Synthesis of epothilones, intermediates thereto and analogues thereof

Abstract

The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).

1 - 117 . (canceled) 
     
     
         118 . A compound having the formula: 
       
         
           
           
               
               
           
         
         wherein: 
         R 2  is a substituted or unsubstituted aryl, heteroaryl, arylalkyl, or heteroarylalkyl moiety; 
         R 5  and R 6  are each independently hydrogen or a protecting group; and 
         R B  is —CF 3 . 
       
     
     
         119 . The compound of  claim 118  wherein R 2  is a substituted or unsubstituted heteroaryl moiety. 
     
     
         120 . The compound of  claim 119 , wherein the heteroaryl moiety is substituted or unsubstituted isoxazolyl. 
     
     
         121 . The compound of  claim 120 , wherein R 5  and R 6  are each hydrogen. 
     
     
         122 . The compound according to  claim 120  or  121  wherein the heteroaryl moiety is substituted isoxazolyl. 
     
     
         123 . The compound according to  claim 120  or  121  wherein the heteroaryl moiety is unsubstituted isoxazolyl. 
     
     
         124 . The compound according to  claim 122  wherein the isoxazolyl is substituted with a —CH 2 OH group. 
     
     
         125 . A pharmaceutical composition comprising a compound according to any of  claims 118 - 121 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or diluent. 
     
     
         126 . A pharmaceutical composition comprising a compound according to  claim 122 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or diluent. 
     
     
         127 . A pharmaceutical composition comprising a compound according to  claim 123 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or diluent. 
     
     
         128 . A pharmaceutical composition comprising a compound according to  claim 124 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier or diluent.