1,7-diazacarbazoles and methods of use

Abstract

The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

We claim: 
     
         1 . A compound of formula (I), (I-a), or (I-b), or a solvate, hydrate or salt thereof: 
       
         
           
           
               
               
           
         
         X is CR 2  or N; 
         Y is CR 4  or N; 
         Z is CR 8  or N; provided that no more than one of X, Y and Z is N at the same time; 
         R 2  is H, halo, CN, CF 3 , —OCF 3 , OH, —NO 2 , C 1 -C 5  alkyl, —O(C 1 -C 5  alkyl), —S(C 1 -C 5  alkyl), or N(R 22 ) 2 ; 
         R 3  is H, halo, CN, —O—R 9 , —N(R 22 )—R 9 , —S(O) p —R 9 , or R 9 ; 
         p is 0, 1 or 2; 
         R 4  is H, halo, CN, CF 3 , —OCF 3 , OH, —NO 2 , —(CR 14 R 15 ) n C(═Y′)OR 11 , —(CR 14 R 15 ) n C(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n NR 11 R 12 , —(CR 14 R 15 ) n OR 11 , —(CR 14 R 15 ) n S(O) p R 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)R 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)OR 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n NR 12 SO 2 R 11 , —(CR 14 R 15 ) n OC(═Y′)R 11 , —(CR 14 R 15 ) n OC(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n S(O) 2 NR 11 R 12 , alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 13  groups; 
         each n is independently 0-5; 
         R 5  is H, halo, CN, CF 3 , —OCF 3 , OH, —NO 2 , —(CR 14 R 15 ) n C(═Y′)OR 11 , —(CR 14 R 15 ) n C(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n NR 12 C(═Y′)R 11 , —(CR 14 R 15 ) n NR 11 R 12 , —(CR 14 R 15 ) n OR 11 , —(CR 14 R 15 ) n S(O) p R 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)OR 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n NR 12 SO 2 R 11 , —(CR 14 R 15 ) n OC(═Y′)R 11 , —(CR 14 R 15 ) n OC(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n S(O) 2 NR 11 R 12 , alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl wherein the said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 13  groups; 
         R 6  is H, CN, —CF 3 , —OCF 3 , halo, —C(═Y′)OR 11 , —C(═Y′)NR 11 R 12 , —OR 11 , —OC(═Y′)R 11 , —NR 11 R 12 , —NR 12 C(═Y′)R 11 , —NR 12 C(═Y′)NR 11 R 12 , —NR 12 S(O) q R 11 , —SR 11 , —S(O)R 11 , —S(O) 2 R 11 , —OC(═Y′)NR 11 R 12 , —S(O) 2 NR 11 R 12 , alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted by one to four R 13  groups; 
         R 7  is H, OH, CN, O(C 1 -C 3  alkyl), or C 1 -C 4  alkyl, wherein each said alkyl is optionally substituted with one to three groups independently selected from halo, N(R 22 ) 2  or OR 22 ; 
         R 8  is H, halo, CN, NO 2 , N(R 22 ) 2 , OH, O(C 1 -C 3  alkyl), or C 1 -C 3  alkyl, wherein each said alkyl is optionally substituted with one to three fluoro groups; 
         each R 9  is independently alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein each member of R 9  is independently substituted with one to three R 10  groups; 
