Method for predicting responsiveness to drugs

Abstract

The present invention provides a novel method to determine the likelihood of effectiveness of a treatment in an individual affected with or at risk for developing cancer. The method involves detecting the presence or absence of Met amplification in an individual. The presence of Met amplification indicates that a Met targeting treatment is likely to be effective. Preferably, the Met targeting treatment is PHA-665752 or PF-02341066. In addition, the present methods allow for the detection of cancer in an individual, wherein the presence of Met amplification indicates that cancer is present and further that it will be treatable, namely with a Met targeting treatment.

1 . A method for identifying a cancer in an individual that is susceptible to treatment comprising:
 a. isolating a biological sample from an individual; and   b. detecting the presence or absence of amplification of the Met gene, wherein the presence of amplification indicates that the cancer is susceptible to treatment.