US2014187744A1PendingUtilityA1

Bilirubin Excretion Enhancer

48
Assignee: OTAGIRI MASAKIPriority: Aug 10, 2011Filed: Aug 9, 2012Published: Jul 3, 2014
Est. expiryAug 10, 2031(~5 yrs left)· nominal 20-yr term from priority
Inventors:Masaki OtagiriToru MaruyamaYu IshimaAi Minomo
A61K 38/385A61K 38/00C07K 14/765A61P 39/02
48
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Claims

Abstract

The purpose of the present invention is to establish a novel therapy method for hyperbilirubinemia and therefore, to provide a bilirubin excretion enhancer. The present invention provides a bilirubin excretion enhancer comprising, as an active ingredient, a serum albumin domain II-like protein comprising a serum albumin subdomain IIA. In one embodiment, the serum albumin subdomain IIA has an amino acid sequence of SEQ ID NO: 1. In one embodiment, the serum albumin domain II-like protein is a serum albumin domain II. In one embodiment, the serum albumin domain II comprises the amino add sequence of SEQ ID NO: 4.

Claims

exact text as granted — not AI-modified
1 . A bilirubin excretion enhancer comprising, as an active ingredient, a serum albumin domain II-like protein comprising a serum albumin subdomain IIA. 
     
     
         2 . The bilirubin excretion enhancer of  claim 1 , wherein the serum albumin subdomain IIA has an amino acid sequence of SEQ ID NO: 1. 
     
     
         3 . The bilirubin excretion enhancer of  claim 1 , wherein the serum albumin domain II-like protein is a serum albumin domain II. 
     
     
         4 . The bilirubin excretion enhancer of  claim 2 , wherein the serum albumin domain II-like protein is a serum albumin domain II. 
     
     
         5 . The bilirubin excretion enhancer of  claim 3 , wherein the serum albumin domain II has an amino acid sequence of SEQ ID NO: 4. 
     
     
         6 . The bilirubin excretion enhancer of  claim 4 , wherein the serum albumin domain II has an amino acid sequence of SEQ ID NO: 4. 
     
     
         7 . The bilirubin excretion enhancer of  claim 1 , wherein the serum albumin domain II-like protein comprises a serum albumin subdomain IB. 
     
     
         8 . The bilirubin excretion enhancer of  claim 1 , which is a urinary excretion enhancer. 
     
     
         9 . The bilirubin excretion enhancer of  claim 7 , which is a urinary excretion enhancer. 
     
     
         10 . The bilirubin excretion enhancer of  claim 1 , which is a 4Z, 15Z-bilirubin-IXα excretion enhancer. 
     
     
         11 . The bilirubin excretion enhancer of  claim 7 , which is a 4Z, 15Z-bilirubin-IXα excretion enhancer. 
     
     
         12 . The bilirubin excretion enhancer of  claim 8 , which is a 4Z, 15Z-bilirubin-IXα excretion enhancer. 
     
     
         13 . The bilirubin excretion enhancer of  claim 9 , which is a 4Z, 15Z-bilirubin-IXα excretion enhancer.

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