         each R 10  is independently H, CN, —CF 3 , —OCF 3 , —NO 2 , halo, R 11 , —OR 11 , —NR 12 C(═Y′)R 11 , —NR 12 C(═NR 12 )R 11 , —NR 12 S(O) q R 11 , —SR 11 , —NR 11 R 12 , oxo, —C(═Y′)OR 11 , —C(═Y′)NR 11 R 12 , —S(O) q R 11 , —NR 12 C(═Y′)OR 11 , —NR 12 C(═Y′)NR 11 R 12 , —OC(═Y′)R 11 , —OC(═Y′)NR 11 R 12 , or —S(O) 2 NR 11 R 12 ; 
         each q independently is 1 or 2; 
         R 11  and R 12  are independently H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 13  groups, wherein two geminal R 13  groups are optionally taken together with the atom to which they are attached to form a 3-6 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 18  groups; 
         R 11  and R 12  are optionally taken together with the attached N atom to form a 4-7 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 13  groups; 
         each R 13  is independently halo, CN, CF 3 , —OCF 3 , —NO 2 , oxo, —(CR 14 R 15 ) n C(═Y′)R 16 , —(CR 14 R 15 ) n C(═Y′)OR 16 , —(CR 14 R 15 ) n C(═Y′)NR 16 R 17 , —(CR 14 R 15 ) n NR 16 R 17 , —(CR 14 R 15 ) n OR 16 , —(CR 14 R 15 ) n SR 16 , —(CR 14 R 15 ) n NR 16 C(═Y′)R 17 , —(CR 14 R 15 ) n NR 16 C(═Y′)OR 17 , —(CR 14 R 15 ) n NR 17 C(═Y′)NR 16 R 17 , —(CR 14 R 15 ) n NR 17 SO 2 R 16 , —(CR 14 R 15 ) n OC(═Y′)R 16 , —(CR 14 R 15 ) n OC(═Y′)NR 16 R 17 , —(CR 14 R 15 ) n S(O)R 16 , —(CR 14 R 15 ) n S(O) 2 R 16 , —(CR 14 R 15 ) n S(O) 2 NR 16 R 17 , or R 16 ; 
         R 14  and R 15  are independently selected from H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 18  groups; 
         R 16  and R 17  are independently H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 18  groups; 
         R 16  and R 17  are optionally taken together with the attached N atom to form a 5-6 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 18  groups; 
         each R 18  is independently H, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, halo, CN, CF 3 , —OCF 3 , —NO 2 , oxo, —(CR 19 R 20 ) n C(═Y′)R 23 , —(CR 19 R 20 ) n C(═Y′)OR 23 , —(CR 19 R 20 ) n C(═Y′)NR 23 R 24 , —(CR 19 R 20 ) n NR 23 R 24 , —(CR 19 R 20 ) n OR 23 , —(CR 19 R 20 ) n —SR 23 , —(CR 19 R 20 ) n NR 24 C(═Y′)R 23 , —(CR 19 R 20 ) n NR 24 C(═Y′)OR 23 , —(CR 19 R 20 ) n NR 22 C(═Y′)NR 23 R 24 , —(CR 19 R 20 ) n NR 24 SO 2 R 23 , —(CR 19 R 20 ) n OC(═Y′)R 23 , —(CR 19 R 20 ) n OC(═Y′)NR 23 R 24 , —(CR 19 R 20 ) n S(O)R 23 , —(CR 19 R 20 ) n S(O) 2 R 23 , or —(CR 19 R 20 ) n S(O) 2 NR 23 R 24 , wherein said alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one to four R 21  groups; 
         R 19  and R 20  are independently H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 25  groups; 
         R 23  and R 24  are independently H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 21  groups; 
         R 23  and R 24  are optionally taken together with the attached N atom to form a 5-6 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 21  groups; 
