US2014221351A1PendingUtilityA1
Novel 1,2- bis-sulfonamide derivatives as chemokine receptor modulators

Assignee: ALLERGAN INCPriority: Dec 16, 2010Filed: Apr 8, 2014Published: Aug 7, 2014
Est. expiryDec 16, 2030(~4.4 yrs left)· nominal 20-yr term from priority
Inventors:Haiqing Yuan Richard L. Beard Xiaoxia Liu John E. Donello Veena Viswanath Michael E. Garst
A61P 43/00A61P 37/08A61P 27/14A61P 27/02A61P 27/00A61P 29/00A61K 31/343C07D 333/34A61K 31/428C07D 407/12C07D 413/12A61K 31/4725C07D 417/12A61K 31/635A61K 31/422C07C 311/44A61K 31/55A61K 31/381C07D 513/04A61K 31/498A61K 31/5383C07D 231/18C07D 498/04C07D 413/14A61K 31/4155A61K 31/4196C07D 405/12C07D 409/12A61K 31/429A61K 31/37C07D 409/14A61K 31/423C07C 311/21A61K 31/497C07D 307/82A61K 31/4709A61K 31/5377A61K 31/506A61K 31/427A61K 31/4436A61K 31/404A61K 31/4245A61K 31/538A61K 31/18A61P 17/00
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Claims
Abstract

The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A compound having Formula I, its enantiomers, diastereoisomers, tautomers or a pharmaceutically acceptable salt thereof, 
       
         
           
           
               
               
           
         
         wherein: 
         R 1  is H or substituted or unsubstituted C 1-6  alkyl; 
         R 2  is H or substituted or unsubstituted C 1-6  alkyl; 
         R 3  is N or C—R 7 ; 
         R 4  is N or C—R 8 ; 
         R 5  is substituted or unsubstituted C 1-6  alkyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C 3-8  cycloalkyl, substituted or unsubstituted C 3-8  cycloalkenyl or is substituted or unsubstituted C 6-10  aryl; 
         R 6  is 2-thienyl; 
         R 15  is N or C—R 16 ; 
         R 17  is N or C—R 18 ; 
         R 7  is H, substituted or unsubstituted C 1-6  alkyl or halogen; 
         R 8  is H, substituted or unsubstituted C 1-6  alkyl or halogen; 
         R 16  is H, substituted or unsubstituted C 1-6  alkyl or halogen; 
         R 18  is H, substituted or unsubstituted C 1-6  alkyl or halogen; 
         and with the proviso: 
         R 5  is not 
       
       
         
           
           
               
               
           
         
       
       or 2-benzofuran. 
     
     
         2 . A compound according to  claim 1 , wherein:
 R 1  is H; and   R 2  is H.   
     
