Mouse model of retinal degeneration

Abstract

The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (AMD). The invention is also directed to non-human animals produced by the methods described herein. Methods of identifying an agent for use in inhibiting one or more pathological characteristics of retinal degeneration and/or AMD is also encompassed by the invention. Also provided is a method of treating AMD in an individual in need thereof comprising, administering to the individual an agent identified herein.

1 . A method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration comprising,
 a) administering a composition comprising an oxidatively modified protein to a non-human mammal; and   b) maintaining the non-human mammal under conditions in which one or more pathological characteristics of retinal degeneration develops in the non-human mammal,   thereby producing a non-human mammal having one or more pathological characteristics of retinal degeneration.   
     
     
         2 .- 24 . (canceled)