External patches containing etofenamate

Abstract

The present invention provides to patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation. In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50% by weight of synthetic rubber polymer, 10-60% by weight of adhesive resin and 25-60% by weight of liquid paraffin, and the drug is etofenamate. According to the present invention, there is obtainable the patches having excellent skin-permeability and therapeutic effect by the drug with lower irritation.

1 . In an external patch in which an adhesive layer containing an adhesive base and a drug are laminated with a backing, the external patch wherein the adhesive base contains 5-50% by weight of synthetic rubber, 10-60% by weight of adhesive resin and 25-60% by weight of liquid paraffin, and the drug is etofenamate. 
     
     
         2 . The external patch according to  claim 1  wherein the synthetic rubber is styrene-isoprene-styrene block copolymer. 
     
     
         3 . The external patch according to  claim 1  wherein the adhesive resin is an alicyclic saturated hydrocarbon resin. 
     
     
         4 . The external patch according to  claim 1  wherein the adhesive layer further contains a plasticizer. 
     
     
         5 . The external patch according to  claim 4 , wherein the plasticizer is crotamiton or isopropyl myristate. 
     
     
         6 . The external patch according to  claim 2  wherein the adhesive layer further contains a plasticizer. 
     
     
         7 . The external patch according to  claim 3  wherein the adhesive layer further contains a plasticizer. 
     
     
         8 . The external patch according to  claim 6 , wherein the plasticizer is crotamiton or isopropyl myristate. 
     
     
         9 . The external patch according to  claim 7 , wherein the plasticizer is crotamiton or isopropyl myristate.