     
         3 . A compound according to  claim 1 , wherein:
 R 5  is selected from: 1-methyl-1H-imidazole, 3-pyridine, 1,3-dimethyl-1H-pyrazole, 1-methyl-1H-pyrazole, 1-methyl-1H-imidazole, 1-methyl-1H-indole, 2-oxoindoline, 1-methyl-2,3-dioxoindoline, 1-methyl-2-oxoindoline, 2-furan, -3,5-dimethylisoxazole, 5-isoxazol-3-ylthiophene, 2-oxo-2,3-dihydro-1,3-benzoxazole, 1,3-benzothiazole, 1H-1,2,4-triazole, 2-chloro-1,3-benzothiazole, 2,5-dichloro-3-thienyl, 1H-pyrazole, thiophene-2-carboxylate, 2-chloro-quinoline, 2,3-dihydro-1H-inden1,3-benzodioxole, quinoline, 2,4-dimethyl-1,3-thiazole, 4-methyl-1,3-thiazol-2-yl}acetamide, 5-chloro-8-quinoline, 3,5-dimethyl-1H-pyrazole, 1-(phenylsulfonyl)-1H-pyrrole, N-acetylindoline, 2-oxo-2H-chromene, 6-phenoxypyridine, 2,5-dimethyl-3-thienyl, 5-methyl-1-benzothiophene, 2,5-dimethylfuran, methyl-2-methyl-3-furoate, 3-oxo-3,4-dihydro-2H-1,4-benzoxazine, 2-imidazo[2,1-b][1,3]thiazole, 6-morpholin-4-ylpyridine, 5-pyridin-2-ylthiophene, 4-dihydro-2H-pyrido[3,2-b][1,4]oxazine, 3-methyl-8-quinoline, 5-isoxazol-5-ylthiophene, 5,2-chloro-thienyl, 2,2-dimethylchromane, 2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine, 4-methyl-3,4-dihydro-2H-1,4-benzoxazine, 4-acetyl-3,4-dihydro-2H-1,4-benzoxazine, 2,4-dimethyl-1,3-thiazole, 3,5-dimethylisoxazole, 5-chloro-3-methyl-1-benzothien-2-yl, 4-methyl-1,3-thiazol-2-yl}acetamide, 1H-1,2,4-triazole, 5-chlorothiophene-2-carboxylate, 2-oxoindoline, 2-oxo-2,3-dihydro-1,3-benzoxazole, 5-isoxazol-3-yl-2-thienyl, 2-chloroquinoline, 2,5-dichloro-3-thienyl, 6-morpholin-4-ylpyridine, 4-methoxythiophene, 3-furyl, 1-methyl-1H-pyrazole, 6-chloroimidazo[2,1-b][1,3]thiazole, 1-acetyl-indoline, isonicotinate, 4-methyl-3,4-dihydro-2H-1,4-benzoxazine, 3,4-dihydro-2H-1,5-benzodioxepine, 2,2-dimethylchromane, 5-pyridin-2-yl-2-thienyl, 4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine, 3-oxo-3,4-dihydro-2H-1,4-benzoxazine, 5,6-dichloro-3-pyridine, 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline and 4-acetyl-3,4-dihydro-2H-1,4-benzoxazine.   
     
     
         4 . A compound according to  claim 1 , wherein:
 R 7  is H or halogen; and   R 8  is H or halogen.   
     
     
         5 . A compound according to  claim 1 , wherein:
 R 7  is halogen; and   R 8  is H.   
     
     
         6 . A compound according to  claim 1 , wherein:
 R 7  is H; and   R 8  is halogen.   
     
     
         7 . A compound according to  claim 1 , wherein:
 R 7  is halogen; and   R 8  is halogen.   
     
     
         8 . A compound according to  claim 1 , wherein:
 R 16  is H or halogen; and   R 18  is H or halogen.   
     
     
         9 . A compound according to  claim 1 , wherein:
 R 16  is H; and   R 18  is H.   
     
