Antimicrobial Compositions

Abstract

This invention provides antimicrobial compositions containing methylglyoxal and material with methylglyoxal contained (such as manuka honey). The antimicrobial activity of methylglyoxal, or of material with a methylglyoxal presence, is maintained and/or enhanced by mixing methylglyoxal or material with a methyglyoxal presence with cyclodextrin. Methods of preparing such compositions, including powder composition, and methods of using such compositions are also provided.

1 . An antimicrobial composition comprising methylglyoxal and cyclodextrin. 
     
     
         2 . The antimicrobial composition according to  claim 1  wherein the methylglyoxal is comprised in manuka honey. 
     
     
         3 . The antimicrobial composition according to  claim 2  wherein the manuka honey content of the composition is within the range of about 10.0 to about 99.0% wt. 
     
     
         4 . The antimicrobial composition according to  claim 2  wherein the manuka honey has a methylglyoxal concentration of greater than about 30 mg/kg. 
     
     
         5 . The antimicrobial composition according to  claim 2  wherein the manuka honey has a methylglyoxal concentration of greater than about 100 mg/kg. 
     
     
         6 . The antimicrobial composition according to  claim 2  wherein the manuka honey has a methylglyoxal concentration of greater than about 1000 mg/kg. 
     
     
         7 . The antimicrobial composition according to  claim 2  wherein the manuka honey has a methylglyoxal concentration of greater than about 1500 mg/kg. 
     
     
         8 . The antimicrobial composition according to  claim 2  wherein the manuka honey has a methylglyoxal concentration of greater than about 1900 mg/kg. 
     
     
         9 . The antimicrobial composition according to  claim 2  wherein the manuka honey has an NPA rating greater than 10. 
     
     
         10 . The antimicrobial composition according to  claim 2  wherein the manuka honey has an NPA rating greater than 15. 
     
     
         11 . The antimicrobial composition according to  claim 2  wherein the manuka honey has an NPA rating greater than 25. 
     
     
         12 . The antimicrobial composition according to  claim 2  wherein the manuka honey has an NPA rating greater than 35. 
     
     
         13 . The antimicrobial composition according to  claim 1  wherein the cyclodextrin is alpha-cyclodextrin, gamma-cyclodextrin, or a combination of alpha-cyclodextrin and gamma-cyclodextrin. 
     
     
         14 . The antimicrobial composition according to  claim 1  wherein the methylglyoxal content of the antimicrobial composition is within the range of about 0.003% wt to about 0.15% wt. 
     
     
         15 . The antimicrobial composition according to  claim 1  wherein the composition is a consumer good, an industrial product, a food, drink, food additive, drink additive, dietary supplement, nutritional product, medical food, medical device, medical supply, nutraceutical, medicament or a pharmaceutical composition. 
     
     
         16 . The antimicrobial composition according to  claim 15  wherein the composition is a pharmaceutical composition formulated for oral, topical, or parenteral administration. 
     
     
         17 . The antimicrobial composition according to  claim 1  wherein the composition comprises one or more additional antimicrobial agents. 
     
     
         18 . A method of treating or preventing a microbial disease or disorder, the method comprising administering to a subject in need thereof the composition of  claim 1 . 
     
     
         19 . The method according to  claim 18  wherein the composition comprising methylglyoxal and cyclodextrin comprises manuka honey 
     
     
         20 . An antimicrobial composition comprising manuka honey and cyclodextrin.