US2014201856A1PendingUtilityA1
Animal models and therapeutic molecules
Est. expiryJul 8, 2029(~2.9 yrs left)· nominal 20-yr term from priority
C07K 16/18A01K 67/0275C07K 16/1239C07K 2317/92C07K 2317/565C07K 2317/51C07K 2317/21C07K 2317/14A01K 2217/072C12N 2015/8518C07K 2317/76C07K 2317/567C07K 2317/52C07K 2317/515C07K 16/1203A61K 2039/505A61K 39/35A61K 39/107A01K 2217/15A01K 2217/075A01K 67/0276A01K 67/0271C07K 16/462C07K 2317/24C12N 15/8509C07K 16/00A01K 2267/01A01K 2227/105A01K 2217/052A01K 2207/15C07K 2317/56A01K 2217/05A01K 67/0278A61P 37/02A01K 67/027C07K 16/461C12N 5/0606C12N 15/85
71
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
Claims
exact text as granted — not AI-modified1 . A host rodent whose genome comprises a chimeric immunoglobulin (Ig) locus, said chimeric Ig locus comprising human Tg locus DNA and host Ig locus DNA, said host Ig locus DNA comprising a host Ig upstream region and a host Ig downstream region, said host Ig upstream region comprising a host J region comprising a host J segment and said host Ig downstream region comprising a host Ig constant (C) region segment DNA comprising a host C segment, wherein said human Ig locus DNA is positioned downstream of said host Ig J region and upstream of said host Ig C region, said human Ig locus DNA comprising one 10 or more human Ig variable (V) segments and one or more human Ig joining (J) segments.
Join the waitlist — get patent alerts
Track US2014201856A1 — get alerts on status changes and closely related new filings.
We store only your email — no account needed. See our privacy policy.