     
         10 . A compound according to  claim 1 , selected from:
 N-(4,5-dichloro-2-{[(3-chloro-4-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(isobutylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3,5-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,4-dimethyl-1,3-thiazole-5-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,5-dimethylisoxazole-4-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxoindoline-5-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide;   4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid;   5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methoxybenzoic acid;   N-(4,5-dichloro-2-{[(2,4-dimethoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[2-(methylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   Methyl 4-[({4,5-dichloro-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoate;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2H-chromene-6-sulfonamide;   6-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}imidazo[2,1-b][1,3]thiazole-5-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,5-dimethylfuran-3-sulfonamide;   N-[4,5-dichloro-2-({[4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-pyrazole-3-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-indole-4-sulfonamide;   N-(4,5-dichloro-2-{[(2,5-dimethyl-3-thienyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide;   N-{(4,5-dichloro-2-[(3,5-dichloro-4-hydroxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,2-dimethyl-1H-imidazole-4-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3-methylquinoline-8-sulfonamide;   N-{5-chloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzofuran-2-sulfonamide;   N-[3-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)pyridin-2-yl]thiophene-2-sulfonamide;   N-[5-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)pyridin-2-yl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}furan-2-sulfonamide;   N-{2-[(biphenyl-4-ylsulfonyl)amino]-4,5-dichlorophenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3,5-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3,5-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,5-dimethylisoxazole-4-sulfonamide;   N-(4,5-dichloro-2-{[(4-chloro-2,5-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(2-methylphenoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-isoxazol-3-ylthiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2,4-dimethylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2,6-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(methylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3,4-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   5-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3-methyl-1-benzothiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4-chloro-3-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide;   4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid;   5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methoxybenzoic acid;   N-(4,5-dichloro-2-{[(3-chloro-4-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-cyanophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   2-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,3-benzothiazole-6-sulfonamide;   N-(4,5-dichloro-2-{[(3,4-dimethylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[3-(methylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   3-{4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]phenyl}propanoic acid;   5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-ethoxybenzoic acid;   N-{4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methylphenyl}acetamide;   N-[2-({[3,5-bis(trifluoromethyl)phenyl]sulfonyl}amino)-4,5-dichlorophenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1H-pyrazole-4-sulfonamide;   N-(4,5-dichloro-2-{[(3-chlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-[2-({[4-(benzyloxy)phenyl]sulfonyl}amino)-4,5-dichlorophenyl]thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   2-chloro-5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-fluorobenzoic acid;   methyl 5-chloro-3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]thiophene-2-carboxylate;   3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-fluorobenzoic acid;   2-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-6-sulfonamide;   N-(4,5-dichloro-2-{[(5-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2,3-dihydro-1H-inden-5-ylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4-chlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(1-naphthylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,3-benzodioxole-5-sulfonamide;   N-[4,5-dichloro-2-({[2-(trifluoromethoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzofuran-5-sulfonamide;   N-(4,5-dichloro-2-{[(2,6-dimethylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-3-sulfonamide;   N-(4,5-dichloro-2-{[(2,3-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   methyl 4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoate;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-8-sulfonamide;   N-(4,5-dichloro-2-{[(2-chlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,4-dimethyl-1,3-thiazole-5-sulfonamide;   N-(4,5-dichloro-2-{[(3-chloro-4-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methyl-1,3-thiazol-2-yl}acetamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}isoquinoline-5-sulfonamide;   5-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-8-sulfonamide;   N-(4,5-dichloro-2-{[(2,5-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2,4,5-trifluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3,4-dimethoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2-methoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[3-(difluoromethoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   methyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]thiophene-2-carboxylate;   N-(4,5-dichloro-2-{[(2,5-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,5-dimethyl-1H-pyrazole-4-sulfonamide;   N-(4,5-dichloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-6-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-(phenylsulfonyl)-1H-pyrrole-3-sulfonamide;   N-(4,5-dichloro-2-{[(3,5-dimethylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4-methoxy-3-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-chloro-4-methoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[3-(1-methyl-1H-pyrazol-3-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-4-methyl-2-phenyl-1,3-thiazole-5-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzofuran-2-sulfonamide;   5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methylbenzoic acid;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2H-chromene-6-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-6-phenylpyridine-3-sulfonamide;   ethyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]isonicotinate;   N-[4,5-dichloro-2-({[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,3-dihydro-1-benzofuran-5-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-6-phenoxypyridine-3-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-phenylthiophene-2-sulfonamide;   3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methylbenzoic acid;   N-(4,5-dichloro-2-{[(2,5-dimethyl-3-thienyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{2-chloro-4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]phenyl}acetamide;   N-(4,5-dichloro-2-{[(5-chloro-2,4-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(1-methyl-1H-pyrazol-3-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-methyl-1-benzothiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,5-dimethylfuran-3-sulfonamide;   N-[4,5-dichloro-2-({[4-(pyrrolidin-1-ylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methyl-3-furoate;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonamide;   2,4-dichloro-5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid;   N-[4,5-dichloro-2-({[4-(difluoromethoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(5-{[(dimethylamino)carbonyl]amino}-2-ethoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methoxyphenyl}acetamide;   6-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}imidazo[2,1-b][1,3]thiazole-5-sulfonamide;   