US2014161890A1PendingUtilityA1

MULTIFUNCTIONAL Fe3O4 CORED MAGNETIC-QUANTUM DOT FLUORESCENT NANOCOMPOSITES FOR RF NANO-HYPERTHERMIA OF CANCER CELLS

59
Assignee: UNIV ARKANSASPriority: Mar 26, 2010Filed: Feb 17, 2014Published: Jun 12, 2014
Est. expiryMar 26, 2030(~3.7 yrs left)· nominal 20-yr term from priority
Inventors:Alexandru S. BirisYang XuDaoyuan Wang
A61K 41/0052B82Y 5/00A61K 49/1836A61K 49/0067B82Y 30/00A61K 41/0047A61N 1/406B82Y 40/00H01F 1/0054
59
PatentIndex Score
0
Cited by
0
References
0
Claims

Abstract

A magnetic oxide-quantum dot nanocomposite has at least one magnetic oxide nanoparticle coated with a silica (SiO 2 ) shell and terminated with at least one thiol group (—SH) and at least one CdSe/ZnS quantum dot linked with the at least one SiO 2 -coated magnetic oxide nanoparticle via the at least one thiol group. The at least one magnetic oxide nanoparticle can be an iron oxide (Fe 3 O 4 ) nanoparticle. A method of cancer treatment using the magnetic oxide-quantum dot nanocomposites, includes the steps of delivering a plurality of nmagnetic oxide-quantum dot nanocomposites to a cancer cell, and subjecting the cancer cell with the plurality of magnetic oxide-quantum dot nanocomposites to a radio frequency induction for a period of time effective to cause the cancer cell to die.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A magnetic oxide-quantum dot nanocomposite, comprising:
 (a) at least one magnetic oxide nanoparticle coated with a silica (SiO 2 ) shell and terminated with at least one thiol group (—SH); and   (b) at least one CdSe/ZnS quantum dot linked with the at least one SiO 2 -coated magnetic oxide nanoparticle via the at least one thiol group.   
     
     
         2 . The magnetic oxide-quantum dot nanocomposite of  claim 1 , wherein the at least one magnetic oxide nanoparticle comprises at least one iron oxide (Fe 3 O 4 ) nanoparticle. 
     
     
         3 . The magnetic oxide-quantum dot nanocomposite of  claim 1 , wherein the at least one magnetic oxide nanoparticle has a size of about 10 nm. 
     
     
         4 . The magnetic oxide-quantum dot nanocomposite of  claim 1 , wherein the weight ratio between the at least one magnetic oxide nanoparticle and the at least one CdSe/ZnS quantum dot is about 20%. 
     
     
         5 . The magnetic oxide-quantum dot nanocomposite of  claim 1 , wherein the silica (SiO 2 ) shell is about 4 nm thick. 
     
     
         6 . The magnetic oxide-quantum dot nanocomposite of  claim 1 , wherein the at least one CdSe/ZnS quantum dot is coated with mercaptopropionic acid (MPA). 
     
     
         7 . The magnetic oxide-quantum dot nanocomposite of  claim 1 , wherein the at least one CdSe/ZnS quantum dot has a size of about 5 nm. 
     
     
         8 . A method of cancer treatment using magnetic oxide-quantum dot nanocomposites, comprising the steps of:
 (a) delivering a plurality of nmagnetic oxide-quantum dot nanocomposites to a cancer cell, wherein each of the plurality of magnetic oxide-quantum dot nanocomposites comprises: (i) at least one magnetic oxide nanoparticle coated with a silica (SiO 2 ) shell and terminated with at least one thiol group (—SH), and (ii) at least one CdSe/ZnS quantum dot linked with the at least one SiO 2 -coated magnetic oxide nanoparticle via the at least one thiol group; and   (b) subjecting the cancer cell with the plurality of magnetic oxide-quantum dot nanocomposites to a radio frequency induction for a period of time effective to cause the cancer cell to die.   
     
     
         9 . The method of  claim 8 , wherein the at least one magnetic oxide nanoparticle comprises at least one iron oxide (Fe 3 O 4 ) nanoparticle. 
     
     
         10 . The method of  claim 8 , wherein the weight ratio between the at least one magnetic oxide nanoparticle and the at least one CdSe/ZnS quantum dot is about 20%. 
     
     
         11 . The method of  claim 8 , wherein the at least one magnetic oxide nanoparticle has a size of about 10 nm. 
     
     
         12 . The method of  claim 8 , wherein the silica (SiO 2 ) shell is about 4 nm thick. 
     
     
         13 . The method of  claim 8 , wherein the at least one CdSe/ZnS quantum dot is coated with mercaptopropionic acid (MPA). 
     
     
         14 . The method of  claim 8 , wherein the at least one CdSe/ZnS quantum dot has a size of about 5 nm. 
     
     
         15 . The method of  claim 8 , wherein the radio frequency induction has a frequency of about 350 kHz. 
     
     
         16 . The method of  claim 8 , wherein the period of time ranges from about 2 minutes to about 10 minutes for a radio frequency induction of about 5 kW power. 
     
     
         17 . The method of  claim 8 , wherein the plurality of magnetic oxide-quantum dot nanocomposites is dissolved in a solution prior to being delivered to the cancer cell. 
     
     
         18 . The method of  claim 17 , wherein the plurality of magnetic oxide-quantum dot nanocomposites in the solution corresponds to a concentration of less than about 50 μg/ml. 
     
     
         19 . The method of  claim 18 , wherein the plurality of magnetic oxide-quantum dot nanocomposites in the solution corresponds to a concentration ranging from about 0.83 μg/ml to about 1.66 μg/ml. 
     
     
         20 . The method of  claim 8 , wherein the cancer cell comprises a pancreatic cancer cell.

Join the waitlist — get patent alerts

Track US2014161890A1 — get alerts on status changes and closely related new filings.

We store only your email — no account needed. See our privacy policy.