Protein free formula

Abstract

The invention relates to the use of composition comprising free amino acids as a sole source of protein, a fatty acid source comprising long chain polyunsaturated fatty acids, a carbohydrate source comprising digestible and indigestible carbohydrates, and milk protein free Bifidobacteria for treating a person suffering from (a) colic, congestion, runny nose, wheezing, vomiting, diarrhoea, bloody stools, mucus in stools, rash, eczema, gastroesophageal reflux, eosinophilic esophagitis or asthma; (b) cow's milk allergy and/or food protein intolerance; and/or (c) infections, wherein the indigestible carbohydrate is selected from a milk protein free source and the total composition is essentially free of intact proteins.

1 . A composition comprising a protein component, a fat component, a digestible carbohydrate component, a non-digestible carbohydrate and Bifidobacteria wherein;
 (a) the protein component contains more than 99 wt. % free amino acids based on total protein, and comprising at least the following free amino acids: alanine, arginine, aspartic acid, cysteine, glycine, histidine, isoleucine, leucine, lysine, methionine, proline, serine, threonine, tryptophan, tyrosine, valine and glutamine;   (b) the digestible carbohydrate component contain less than 2 wt % lactose based on total digestible carbohydrate;   (c) the non-digestible carbohydrate comprises soluble fructan with an average DP between 2 to 200; and   (d) the fat component comprises between 0.1 wt % and 5 wt % LCPUFA based on total fatty acid content.   
     
     
         2 . A composition according to  claim 1  wherein the fat component comprises between 0.2 wt % and 1 wt % LCPUFA based on the total fatty acid content. 
     
     
         3 . A composition according to  claim 1 , further comprising a non-digestible, soluble galacturonic acid with an average DP between 2 and 200. 
     
     
         4 . A composition according to  claim 1 , comprising  Bifidobacterium breve.    
     
     
         5 . A composition according to  claim 1 , comprising arachidonic acid and/or docosahexaenoic acid. 
     
     
         6 . A composition according to  claim 1 , wherein the non-digestible carbohydrate consists of long chain FOS and short chain FOS. 
     
     
         7 . A composition according to  claim 6  wherein the long chain FOS has an average DP between 10-60 and the short chain FOS has an average DP between 3 and 10. 
     
     
         8 . A composition according to  claim 1  wherein the product is a powder or a liquid. 
     
     
         9 . A milk protein-free composition comprising:
 (a) a protein-free portion consisting of:
 (i) free amino acids as the sole source of amino acids in the protein-free portion, wherein the free amino acids comprise at least alanine, arginine, aspartic acid, cysteine, glycine, histidine, isoleucine, leucine, lysine, methionine, proline, serine, threonine, tryptophan, tyrosine, valine, and glutamine, 
 (ii) fatty acids comprising long-chain polyunsaturated fatty acids (LCPUFA), 
 (iii) digestible carbohydrates, and 
 (iv) indigestible carbohydrates obtained from a milk protein-free source; and 
   (b) Bifidobacteria obtained from a milk-protein-free culture;   
       wherein the milk protein-free composition is free of protein fragments of milk, and other than (b) is essentially free of intact proteins. 
     
     
         10 . A composition according to  claim 9  wherein the fat component comprises between 0.2 wt % and 1 wt % LCPUFA based on the total fatty acid content. 
     
     
         11 . A composition according to  claim 9 , further comprising indigestible, soluble fructan with an average DP between 2 to 200. 
     
     
         12 . A composition according to  claim 11 , further comprising an indigestible, soluble galacturonic acid with an average DP between 2 and 200. 
     
     
         13 . A composition according to  claim 9 , comprising  Bifidobacterium breve.    
     
     
         14 . A composition according to  claim 9 , comprising arachidonic acid and/or docosahexaenoic acid. 
     
     
         15 . A composition according to  claim 9 , wherein the indigestible carbohydrate consists of long chain FOS and short chain FOS. 
     
     
         16 . A composition according to  claim 15  wherein the long chain FOS has an average DP between 10-60 and the short chain FOS has an average DP between 3 and 10. 
     
     
         17 . A composition according to  claim 9  wherein the product is a powder or a liquid.