Biphenyl Acetate, Preparation and Uses Thereof

Abstract

A biphenyl acetate composition, which is a biphenyl acetic ammonia butantriol salt. The composition is prepared by reacting biphenyl acetic acid and ammonia butantriol in organic solvent, and a ratio of biphenyl acetic acid and ammonia butantriol is 1:1. The salt is capable of providing anti-inflammatory, analgesic, and antipyretic effect. The salt is unique and has stable chemical structure, can be prepared into an injection or a capsule, and has low toxicity and insignificant local and vascular irritating effect, thereby being prepared into a predetermined dosage in a controllable and precise manner.

What is claimed is: 
     
         1 . A composition for providing anti-inflammatory, analgesic, and antipyretic effect, wherein the composition is a biphenyl acetic ammonia butantriol salt having a chemical structure of: 
       
         
           
           
               
               
           
         
         wherein said biphenyl acetic ammonia butantriol salt has a molecular mass of 333.14. 
       
     
     
         2 . The composition according to  claim 1 , wherein said biphenyl acetic ammonia butantriol salt is soluble in methanol and methanamide, slightly soluble in water and ethanol, and insoluble in propanol and acetonitrile, wherein said biphenyl acetic ammonia butantriol salt has low toxicity to and low stimulative effect on a living object. 
     
     
         3 . The composition according to  claim 2 , wherein said biphenyl acetic ammonia butantriol salt is stable in structure and is non-allergic to the living object, thereby said biphenyl acetic ammonia butantriol salt is capable of being prepared into an injection form for administration by injection without causing allergy to the living object. 
     
     
         4 . The composition according to  claim 3 , is prepared by a method of preparation comprising the steps of: mixing biphenyl phenylacetic acid and ammonia butantriol in organic solvent to produce biphenyl acetic ammonia butantriol salt, wherein a ratio of the biphenyl phenylacetic acid and the ammonia butantriol is 1:1. 
     
     
         5 . The composition according to  claim 4 , wherein said biphenyl acetic ammonia butantriol salt produced by said method of preparation has a purity of more than 99.5% by weight. 
     
     
         6 . The composition according to  claim 4 , wherein said biphenyl phenylacetic acid is firstly dissolved in said organic solvent, and then said ammonia butantriol is added into said organic solvent for chemical reaction to generate said biphenyl acetic ammonia butantriol salt; wherein said organic solvent is selected from the group consisting of alcohol group and benzene group; wherein said alcohol group of said organic solvent is selected from the group consisting of methanol, anhydrous ethanol, acetone, and n-butanol; wherein said benzene group of said organic solvent is selected from the group consisting of benzyl and benzene; wherein a reaction temperature is set at 0-80° C. and a reaction time is set as 0.5-2 hours, 
     
     
         7 . The composition according to  claim 6 , wherein the method further comprises the steps of: purifying said biphenyl acetic ammonia butantriol salt such that a purity of said biphenyl acetic ammonia butantriol salt is greater than 99.5%. 
     
     
         8 . The composition according to  claim 1 , wherein said biphenyl acetic ammonia butantriol salt is prepared into an injection form adapted for injection to a living object, wherein said biphenyl acetic ammonia butantriol salt in said injection form is stable in structure and has insignificant local and vascular irritating effect such that said injection form is capable of providing anti-inflammatory, analgesic, and antipyretic effect by injecting into a living object, thereby said biphenyl acetic ammonia butantriol salt having a unique and stable chemical structure is capable of being prepared into a predetermined dosage in a controllable and precise manner. 
     
     
         9 . The composition according to  claim 8 , wherein said injection form is selected from the group consisting of injection liquid, injection cool powder and injection aseptic needle. 
     
