US2014178985A1PendingUtilityA1
Beta 1,4-galactosyltransferases with altered donor and acceptor specificities, compositions and methods of use
Assignee: US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH & HUMAN SERVICPriority: Aug 22, 2007Filed: Jul 16, 2013Published: Jun 26, 2014
Est. expiryAug 22, 2027(~1.1 yrs left)· nominal 20-yr term from priority
C12N 9/1051A61K 38/00A61P 7/02A61P 37/04C12P 21/005
50
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Claims
Abstract
The invention relates generally to beta (1,4)-galactosyltransferase I mutants having altered donor and acceptor specificities, and methods of use thereof. In addition, the invention relates to methods for synthesizing oligosaccharides using the beta (1,4)-galactosyltransferase I mutants and to using the beta (1,4)-galactosyltransferase I mutants to conjugate agents, such as therapeutic agents or diagnostic agents, to acceptor molecules.
Claims
exact text as granted — not AI-modifiedWhat is claimed is:
1 - 16 . (canceled)
17 . A nucleic acid molecule comprising SEQ ID NO: 1.
18 . (canceled)
19 . An expression cassette or vector comprising the nucleic acid of claim 17 .
20 . (canceled)
21 . A host cell comprising the expression cassette or vector of claim 19 or 20 .
22 - 137 . (canceled)
138 . The nucleic acid molecule of claim 17 , wherein the nucleic acid molecule encodes a polypeptide fragment of a beta (1,4)-galactosyltransferase I that retains the ability to transfer GalNAc or galactose from a sugar donor to a sugar acceptor.
139 . The nucleic acid molecule of claim 17 , wherein the nucleic acid consists of SEQ ID NO: 1.Join the waitlist — get patent alerts
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