N-[4,5-dichloro-2-({[3-(1-methyl-1H-pyrazol-5-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-1-methyl-1H-pyrrole-2-carboxylate;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-methylfuran-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(phenoxymethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4-phenoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   5,6-dichloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide;   N-(4,5-dichloro-2-{[(2-fluoro-4-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2-ethoxy-5-{[(methylamino)carbonyl]amino}phenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-6-morpholin-4-ylpyridine-3-sulfonamide;   N-{4,5-dichloro-2-[({3-[(6-methylpyrazin-2-yl)oxy]phenyl}sulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}chromane-6-sulfonamide;   N-[4,5-dichloro-2-({[4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]sulfonyl}amino) phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-methylthiophene-2-sulfonamide;   5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-hydroxybenzoic acid;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzothiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2,4-dichloro-5-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-fluoro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   methyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoate;   methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methoxythiophene-3-carboxylate;   methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-furoate;   N-(4,5-dichloro-2-{[(2-chloro-4-cyanophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-pyrazole-3-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-indole-7-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-pyridin-2-ylthiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4′-fluorobiphenyl-4-yl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-fluoro-4-methoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2,3-dihydro-1,3-benzothiazole-6-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}furan-3-sulfonamide;   N-[4,5-dichloro-2-({[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   ethyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-3-furoate;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,3-dihydro-1-benzofuran-7-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-methyl-1,3-benzothiazole-6-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide;   N-(4,5-dichloro-2-{[(4-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-cyano-4-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-1,3-thiazol-2-yl}acetamide;   N-{4,5-dichloro-2-[({4-[(6-methylpyrazin-2-yl)oxy]phenyl}sulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-pyrimidin-2-ylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   methyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methoxybenzoate;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzothiophene-3-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-sulfonamide;   5-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,3-dimethyl-1H-pyrazole-4-sulfonamide;   N-{4,5-dichloro-2-[(3-thienylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(5-chloro-2-naphthyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{2-[(biphenyl-3-ylsulfonyl)amino]-4,5-dichlorophenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2-fluoro-5-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   4-chloro-3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid;   3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methoxybenzoic acid;   N-[4,5-dichloro-2-({[4-(pyridin-2-yloxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-naphthylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid;   N-[4,5-dichloro-2-({[6-(dimethylamino)-2-naphthyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide;   N-(4,5-dichloro-2-{[(4′-chlorobiphenyl-4-yl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(2-{[(3-acetylphenyl)sulfonyl]amino}-4,5-dichlorophenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide;   N-{4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzyl}acetamide;   N-[4,5-dichloro-2-({[3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[2-(methylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3-methylquinoline-8-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,3-dihydro-1,4-benzodioxine-6-sulfonamide;   N-[4,5-dichloro-2-({[3-(2-methylpyrimidin-4-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-Sulfonamide;   6-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-6-methoxypyridine-3-sulfonamide;   methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methylbenzoate;   N-(4,5-dichloro-2-{[(2,5-dimethoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(2-{[(4-acetylphenyl)sulfonyl]amino}-4,5-dichlorophenyl)thiophene-2-sulfonamide;   methyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methylbenzoate;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-isoxazol-5-ylthiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-(1,3-oxazol-5-yl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(5-chloro-2-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   methyl 2-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methoxybenzoate;   5-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4-pyrimidin-2-ylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(methylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3,5-dichloro-4-hydroxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   2-chloro-5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid;   N-[4,5-dichloro-2-({[4-(pyridin-3-yloxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-imidazole-4-sulfonamide;   N-{4,5-dichloro-2-[(ethylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4-chloro-2-fluoro-5-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-fluorobenzoic acid;   N-{2-[(biphenyl-2-ylsulfonyl)amino]-4,5-dichlorophenyl}thiophene-2-sulfonamide;   N-{3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methylphenyl}acetamide;   N-(2-{[(5-tert-butyl-2-methylphenyl)sulfonyl]amino}-4,5-dichlorophenyl)thiophene-2-sulfonamide;   N-{2-[(benzylsulfonyl)amino]-4,5-dichlorophenyl}thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(isobutylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,2-dimethylchromane-6-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,2-dimethyl-1H-imidazole-4-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-7-sulfonamide;   N-(4,5-dichloro-2-{[(4-cyclohexylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   4-chloro-N-1-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}benzene-1,3-disulfonamide;   N-(4,5-dichloro-2-{[(4-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]phenyl}acetamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-indole-4-sulfonamide;   N-(2-{[(4-bromo-3-methylphenyl)sulfonyl]amino}-4,5-dichlorophenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(3-chloro-4-cyanophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-{4,5-dichloro-2-[(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)amino]phenyl}thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(2-chlorophenoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(4-methoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-(4,5-dichloro-2-{[(2-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   2-{4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]phenoxy}acetamide;   N-(4,5-dichloro-2-{[(2,4-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,5-dimethyl-1-phenyl-1H-pyrazole-4-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-4-methyl-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonamide;   2-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide;   4-acetyl-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonamide;   N-(4,5-dichloro-2-{[(2,6-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(1H-pyrazol-1-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   N-[4,5-dichloro-2-({[4-(1,3-oxazol-5-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide;   methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-(methylamino)benzoate;   5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-(methylamino)benzoic acid;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-indole-5-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxoindoline-5-sulfonamide;   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-2,3-dioxoindoline-5-sulfonamide; and   N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-2-oxoindoline-5-sulfonamide.   
     