         each R 21  is independently H, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, halo, CN, CF 3 , —OCF 3 , —NO 2 , oxo, —C(═Y′)R 25 , —C(═Y′)OR 25 , —C(═Y′)NR 25 R 26 , —NR 25 R 26 , —OR 25 , —SR 25 , —NR 26 C(═Y′)R 25 , —NR 26 C(═Y′)OR 25 , —NR 22 C(═Y′)NR 25 R 26 , —NR 26 SO 2 R 25 , —OC(═Y′)R 25 , —OC(═Y′)NR 25 R 26 , —S(O)R 25 , —S(O) 2 R 25 , or —S(O) 2 NR 25 R 26 , wherein said alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one to four R 25  groups; 
         each R 25  and R 26  is independently H, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one to four groups selected from halo, —CN, —OCF 3 , —CF 3 , —NO 2 , —C 1 -C 6  alkyl, —OH, oxo, —SH, —O(C 1 -C 6  alkyl), —S(C 1 -C 6  alkyl), —NH 2 , —NH(C 1 -C 6  alkyl), —N(C 1 -C 6  alkyl) 2 , —SO 2 (C 1 -C 6  alkyl), —CO 2 H, —CO 2 (C 1 -C 6  alkyl), —C(O)NH 2 , —C(O)NH(C 1 -C 6  alkyl), —C(O)N(C 1 -C 6  alkyl) 2 , —N(C 1 -C 6  alkyl)C(O)(C 1 -C 6  alkyl), —NHC(O)(C 1 -C 6  alkyl), —NHSO 2 (C 1 -C 6  alkyl), —N(C 1 -C 6  alkyl)SO 2 (C 1 -C 6  alkyl), —SO 2 NH 2 , —SO 2 NH(C 1 -C 6  alkyl), —SO 2 N(C 1 -C 6  alkyl) 2 , —OC(O)NH 2 , —OC(O)NH(C 1 -C 6  alkyl), —OC(O)N(C 1 -C 6  alkyl) 2 , —NHC(O)NH(C 1 -C 6  alkyl), —NHC(O)N(C 1 -C 6  alkyl) 2 , —N(C 1 -C 6  alkyl)C(O)NH(C 1 -C 6  alkyl), —N(C 1 -C 6  alkyl)C(O)N(C 1 -C 6  alkyl) 2 , —NHC(O)NH(C 1 -C 6  alkyl), —NHC(O)N(C 1 -C 6  alkyl) 2 , —NHC(O)O(C 1 -C 6  alkyl), and —N(C 1 -C 6  alkyl)C(O)O(C 1 -C 6  alkyl); 
         R 25  and R 26  are optionally taken together with the attached N atom to form a 5-6 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four groups selected from halo, —CN, —OCF 3 , CF 3 , —NO 2 , —C 1 -C 6  alkyl, —OH, oxo, —SH, —O(C 1 -C 6  alkyl), —S(C 1 -C 6  alkyl), —NH 2 , —NH(C 1 -C 6  alkyl), —N(C 1 -C 6  alkyl) 2 , —SO 2 (C 1 -C 6  alkyl), —CO 2 H, —CO 2 (C 1 -C 6  alkyl), —C(O)NH 2 , —C(O)NH(C 1 -C 6  alkyl), —C(O)N(C 1 -C 6  alkyl) 2 , —N(C 1 -C 6  alkyl)C(O)(C 1 -C 6  alkyl), —NHC(O)(C 1 -C 6  alkyl), —NHSO 2 (C 1 -C 6  alkyl), —N(C 1 -C 6  alkyl)SO 2 (C 1 -C 6  alkyl), —SO 2 NH 2 , —SO 2 NH(C 1 -C 6  alkyl), —SO 2 N(C 1 -C 6  alkyl) 2 , —OC(O)NH 2 , —OC(O)NH(C 1 -C 6  alkyl), —OC(O)N(C 1 -C 6  alkyl) 2 , —NHC(O)NH(C 1 -C 6  alkyl), —NHC(O)N(C 1 -C 6  alkyl) 2 , —N(C 1 -C 6  alkyl)C(O)NH(C 1 -C 6  alkyl), —N(C 1 -C 6  alkyl)C(O)N(C 1 -C 6  alkyl) 2 , —NHC(O)NH(C 1 -C 6  alkyl), —NHC(O)N(C 1 -C 6  alkyl) 2 , —NHC(O)O(C 1 -C 6  alkyl), and —N(C 1 -C 6  alkyl)C(O)O(C 1 -C 6  alkyl); 
         Y′ is independently O, NR 22 , or S; 
         each R 22  is independently H or C 1 -C 5  alkyl; and 
         provided that (1) R 2 , R 3 , R 4 , R 5 , R 6 , and R 8  are not H at the same time; and (2) when X is CH, Y is CH, R 5  is H, Z is CR 8 , and R 3  is H or alkyl, then R 6  is not —C(═Y′)OR 11 . 
       
