are compositions and methods for treating a subject in need of a blood product by administering to the subject a composition including a CORM and a blood product (e.g., cryoprecipitate or fresh frozen plasma).

1 - 29 . (canceled) 
     
     
         30 . A composition, comprising a CORM and a blood product. 
     
     
         31 . The composition of  claim 30 , wherein the blood product is selected from cryoprecipitate or fresh frozen plasma. 
     
     
         32 . The composition of  claim 30 , wherein the CORM is tricarbonyldichlororuthenium (II) dimer. 
     
     
         33 . The composition of  claim 30 , wherein the CORM is selected from the group consisting of tricarbonylchloro(glycinato)ruthenium (II), sodium boranocarbonate, dimanganese decacarbonyl, and iron pentacarbonyl. 
     
     
         34 . A method of treating a subject in need of a blood product, comprising administering to the subject the composition of  claim 30 .