     
         11 . A pharmaceutical composition comprising as active ingredient a therapeutically effective amount of a compound according to  claim 1  and a pharmaceutically acceptable adjuvant, diluent or carrier. 
     
     
         12 . A pharmaceutical composition according to  claim 11  wherein the compound is selected from:
 N-(4,5-dichloro-2-{[(3-chloro-4-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(isobutylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,5-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,4-dimethyl-1,3-thiazole-5-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,5-dimethylisoxazole-4-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxoindoline-5-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide; 
 4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid; 
 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methoxybenzoic acid; 
 N-(4,5-dichloro-2-{[(2,4-dimethoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[2-(methylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 Methyl 4-[({4,5-dichloro-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoate; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2H-chromene-6-sulfonamide; 
 6-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}imidazo[2,1-b][1,3]thiazole-5-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,5-dimethylfuran-3-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-pyrazole-3-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-indole-4-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,5-dimethyl-3-thienyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide; 
 N-{(4,5-dichloro-2-[(3,5-dichloro-4-hydroxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,2-dimethyl-1H-imidazole-4-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3-methylquinoline-8-sulfonamide; 
 N-{5-chloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzofuran-2-sulfonamide; 
 N-[3-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)pyridin-2-yl]thiophene-2-sulfonamide; 
 N-[5-chloro-3-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)pyridin-2-yl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}furan-2-sulfonamide; 
 N-{2-[(biphenyl-4-ylsulfonyl)amino]-4,5-dichlorophenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,5-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,5-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,5-dimethylisoxazole-4-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-chloro-2,5-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(2-methylphenoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-isoxazol-3-ylthiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,4-dimethylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,6-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(methylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,4-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 5-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3-methyl-1-benzothiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-chloro-3-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide; 
 4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid; 
 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methoxybenzoic acid; 
 N-(4,5-dichloro-2-{[(3-chloro-4-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-cyanophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 2-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,3-benzothiazole-6-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,4-dimethylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[3-(methylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 3-{4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]phenyl}propanoic acid; 
 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-ethoxybenzoic acid; 
 N-{4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methylphenyl}acetamide; 
 N-[2-({[3,5-bis(trifluoromethyl)phenyl]sulfonyl}amino)-4,5-dichlorophenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1H-pyrazole-4-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-chlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-[2-({[4-(benzyloxy)phenyl]sulfonyl}amino)-4,5-dichlorophenyl]thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 2-chloro-5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-fluorobenzoic acid; 
 methyl 5-chloro-3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]thiophene-2-carboxylate; 
 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-fluorobenzoic acid; 
 2-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-6-sulfonamide; 
 N-(4,5-dichloro-2-{[(5-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2,3-dihydro-1H-inden-5-ylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-chlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(1-naphthylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,3-benzodioxole-5-sulfonamide; 
 N-[4,5-dichloro-2-({[2-(trifluoromethoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzofuran-5-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,6-dimethylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-3-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,3-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 methyl 4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoate; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-8-sulfonamide; 
 N-(4,5-dichloro-2-{[(2-chlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,4-dimethyl-1,3-thiazole-5-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-chloro-4-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methyl-1,3-thiazol-2-yl}acetamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}isoquinoline-5-sulfonamide; 