     
     
         2 . The compound of  claim 1  wherein the compound is of Formula (I-a): 
       
         
           
           
               
               
           
         
       
     
     
         3 . The compound of  claim 1  wherein the compound is of Formula (I-b): 
       
         
           
           
               
               
           
         
       
     
     
         4 . The compound of  claim 3  wherein R 3  is H, CH 3  or halo. 
     
     
         5 . The compound of  claim 4  wherein R 4  is —NR 11 R 12  or —OR 11 , wherein R 11  and R 12  are optionally taken together with the attached N atom to form a 4-7 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 13  groups. 
     
     
         6 . The compound of  claim 5  wherein R 4  is selected from one of the following groups: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         7 . The compound of  claim 1  wherein R 5  is —NR 11 R 12  or —OR 11 , wherein R 11  and R 12  are optionally taken together with the attached N atom to form a 4-7 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 13  groups. 
     
     
         8 . The compound of  claim 7  wherein R 5  is selected from one of the following groups: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         9 . The compound of  claim 1  wherein R 6  is H, CN or pyrrolyl optionally substituted with C 1 -C 3  alkyl. 
     
     
         10 . The compound of  claim 1  wherein R 6  is H, CN, N-methylpyrrolyl, or pyrrolyl. 
     
     
         11 . The compound of  claim 1  wherein R 6  is H or CN. 
     
     
         12 . The compound of  claim 1  wherein R 6  is CN. 
     
     
         13 . A compound selected from the group consisting of:
 4-(N-(morpholin-2-ylmethyl))-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(azetidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(morpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(morpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(quinuclidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1s,3s)-cyclobutanamine-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((1-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-((1-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((4-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-((4-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((piperidin-2-one)-5-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1,3-dimethylpiperidin-3-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(2-(pyrrolidin-1-ylmethyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(morpholin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(quinuclidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   trans-4-(4-fluoropiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1R,3S,4S)-2-azabicyclo[2.2.1]heptan-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(2-((dimethylamino)methyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(2-((dimethylamino)methyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(2-((methylamino)methyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(2-((methylamino)methyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-hydroxy-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-fluoro-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-methoxy-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(3-(dimethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(3-(dimethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1r,4r)-4-(dimethylamino)cyclohexyloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((1-methylpiperidin-3-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(4-methylmorpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(1-ethylpyrrolidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-((1-ethylpyrrolidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(3-(ethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(3-(ethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(4-(2-(pyrrolidin-2-yl)acetyl)piperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(4-(2-(pyrrolidin-2-yl)acetyl)piperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   cis-4-(4-fluoropiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   1-[4-(3-Chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrol-4-yl)-piperazin-1-yl]-2-(R)-pyrrolidin-2-yl-ethanone   (S)-3-Chloro-4-(3-hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-((3S,4S)-3,4-dihydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-(3-hydroxyazetidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-hydroxy-3-methylpyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-3-Chloro-4-(3-hydroxy-3-methylpyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-3-Chloro-4-(3-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-(4-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-aminopyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-(methylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Bromo-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Fluoro-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((3-methylpiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(3-(dimethylamino)-2,2-dimethylpropoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(1-(3-fluoropropyl)-4-methylpiperidin-4-yl)methoxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1-(2-hydroxyethyl)-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1-(2-methoxyethyl)-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1-ethyl-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(1-methylpiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((R)-1-ethylpiperidin-3-oxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(1-(2-hydroxyethyl)piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(1-(2-methoxyethyl)piperidin-3-oxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-ethyl-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(piperidin-2-ylmethoxy)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(piperidin-2-ylmethoxy)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((1-ethylpiperidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((1-methylpiperidin-2-yl)methoxy)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(N-(2-methoxyethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(N-(3-fluoropropyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(N-(2-methoxyethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(N-ethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   4-(4-(pyrrolidin-3-yl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(N-methylpyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(N,N-dimethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(N,N-dimethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   4-(octahydropyrrolo[3,4-b]pyrrol)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   4-((3 aS,6 aS)-1-methyloctahydropyrrolo[3,4-b]pyrrol)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   4-((R)-piperidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   3-chloro-4-piperazin-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-(1-ethylpiperazin)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(N-(3-fluoropropyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-(2,2-difluoro ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(N-(pyrrolidin-3-yl)isobutyramide)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(N-(2,2,2-trifluoroethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(Piperidin-3-yloxy)-6-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole;   1-[4-(9H-Dipyrido[2,3b;4′,3′-d]pyrrol-4-yl)-piperazin-1-yl]-2-(R)-pyrrolidin-2-yl-ethanone;   [(S)-1-(9H-Dipyrido[2,3-b;4′,3′-d]pyrrol-4-yl)-pyrrolidin-3-yl]-ethyl-amine;   4-(1-Ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-[(S)-(1-Azabicyclo-[2.2.2]oct-3-yl)oxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((S)-1-Ethylpiperidin-3-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   cis-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-Ethylpiperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-Pyrrolidin-1-ylpiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3b;4′,3′ d]pyrrole-6-carbonitrile;   4-((R)-1-Ethyl-piperidin-3-ylamino)-9H-dipyrido-[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-Methylaminopiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((R)-3-Hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   4-((S)-3-Hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   Trans-3-Fluoropiperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′d]pyrrole-6-carbonitrile;   5-(Piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(Pyrrolidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-Piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((R)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Ethyl-piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile;   5-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-9Hdipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Cyclopropylmethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(Cis)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(1-Ethyl-piperidin-4-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(1-Ethyl-piperidin-4-yl)-methyl-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Butyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(2-Pyrrolidin-1-yl-ethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(trans)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(4-Ethyl-morpholin-2-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Ethylamino-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Oxetan-3-yl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Cyclopropylmethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1,3′]Bipyrrolidinyl-1′-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(3-Fluoro-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-(3-Fluoro-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-(3-Hydroxy-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((S)-3-Fluoro-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Azetidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((R)-3-Fluoropyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6carbonitrile;   5-[4-((S)-3-Hydroxypyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((R)-3-Hydroxy-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-[1,4]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Fluoro-[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-4-methyl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Aza-bicyclo[2.2.2]oct-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1,4-Dimethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-4-methyl[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(1-oxetan-3-yl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-yloxy)-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(4-pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′ d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-azepan-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-azetidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(Piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-piperazin-1-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile;   5-[1-(2,2-Difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Hydroxyethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-yloxy)-3-methyl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and   5-(1-Ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole.   
     
