Multi-nutrient supplement and uses thereof

Abstract

Various embodiments of the invention relate to compositions comprising vitamins, minerals and trace elements, antioxidants, amino acids, probiotics, and other components and methods for using such compositions to treat or prevent diseases associated with oxidative stress, including cardiovascular disease.

What is claimed is: 
     
         1 . A method for treating or prevent a disease and/or condition associated with oxidative stress comprising administering to a human subject a therapeutically effective amount of a composition comprising vitamin A, vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 6 , vitamin B 12 , vitamin C, vitamin D, vitamin E, vitamin K, folic acid, calcium source, potassium source, magnesium source, phosphate source, iodine, copper source, chromium source, manganese source, molybdenum source, selenium source, zinc source, one or more tocopherols or salts thereof, lycopene, one or more carotenoids, one or more flavonoids, biotin, inositol, choline, one or more amino acids, a probiotic composition comprising the powder of one or more dried fruits and pollen extract, and fish oil. 
     
     
         2 . The method of  claim 1 , wherein the treating comprises preventing the progression of a disease and/or condition associated with oxidative stress. 
     
     
         3 . The method of  claim 1 , wherein the disease and/or condition associated with oxidative stress is selected from the group consisting of cardiovascular disease, cancer, type-2 diabetes mellitus, atherosclerosis, chronic inflammatory conditions, ischemia/reperfusion injury, sepsis, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, heart failure, myocardial infarction, schizophrenia, bipolar disorder, fragile X syndrome, sickle cell disease, lichen planus, vitiligo, autism, chronic fatigue syndrome, and combinations thereof. 
     
     
         4 . The method of  claim 3 , wherein the disease and/or condition associated with oxidative stress is cardiovascular disease. 
     
     
         5 . The method of  claim 4 , wherein the cardiovascular disease is at least one of atherosclerosis, heart infarct, and stroke. 
     
     
         6 . The method of  claim 1 , wherein the composition comprises vitamin A (0.01-10 mg), vitamin B 1  (1-50 mg), vitamin B 2  (1-50 mg), vitamin B 3  (1-100 mg), vitamin B 5  (1-100 mg), vitamin B 6  (0.5-50 mg), vitamin B 12  (0.0001-2 mg), vitamin C (0.1-1000 mg), vitamin D (0.0001-1 mg), vitamin E (1-500 mg), vitamin K (0.001-5 mg), folic acid (0.0001-5 mg), calcium source (0.1-1000 mg), potassium source (0.1-1000 mg), magnesium source (0.1-1000 mg), phosphate source (1-500 mg), iodine source (0.0001-5 mg), copper source (0.0001-10 mg), chromium source (0.0001-10 mg), manganese source (0.0001-50 mg), molybdenum source (0.0001-10 mg), selenium source (0.0001-10 mg), zinc source (0.001-50 mg), lycopene (0.0001-20 mg), one or more carotenoids (0.0001-20 mg), one or more flavonoids (1-500 mg), biotin (0.0001-20 mg), inositol (0.001-100 mg), choline (0.0001-500 mg), one or more amino acids (0.0001-100 g), a probiotic composition (1-10 mL) comprising the powder of one or more dried fruits (0.0001-2000 mg) and pollen extract (1-10,000 mg), and fish oil (0.0001-20 g). 
     
     
         7 . The method of  claim 6 , wherein the composition comprises an additional amount of vitamin D such that the total amount of vitamin D is 0.0004-4 mg vitamin D. 
     
     
         8 . The composition of  claim 6 , wherein the composition comprises an additional amount of at least one of vitamin C, a potassium source, a magnesium source, and a calcium source. 
     
     
         9 . The method of  claim 1 , wherein the probiotic composition comprises at least one lactic acid bacterium or a culture thereof, inulin, and dried powder of blueberries. 
     
     
         10 . The method of  claim 9 , wherein the at least one lactic acid bacterium comprises  Lactococcis lactus, Lactobacillus rhamnosus , or cultures and combinations thereof. 
     
     
         11 . The method of  claim 1 , wherein the composition comprises vitamin A, vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 6 , vitamin B 12 , vitamin C, vitamin D, vitamin E, vitamin K, folic acid, potassium chloride, magnesium oxide, dicalcium phosphate, iodine, copper gluconate, chromium sulfate, manganese gluconate, potassium molybdate, selenomethionine, zinc lactate, d-alpha-tocopherol acetate, lycopene, beta-carotene, citrus flavonoids, L-cysteine or N-acetyl cysteine, L-arginine, a probiotic composition comprising dried powder of blueberries and pollen extract, d-biotin, inositol, choline-L-bitartarate, and fish oil. 
     
     
         12 . A method of delaying or preventing the onset of a disease and/or condition associated with oxidative stress comprising administering to a human subject a therapeutically effective amount of a composition comprising vitamin A, vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 6 , vitamin B 12 , vitamin C, vitamin D, vitamin E, vitamin K, folic acid, calcium source, potassium source, magnesium source, phosphate source, iodine, copper source, chromium source, manganese source, molybdenum source, selenium source, zinc source, lycopene, one or more carotenoids, one or more flavonoids, biotin, inositol, choline, one or more amino acids, a probiotic composition comprising the powder of one or more dried fruits and pollen extract, and fish oil. 
     