 5-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-8-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,5-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,4,5-trifluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,4-dimethoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2-methoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[3-(difluoromethoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 methyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]thiophene-2-carboxylate; 
 N-(4,5-dichloro-2-{[(2,5-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,5-dimethyl-1H-pyrazole-4-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}quinoline-6-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-(phenylsulfonyl)-1H-pyrrole-3-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,5-dimethylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-methoxy-3-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-chloro-4-methoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[3-(1-methyl-1H-pyrazol-3-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-4-methyl-2-phenyl-1,3-thiazole-5-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzofuran-2-sulfonamide; 
 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methylbenzoic acid; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2H-chromene-6-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-6-phenylpyridine-3-sulfonamide; 
 ethyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]isonicotinate; 
 N-[4,5-dichloro-2-({[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,3-dihydro-1-benzofuran-5-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-6-phenoxypyridine-3-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-phenylthiophene-2-sulfonamide; 
 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methylbenzoic acid; 
 N-(4,5-dichloro-2-{[(2,5-dimethyl-3-thienyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{2-chloro-4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]phenyl}acetamide; 
 N-(4,5-dichloro-2-{[(5-chloro-2,4-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(1-methyl-1H-pyrazol-3-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-methyl-1-benzothiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,5-dimethylfuran-3-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(pyrrolidin-1-ylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methyl-3-furoate; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonamide; 
 2,4-dichloro-5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid; 
 N-[4,5-dichloro-2-({[4-(difluoromethoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(5-{[(dimethylamino)carbonyl]amino}-2-ethoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methoxyphenyl}acetamide; 
 6-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}imidazo[2,1-b][1,3]thiazole-5-sulfonamide; 
 N-[4,5-dichloro-2-({[3-(1-methyl-1H-pyrazol-5-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-1-methyl-1H-pyrrole-2-carboxylate; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-methylfuran-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(phenoxymethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-phenoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 5,6-dichloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide; 
 N-(4,5-dichloro-2-{[(2-fluoro-4-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2-ethoxy-5-{[(methylamino)carbonyl]amino}phenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-6-morpholin-4-ylpyridine-3-sulfonamide; 
 N-{4,5-dichloro-2-[({3-[(6-methylpyrazin-2-yl)oxy]phenyl}sulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}chromane-6-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-methylthiophene-2-sulfonamide; 
 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-hydroxybenzoic acid; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzothiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,4-dichloro-5-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-fluoro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 methyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoate; 
 methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methoxythiophene-3-carboxylate; 
 methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-furoate; 
 N-(4,5-dichloro-2-{[(2-chloro-4-cyanophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-pyrazole-3-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-indole-7-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-pyridin-2-ylthiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4′-fluorobiphenyl-4-yl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-fluoro-4-methoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2,3-dihydro-1,3-benzothiazole-6-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}furan-3-sulfonamide; 
 N-[4,5-dichloro-2-({[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]sulfonyl}amino) phenyl]thiophene-2-sulfonamide; 
 ethyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-3-furoate; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,3-dihydro-1-benzofuran-7-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-methyl-1,3-benzothiazole-6-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,3,5-trimethyl-1H-pyrazole-4-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-cyano-4-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-1,3-thiazol-2-yl}acetamide; 
 N-{4,5-dichloro-2-[({4-[(6-methylpyrazin-2-yl)oxy]phenyl}sulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-pyrimidin-2-ylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 methyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methoxybenzoate; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-benzothiophene-3-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-4-methyl-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-7-sulfonamide; 
 5-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,3-dimethyl-1H-pyrazole-4-sulfonamide; 