     
         14 . The compound of  claim 13 , where in said compound is selected from the group consisting of:
 4-(N-(morpholin-2-ylmethyl))-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(azetidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(morpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(morpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(quinuclidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1s,3s)-cyclobutanamine-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((1-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-((1-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((4-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-((4-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((piperidin-2-one)-5-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1,3-dimethylpiperidin-3-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(2-(pyrrolidin-1-ylmethyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(morpholin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(quinuclidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   trans-4-(4-fluoropiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1R,3S,4S)-2-azabicyclo[2.2.1]heptan-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(2-((dimethylamino)methyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(2-((dimethylamino)methyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(2-((methylamino)methyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(2-((methylamino)methyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-hydroxy-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-fluoro-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-methoxy-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(3-(dimethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(3-(dimethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1r,4r)-4-(dimethylamino)cyclohexyloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((1-methylpiperidin-3-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(4-methylmorpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(1-ethylpyrrolidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-((1-ethylpyrrolidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(3-(ethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(3-(ethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(4-(2-(pyrrolidin-2-yl)acetyl)piperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(4-(2-(pyrrolidin-2-yl)acetyl)piperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   cis-4-(4-fluoropiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   1-[4-(3-Chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrol-4-yl)-piperazin-1-yl]-2-(R)-pyrrolidin-2-yl-ethanone   (S)-3-Chloro-4-(3-hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-((3S,4S)-3,4-dihydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-(3-hydroxyazetidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-hydroxy-3-methylpyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-3-Chloro-4-(3-hydroxy-3-methylpyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-3-Chloro-4-(3-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-(4-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-aminopyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-(methylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Bromo-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Fluoro-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((3-methylpiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(3-(dimethylamino)-2,2-dimethylpropoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(1-(3-fluoropropyl)-4-methylpiperidin-4-yl)methoxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1-(2-hydroxyethyl)-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-carbonitrile;   4-((1-(2-methoxyethyl)-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1-ethyl-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(1-methylpiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((R)-1-ethylpiperidin-3-oxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(1-(2-hydroxyethyl)piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(1-(2-methoxyethyl)piperidin-3-oxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((4-ethyl-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(piperidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(piperidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((1-ethylpiperidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-((1-methylpiperidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(N-(2-methoxyethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(N-(3-fluoropropyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(N-(2-methoxyethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(N-ethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-(pyrrolidin-3-yl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(N-methylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(N,N-dimethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-4-(N,N-dimethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(octahydropyrrolo[3,4-b]pyrrol)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((3aS,6aS)-1-methyloctahydropyrrolo[3,4-b]pyrrol)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((R)-piperidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-chloro-4-piperazin-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-4-(1-ethylpiperazin)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(N-(3-fluoropropyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(3-(2,2-difluoroethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(N-(pyrrolidin-3-yl)isobutyramide)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (S)-3-Chloro-4-(N-(2,2,2-trifluoroethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   (R)-4-(Piperidin-3-yloxy)-6-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole;   1-[4-(9H-Dipyrido[2,3b;4′,3′-d]pyrrol-4-yl)-piperazin-1-yl]-2-(R)-pyrrolidin-2-yl-ethanone;   [(S)-1-(9H-Dipyrido[2,3-b;4′,3′-d]pyrrol-4-yl)-pyrrolidin-3-yl]-ethyl-amine;   4-(1-Ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-[(S)-(1-Azabicyclo-[2.2.2]oct-3-yl)oxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((S)-1-Ethylpiperidin-3-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   cis-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-Ethylpiperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-Pyrrolidin-1-ylpiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3b;4′,3′ d]pyrrole-6-carbonitrile;   4-((R)-1-Ethyl-piperidin-3-ylamino)-9H-dipyrido-[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   4-(4-Methylaminopiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   4-((R)-3-Hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   4-((S)-3-Hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; and   Trans-3-Fluoropiperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′d]pyrrole-6-carbonitrile.   
     