     
         13 . A composition comprising:
 (v) vitamin A, vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 6 , vitamin B 12 , vitamin C, vitamin D, vitamin E, vitamin K, folic acid, calcium source, potassium source, magnesium source, phosphate source, iodine, copper source, chromium source, manganese source, molybdenum source, selenium source, zinc source, lycopene, one or more carotenoids, one or more flavonoids, biotin, inositol, choline, one or more amino acids,   (vi) a probiotic composition comprising the powder of one or more dried fruits and pollen extract,   (vii) fish oil, and   (viii) one or more pharmaceutically acceptable excipients.   
     
     
         14 . The composition of  claim 13 , wherein the composition is in the form of a tablet, powder, liquid, capsule or combinations thereof. 
     
     
         15 . The composition of  claim 13 , wherein components (i) and (iv) are comprised in the same dosage unit, separate from the probiotic composition and the fish oil. 
     
     
         16 . The composition of  claim 13 , wherein the dosage unit is one or more tablets, caplets, capsules, tablet-within-a-tablet, tablet/caplet/capsule-within-a-capsule, soft gel capsules, liquid caps or sachets. 
     
     
         17 . The composition of  claim 13 , wherein the composition comprises vitamin A (0.01-10 mg), vitamin B 1  (1-50 mg), vitamin B 2  (1-50 mg), vitamin B 3  (1-100 mg), vitamin B 5  (1-100 mg), vitamin B 6  (0.5-50 mg), vitamin B 12  (0.0001-2 mg), vitamin C (0.1-1000 mg), vitamin D (0.0001-1 mg), vitamin E (1-500 mg), vitamin K (0.001-5 mg), folic acid (0.0001-5 mg), calcium source (0.1-1000 mg), potassium source (0.1-1000 mg), magnesium source (0.1-1000 mg), phosphate source (1-500 mg), iodine source (0.0001-5 mg), copper source (0.0001-10 mg), chromium source (0.0001-10 mg), manganese source (0.0001-50 mg), molybdenum source (0.0001-10 mg), selenium source (0.0001-10 mg), zinc source (0.001-50 mg), lycopene (0.0001-20 mg), one or more carotenoids (0.0001-20 mg), one or more flavonoids (1-500 mg), biotin (0.0001-20 mg), inositol (0.001-100 mg), choline (0.0001-500 mg), one or more amino acids (0.0001-100 g), a probiotic composition (1-10 mL) comprising the powder of one or more dried fruits (0.0001-2000 mg) and pollen extract (1-10,000 mg), and fish oil (0.0001-20 g). 
     
     
         18 . The composition of  claim 13 , wherein the composition comprises an additional amount of vitamin D such that the total amount of vitamin D is 0.0004-4 mg vitamin D. 
     
     
         19 . The composition of  claim 13 , wherein the composition comprises an additional amount of at least one of vitamin C, a potassium source, a magnesium source, and a calcium source. 
     
     
         20 . The composition of  claim 13 , wherein the probiotic composition comprises at least one lactic acid bacterium or a culture thereof, inulin, and dried powder of blueberries. 
     
     
         21 . The composition of  claim 20 , wherein the at least one lactic acid bacterium comprises  Lactococcis lactus, Lactobacillus rhamnosus , or cultures and combinations thereof. 
     
     
         22 . The composition of  claim 13 , wherein the composition comprises vitamin A, vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 6 , vitamin B 12 , vitamin C, vitamin D, vitamin E, vitamin K, folic acid, potassium chloride, magnesium oxide, dicalcium phosphate, iodine, copper gluconate, chromium sulfate, manganese gluconate, potassium molybdate, selenomethionine, zinc lactate, lycopene, beta-carotene, citrus flavonoids, L-cysteine or N-acetyl cysteine, L-arginine, a probiotic composition comprising dried powder of blueberries and pollen extract, d-biotin, inositol, choline-L-bitartarate, and fish oil. 
     
     
         23 . A kit comprising the composition of  claim 13  in a suitable container. 
     
     
         24 . The kit of  claim 23 , wherein the composition is comprised in a dosage unit. 
     
     
         25 . The kit of  claim 24 , wherein the dosage unit is one or more tablets, caplets, capsules, tablet-within-a-tablet, tablet/caplet/capsule-within-a-capsule, soft gel capsules, liquid caps or sachets. 
     
     
         26 . The kit of  claim 23 , wherein the composition comprises vitamin A, vitamin B 1 , vitamin B 2 , vitamin B 3 , vitamin B 5 , vitamin B 6 , vitamin B 12 , vitamin C, vitamin D, vitamin E, vitamin K, folic acid, potassium chloride, magnesium oxide, dicalcium phosphate, iodine, copper gluconate, chromium sulfate, manganese gluconate, potassium molybdate, selenomethionine, zinc lactate, lycopene, beta-carotene, citrus flavonoids, L-cysteine or N-acetyl cysteine, L-arginine, a probiotic composition comprising dried powder of blueberries and pollen extract, d-biotin, inositol, choline-L-bitartarate, and fish oil in amounts sufficient to treat or prevent a disease and/or condition associated with oxidative stress.