Compositions and methods of treatment for psoriasis

Abstract

The present invention provides for a composition comprising a tryptamine based drug that acts as a 5-hydroxytryptamine-1 inhibitor in an amount sufficient to reduce the effects of psoriasis and wherein the composition is formulated for topical or oral administration.

1 . A composition for treating psoriasis, the composition comprising a tryptamine based drug that acts as a 5-hydroxytryptamine-1 inhibitor formulated for topical application and in a in a therapeutically effective amount from about 0.01% to about 1% weight and sufficient to reduce the effects of psoriasis. 
     
     
         2 . The composition of  claim 2  wherein the tryptamine based drug is selected from the group consisting of rizatriptan, eletriptan, naratriptan, zolmitriptan, frovatriptan, sumatriptan, almotriptan or salts thereof. 
     
     
         3 . A composition for the treatment of psoriasis comprising:
 at least one tryptamine based drug that acts as a 5-hydroxytryptamine-1 inhibitor in a concentration of about 0.01% to about 1%; and at least three of the following components selected from the group consisting of   at least one emollient in a concentration of in a concentration of about 5% to about 60%;   at least one thickener in a concentration of about 0.5% to about 20%;   at least one preservative in a concentration of about 0.01% to about 10%;   at least one moisturizer in a concentration of about 0.01% to about 10%;   at least one surfactant in a concentration of about 1% to about 20%;   at least one antimicrobial in a concentration of about 0.01% to about 2%;   and water from about 2% to 80%   
     
     
         4 . The composition of  claim 3  wherein the tryptamine based drug is selected from the group consisting of rizatriptan, eletriptan, naratriptan, zolmitriptan, frovatriptan, sumatriptan, alm)triptan or salts thereof.