US2014178319A1PendingUtilityA1

Modulation Of Melanogenesis By Modification Of Tyrosinase By Palmitoylation

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Assignee: ELC MAN LLCPriority: Dec 20, 2012Filed: Dec 12, 2013Published: Jun 26, 2014
Est. expiryDec 20, 2032(~6.4 yrs left)· nominal 20-yr term from priority
Inventors:Daniel B. YaroshLieve DeclercqYoko NikiNaoaki Saito
A61P 43/00A61K 31/20A61K 38/005A61K 2800/782A61K 8/64A61K 45/06A61Q 19/02A61Q 5/08A61Q 5/10A61K 38/06A61P 17/00A61K 8/361A61K 8/66A61Q 17/04A61K 38/08A61Q 19/00A61Q 5/00
48
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Claims

Abstract

Compositions and methods for modulating melanogenesis by modifying tyrosinase palmitoylation are provided.

Claims

exact text as granted — not AI-modified
1 - 10 . (canceled) 
     
     
         11 . A cosmetic or dermatological composition for increasing the appearance of melanin in mammalian skin or hair, comprising a melanin increasing-effective amount of at least one inhibitor of DHHC 2, 3, 7, 15, 6, 11, 17, 21, or 22, in a cosmetically or dermatologically acceptable vehicle. 
     
     
         12 . The cosmetic or dermatological composition of  claim 11  wherein the at least one inhibitor is  2 -BP. 
     
     
         13 . A cosmetic or dermatological composition for reducing the appearance of melanin in mammalian skin or hair, comprising a melanin reducing-effect amount of at least one inhibitor of PPT in a cosmetically or dermatologically acceptable vehicle. 
     
     
         14 . The cosmetic or dermatological composition according to  claim 13  wherein the at least one inhibitor of PPT comprises at least one peptide containing at least one palmitoylated amino acid. 
     
     
         15 . The cosmetic or dermatological composition according to  claim 14  wherein the at least one inhibitor of PPT comprises PP1. 
     
     
         16 . The cosmetic or dermatological composition according to  claim 14  wherein the at least one inhibitor of PPT comprises PP2. 
     
     
         17 . A cosmetic or dermatological composition for reducing the appearance of melanin in mammalian skin or hair comprising a melanin reducing-effective amount of at least one palmitoylated peptide in a cosmetically or dermatologically acceptable vehicle, and an additional whitening active. 
     
     
         18 . A cosmetic or dermatological composition for reducing the appearance of melanin in mammalian skin or hair comprising a melanin reducing-effective amount of at least one palmitoylated peptide that comprises PP1, in a cosmetically or dermatologically acceptable vehicle. 
     
     
         19 . A cosmetic or dermatological composition for reducing the appearance of melanin in mammalian skin or hair comprising a melanin reducing-effective amount of at least one palmitoylated peptide that comprises PP2, in a cosmetically or dermatologically acceptable vehicle. 
     
     
         20 . (canceled)

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