C1orf59 peptides and vaccines including the same

Abstract

The present invention provides isolated peptides having the amino acid sequence of SEQ ID NO: 43 or immunologically active fragments thereof, which bind to HLA antigen and have cytotoxic T lymphocyte (CTL) inducibility. The present invention further provides peptides which include one, two, or several amino acid insertions, substitution or addition to the aforementioned peptides or fragments, but still have the cytotoxic T cell inducibility. Further provided are nucleic acids encoding any of these aforementioned peptides as well as pharmaceutical agents and compositions including any of the aforementioned peptides or nucleic acids. The peptides, nucleic acids, pharmaceutical agents and compositions of this invention may be used for treating cancer or tumor.

1 . An isolated peptide selected from the group consisting of:
 (a) SEQ ID NO: 26, 32, 34, 40 and 41; and   (b) SEQ ID NO: 26, 32, 34, 40 and 41 in which 1 or 2 amino acids are substituted as follows:   (i) the second amino acid from the N-terminus is selected from the group of phenylalanine, tyrosine, methionine and tryptophan; and/or   (ii) the C-terminal amino acid is selected from the group of phenylalanine, leucine, isoleucine, tryptophan and methionine.   
     
     
         2 . An isolated polynucleotide encoding a peptide of  claim 1 . 
     
     
         3 . An agent for inducing CTL, wherein the agent comprises one or more peptides of  claim 1  or one or more isolated polynucleotides encoding a peptide of  claim 1 . 
     
     
         4 . An agent comprising one or more peptides of  claim 1 , or one or more isolated polynucleotides encoding a peptide of  claim 1 . 
     
     
         5 . The agent of  claim 4 , which is formulated for the administration to a subject whose HLA antigen is HLA-A24. 
     
     
         6 . A method for inducing an antigen-presenting cell (APC) with CTL inducibility, wherein the method comprises one of the following steps:
 (a) contacting an APC with a peptide of  claim 1  in vitro, ex vivo or in vivo; and   (b) introducing a polynucleotide encoding a peptide of  claim 1  into an APC.   
     
     
         7 . The isolated peptide of  claim 1 , which has CTL inducibility. 
     
     
         8 . The isolated peptide of  claim 1 , which binds to an HLA antigen. 
     
     
         9 . The isolated peptide of  claim 8 , wherein the HLA antigen is HLA-A24.