Spin Traps and Spin Labels for the Treatment of Rectal Hemorrhoids

Abstract

Nitrone, nitroso, and nitroxide spintraps and spin labels and their reduction products are claimed for the treatment of rectal hemorrhoids and rectal fissures.

What is claimed is: 
     
         1 . A method for the treatment of rectal hemorrhoids or rectal fissures with a spin trap or a spin label. 
     
     
         2 . A method comprising treatment of rectal hemorrhoids or rectal fissures where the spin label is TEMPO or a pharmacologically-active derivative including 4-hydroxy-TEMPO (TEMPOL), 4 aminotempol, (2,2,6,6-tetramethyl-1-piperidinyl-1-oxyl), (2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride monhydrte (Mito TEMPOL) and/or their reduced derivatives TEMPO-H, TEMPOL-H, or mito-TEMPOL-H, as well as their pharmacologically-active esters, amides and ethers. 
     
     
         3 . A method for the treatment of the above where the nitroxide, nitrone, or nitroso compound is phenylbutylnitrone, or its hydrolysis product, 2-methyl, 2-nitrosopropane. 
     
     
         4 . A method comprising treatment of rectal hemorrhoids and rectal fissures where the pharmacologically-effective dose is 0.01-1000 mg per day of a pharmacologically-active nitroxide spin-trap or spin label or their equivalent hydroxylamine or other reduced derivatives administered by suitable means such as orally, sublingually, transrectally, intramuscularly, intravenously, or subcutaneously.