US2014186296A1PendingUtilityA1

Methods for Treatment of HIV and Other Infections Using a T-Cell or Viral Activator and Anti-Retroviral Combination Therapy

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Individually held — no corporate assignee on recordPriority: Nov 24, 1997Filed: Oct 4, 2013Published: Jul 3, 2014
Est. expiryNov 24, 2017(expired)· nominal 20-yr term from priority
Inventors:Johnson Wong
A61K 31/7072C12N 2501/505A61K 31/4412A61P 31/18A61K 38/191A61K 38/2013A61K 31/708A61K 38/2006C07K 2317/31A61K 39/395A61K 38/162C12N 2501/06C12N 2501/515A61K 2039/505C12N 2501/23A61K 38/168C07K 16/2815C07K 16/2809A61K 39/39541A61K 40/46A61K 40/11A61K 2239/31C12N 5/0636
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Claims

Abstract

Disclosed is a method for treating infection with a pathogen. The method involves administration of (1) a substance which induces active pathogen replication in a cell latently infected with HIV and (2) an anti-pathogen drug. Also disclosed are methods for expanding CD+ T cells from peripheral blood mononuclear cells isolated from human subjects in the presence of an antiretroviral drug and for treating HIV infection by infusing the expanded CD4+ cells into HIV-infected patients.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of treating a patient infected with HIV, comprising administering to said patient an amount of a T cell mitogen sufficient to induce activation of CD4+ T cells and replication of HIV with latently infected T cells and a therapeutically effective amount of an anti-retroviral drug. 
     
     
         2 .- 21 . (canceled)

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