Cross-Reactive Sensor Arrays And Methods of Use

Abstract

Disclosed herein are methods and compositions directed to the construction of aptamer-based receptors and cross-reactive sensor arrays of such receptors and the use of the same in disease detection and management.

What is claimed is: 
     
         1 . A cross-reactive sensor array composition comprising:
 (A) a first aptamer-based receptor capable of binding a first analyte; and   (B) a second aptamer-based receptor capable of binding a second analyte;   
       wherein binding of the first aptamer-based receptor to the first analyte is indicative of a disease state and binding of the second aptamer-based receptor to the second analyte is indicative of the absence of the disease state. 
     
     
         2 . A method of detection a disease state comprising contacting a sample to a cross-reactive sensor array composition comprising:
 (A) a first aptamer-based receptor capable of binding a first analyte if the first analyte is present in the sample; and   (B) a second aptamer-based receptor capable of binding a second analyte if the second analyte is present in the sample;   
       wherein binding of the first aptamer-based receptor to the first analyte is indicative of a disease state and binding of the second aptamer-based receptor to the second analyte is indicative of the absence of the disease state 
     
     
         3 . A method of detection a disease state comprising contacting a sample to a cross-reactive sensor array composition comprising:
 (A) a first collection of aptamer-based receptors capable of binding a first collection of analytes, if present, in the sample; and   (B) a second collection of aptamer-based receptors capable of binding a second collection of analytes, if present, in the sample;   
       wherein the binding pattern of individual receptors present in the first collection aptamer-based receptors of analytes of the first collection of analytes present in the sample are indicative of a disease state and wherein the binding pattern of individual receptors present in the second collection aptamer-based receptors of analytes of the second collection of analytes present in the sample are indicative of the absence of the disease state.