     
         15 . The compound of  claim 13 , wherein said compound selected from the group consisting of:
 5-(Piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(Pyrrolidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-Piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((R)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Ethyl-piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile;   5-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-9Hdipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Cyclopropylmethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(Cis)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(1-Ethyl-piperidin-4-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(1-Ethyl-piperidin-4-yl)-methyl-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Butyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(2-Pyrrolidin-1-yl-ethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(trans)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(4-Ethyl-morpholin-2-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Ethylamino-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Oxetan-3-yl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Cyclopropylmethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1,3′]Bipyrrolidinyl-1′-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(3-Fluoro-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-(3-Fluoro-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-(3-Hydroxy-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((S)-3-Fluoro-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Azetidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((R)-3-Fluoropyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6carbonitrile;   5-[4-((S)-3-Hydroxypyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((R)-3-Hydroxy-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-[1,4]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Fluoro-[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-4-methyl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Aza-bicyclo[2.2.2]oct-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1,4-Dimethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-4-methyl[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(1-oxetan-3-yl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-yloxy)-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(4-pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′ d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-azepan-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-azetidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(Piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-piperazin-1-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile;   5-[1-(2,2-Difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Hydroxyethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-yloxy)-3-methyl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and   5-(1-Ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole.   
     
     
         16 . The compound of  claim 13 , wherein said compound selected from the group consisting of:
 5-(Piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(Pyrrolidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-Piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((R)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Ethyl-piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile;   5-(1-Cyclopropylmethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(Cis)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Butyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(2-Pyrrolidin-1-yl-ethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(trans)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(3-Fluoro-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-4-methyl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Aza-bicyclo[2.2.2]oct-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1,4-Dimethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(1-oxetan-3-yl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-yloxy)-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′ d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-((S)-1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-azepan-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-azetidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2,2-Difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Hydroxyethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Ethyl-piperidin-4-yloxy)-3-methyl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and   5-(1-Ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole.   
     
     
         17 . The compound of  claim 13 , wherein said compound selected from the group consisting of:
 5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-9Hdipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(1-Ethyl-piperidin-4-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(1-Ethyl-piperidin-4-yl)-methyl-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[(4-Ethyl-morpholin-2-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Oxetan-3-yl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Cyclopropylmethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(1-Methyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and   5-(Piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile.   
     
     
         18 . The compound of  claim 13 , wherein said compound selected from the group consisting of:
 5-[4-(3-Fluoro-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-(3-Hydroxy-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((S)-3-Fluoro-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Azetidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((R)-3-Fluoropyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((S)-3-Hydroxypyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-[4-((R)-3-Hydroxy-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-[1,4]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Fluoro-[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-4-methyl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Hydroxy-4-methyl[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile;   3-Fluoro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Bromo-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   3-Chloro-5-(4-pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile;   5-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and   5-piperazin-1-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile.   
     
     
         19 . A pharmaceutical composition comprising a compound of  claim 1  and a pharmaceutically acceptable carrier. 
     
     
         20 . The pharmaceutical composition of  claim 19 , further comprising a second chemotherapeutic agent. 
     
     
         21 . The pharmaceutical composition of  claim 20 , wherein said second chemotherapeutic agent is a DNA damaging agent. 
     
     
         22 . A method of inhibiting abnormal cell growth or treating a hyperproliferative disorder in a mammal comprising administering to said mammal a therapeutically effective amount of a pharmaceutical composition of  claim 19 . 
     
     
         23 . The method of treating cancer in a mammal comprising administering to said mammal a therapeutically effective amount of a pharmaceutical composition of  claim 19 . 
     
     
         24 . The method of  claim 23 , wherein cancer is selected from breast cancer, colorectal cancer, ovarian cancer, non-small cell lung cancer, malignant brain tumors, sarcomas, melanoma, lymphoma, myelomas and leukemia.