Formulations for the oral administration of therapeutic agents and related methods

Abstract

Formulations for the oral administration of therapeutic agents, methods for administering therapeutic agents using the formulations, and methods for treating conditions and diseases using the formulations.

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 
     
         1 . An amphotericin B formulation, comprising,
 (a) amphotericin B;   (b) one or more fatty acid glycerol esters; and   (c) one or more polyethylene oxide-containing phospholipids or one or more polyethylene oxide-containing fatty acid esters.   
     
     
         2 . A method for administering amphotericin B, comprising administering a formulation of  claim 1  to a subject in need thereof. 
     
     
         3 . A method for treating an infectious disease treatable by the administration of amphotericin B, comprising administering to a subject in need thereof a therapeutically effective amount of an amphotericin B formulation of  claim 1 . 
     
     
         4 . A formulation for the delivery of a therapeutic agent, comprising,
 (a) a therapeutic agent;   (b) one or more fatty acid glycerol esters; and   (c) one or more polyethylene oxide-containing phospholipids or one or more polyethylene oxide-containing fatty acid esters.   
     
     
         5 . A method for administering a therapeutic agent, comprising administering a formulation of  claim 4  to a subject in need of such agent. 
     
     
         6 . A composition for formulating a therapeutic agent, comprising,
 (a) one or more fatty acid glycerol esters; and   (b) one or more polyethylene oxide-containing phospholipids or one or more polyethylene oxide-containing fatty acid esters.   
     
     
         7 . A method for formulating a therapeutic agent, comprising combining a therapeutic agent with a composition of  claim 6 .