     
         10 . The composition according to  claim 7 , wherein the method further comprises the steps of: preparing said biphenyl acetic ammonia butantriol salt into a capsule form adapted for oral administration, wherein said biphenyl acetic ammonia butantriol salt in said capsule form is stable in structure and has insignificant local and vascular irritating effect such that said biphenyl acetic ammonia butantriol salt is capable of providing anti-inflammatory, analgesic, and antipyretic effect to a living object, thereby said biphenyl acetic ammonia butantriol salt having a unique and stable chemical structure is capable of being prepared into a predetermined dosage in a controllable and precise manner. 
     
     
         11 . The composition according to  claim 7 , wherein said biphenyl acetic ammonia butantriol salt is obtained by evaporating a mixture of said biphenyl phenylacetic acid and said ammonia butantriol to obtain white powder after purification, and drying said white powder in a vacuum condition. 
     
     
         12 . The composition according to  claim 7 , wherein said biphenyl acetic ammonia butantriol salt is obtained by crystallizing a mixture of said biphenyl phenylacetic acid and said ammonia butantriol at a temperature below 0° C. to form a crystal of said mixture, and drying said crystal in a vacuum condition. 
     
     
         13 . A method of preparation of biphenyl acetic ammonia butantriol salt, comprising the steps of: mixing biphenyl phenylacetic acid with ammonia butantriol in organic solvent to generate biphenyl acetic ammonia butantriol salt, wherein biphenyl acetic ammonia butantriol salt having a chemical structure of: 
       
         
           
           
               
               
           
         
         wherein said biphenyl phenylacetic acid is firstly dissolved in said organic solvent, and then said ammonia butantriol is added into said organic solvent for chemical reaction to generate said biphenyl acetic ammonia butantriol salt; wherein a ratio of said biphenyl phenylacetic acid and said ammonia butantriol is 1:1; wherein said organic solvent is selected from the group consisting of alcohol group and benzene group; wherein said alcohol group of said organic solvent is selected from the group consisting of methanol, anhydrous ethanol, acetone, and n-butanol; wherein said benzene group of said organic solvent is selected from the group consisting of benzyl and benzene; wherein a reaction temperature is set at 0-80° C. and a reaction time is set as 0.5-2 hours, 
         wherein the method further comprises the steps of: purifying said biphenyl acetic ammonia butantriol salt such that a purity of said biphenyl acetic ammonia butantriol salt is greater than 99.5% and preparing said biphenyl acetic ammonia butantriol salt into an injection form adapted for injection to a living object, wherein said biphenyl acetic ammonia butantriol salt in said injection form is stable in structure and has insignificant local and vascular irritating effect such that said injection form is capable of providing anti-inflammatory, analgesic, and antipyretic effect by injecting into a living object, thereby said biphenyl acetic ammonia butantriol salt having a unique and stable chemical structure is capable of being prepared into a predetermined dosage in a controllable and precise manner. 
       
     
     
         14 . The method according to  claim 13 , wherein said injection form is selected from the group consisting of injection liquid, injection cool powder and injection aseptic needle. 
     
     
         15 . The method according to  claim 13 , further comprising the steps of: preparing said biphenyl acetic ammonia butantriol salt into a capsule form adapted for oral administration, wherein said biphenyl acetic ammonia butantriol salt in said capsule form is stable in structure and has insignificant local and vascular irritating effect such that said biphenyl acetic ammonia butantriol salt is capable of providing anti-inflammatory, analgesic, and antipyretic effect to a living object, thereby said biphenyl acetic ammonia butantriol salt having a unique and stable chemical structure is capable of being prepared into a predetermined dosage in a controllable and precise manner. 
     
     
         16 . The method according to  claim 13 , further comprising the steps of evaporating a mixture of said biphenyl phenylacetic acid and said ammonia butantriol to obtain white powder after purification, and drying said white powder in a vacuum condition to obtain said biphenyl acetic ammonia butantriol salt. 
     
     
         17 . The method according to  claim 14 , further comprising the steps of crystallizing a mixture of said biphenyl phenylacetic acid and said ammonia butantriol at a temperature below 0° C. to form a crystal of said mixture, and drying said crystal in a vacuum condition to obtain said biphenyl acetic ammonia butantriol salt.