 N-{4,5-dichloro-2-[(3-thienylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(5-chloro-2-naphthyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{2-[(biphenyl-3-ylsulfonyl)amino]-4,5-dichlorophenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2-fluoro-5-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 4-chloro-3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid; 
 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methoxybenzoic acid; 
 N-[4,5-dichloro-2-({[4-(pyridin-2-yloxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-naphthylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid; 
 N-[4,5-dichloro-2-({[6-(dimethylamino)-2-naphthyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide; 
 N-(4,5-dichloro-2-{[(4′-chlorobiphenyl-4-yl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(2-{[(3-acetylphenyl)sulfonyl]amino}-4,5-dichlorophenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonamide; 
 N-{4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzyl}acetamide; 
 N-[4,5-dichloro-2-({[3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[2-(methylsulfonyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3-methylquinoline-8-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,3-dihydro-1,4-benzodioxine-6-sulfonamide; 
 N-[4,5-dichloro-2-({[3-(2-methylpyrimidin-4-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-Sulfonamide; 
 6-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-6-methoxypyridine-3-sulfonamide; 
 methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methylbenzoate; 
 N-(4,5-dichloro-2-{[(2,5-dimethoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(2-{[(4-acetylphenyl)sulfonyl]amino}-4,5-dichlorophenyl)thiophene-2-sulfonamide; 
 methyl 3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-methylbenzoate; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-isoxazol-5-ylthiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-5-(1,3-oxazol-5-yl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(5-chloro-2-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[5-(dimethylamino)-1-naphthyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 methyl 2-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methoxybenzoate; 
 5-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-pyrimidin-2-ylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(methylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3,5-dichloro-4-hydroxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 2-chloro-5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]benzoic acid; 
 N-[4,5-dichloro-2-({[4-(pyridin-3-yloxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-imidazole-4-sulfonamide; 
 N-{4,5-dichloro-2-[(ethylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-chloro-2-fluoro-5-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-fluorobenzoic acid; 
 N-{2-[(biphenyl-2-ylsulfonyl)amino]-4,5-dichlorophenyl}thiophene-2-sulfonamide; 
 N-{3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-4-methylphenyl}acetamide; 
 N-(2-{[(5-tert-butyl-2-methylphenyl)sulfonyl]amino}-4,5-dichlorophenyl)thiophene-2-sulfonamide; 
 N-{2-[(benzylsulfonyl)amino]-4,5-dichlorophenyl}thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(isobutylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2,2-dimethylchromane-6-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1,2-dimethyl-1H-imidazole-4-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-7-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-cyclohexylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 4-chloro-N-1-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}benzene-1,3-disulfonamide; 
 N-(4,5-dichloro-2-{[(4-fluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{3-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]phenyl}acetamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-indole-4-sulfonamide; 
 N-(2-{[(4-bromo-3-methylphenyl)sulfonyl]amino}-4,5-dichlorophenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(3-chloro-4-cyanophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-{4,5-dichloro-2-[(5,6,7,8-tetrahydronaphthalen-2-ylsulfonyl)amino]phenyl}thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(2-chlorophenoxy)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(4-methoxyphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-(4,5-dichloro-2-{[(2-methylphenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 2-{4-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]phenoxy}acetamide; 
 N-(4,5-dichloro-2-{[(2,4-dichlorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,5-dimethyl-1-phenyl-1H-pyrazole-4-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-4-methyl-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonamide; 
 2-chloro-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}pyridine-3-sulfonamide; 
 4-acetyl-N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonamide; 
 N-(4,5-dichloro-2-{[(2,6-difluorophenyl)sulfonyl]amino}phenyl)thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(1H-pyrazol-1-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(2-methyl-1,3-thiazol-4-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 N-[4,5-dichloro-2-({[4-(1,3-oxazol-5-yl)phenyl]sulfonyl}amino)phenyl]thiophene-2-sulfonamide; 
 methyl 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-(methylamino)benzoate; 
 5-[({4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}amino)sulfonyl]-2-(methylamino)benzoic acid; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-1H-indole-5-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-2-oxoindoline-5-sulfonamide; 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-2,3-dioxoindoline-5-sulfonamide; and 
 N-{4,5-dichloro-2-[(2-thienylsulfonyl)amino]phenyl}-1-methyl-2-oxoindoline-5-sulfonamide.
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