Eyelid Margin Wipes Comprising Chemical Means for Temperature Adjustment

Abstract

An eyelid margin wipe comprising chemical means for adjusting the temperature of the wipe relative to the ambient temperature. The wipe is particularly useful for treatment of disorders of the eyelid or eyelid margin such as meibomian gland dysfunction.

What is claimed is: 
     
         1 - 40 . (canceled) 
     
     
         41 . An eyelid wipe for treatment of a disorder of an eye, eyelid, or eyelid margin, comprising:
 a) at least two components adapted to lower a temperature of the eyelid wipe from an ambient temperature to a desired temperature upon a reaction of the at least two components,   b) a water-impermeable container for preventing the at least two components from coming into contact with a closed eye when in use,   c) a seal for keeping the at least two components separate until a temperature change is initiated, and   d) at least one agent selected from the group consisting of soothing agents, cleansing agents, and surfactant agents.   
     
     
         42 . The eyelid wipe of  claim 41 , wherein the disorder is blepharitis, dryness, irritation, redness, inflammation, meibomian gland dysfunction, hay fever, a condition associated with use of eye cosmetics, or a condition associated with contact-lens wear. 
     
     
         43 . The eyelid wipe of  claim 41 , wherein the reaction is an endothermic reaction. 
     
     
         44 . The eyelid wipe of  claim 41 , wherein one of the at least two components is a hydratable inorganic salt. 
     
     
         45 . The eyelid wipe of  claim 41 , wherein one of the at least two components is NH 4 NO 3 . 
     
     
         46 . The eyelid wipe of  claim 41 , wherein the at least two components comprise NH 4 NO 3  and water. 
     
     
         47 . The eyelid wipe of  claim 41 , wherein the at least two components comprise an oxidising agent and a reducing agent. 
     
     
         48 . The eyelid wipe of  claim 41 , wherein the desired temperature is from about 0° C. to about 25° C. 
     
     
         49 . The eyelid wipe of  claim 41 , wherein the desired temperature is from about 5° C. to about 10° C. 
     
     
         50 . The eyelid wipe of  claim 41 , wherein the desired temperature is reached within 2 minutes after the temperature change is initiated. 
     
     
         51 . The eyelid wipe of  claim 41 , wherein the desired temperature is reached within 1 minute after the temperature change is initiated. 
     
     
         52 . The eyelid wipe of  claim 41 , wherein the desired temperature is reached in less than about 60 seconds after the temperature change is initiated. 
     
     
         53 . The eyelid wipe of  claim 41 , wherein the desired temperature is reached in from about 30 to about 60 seconds after the temperature change is initiated. 
     
     
         54 . The eyelid wipe of  claim 41 , wherein the desired temperature is maintained for at least about 5 minutes. 
     
     
         55 . The eyelid wipe of  claim 41 , wherein the desired temperature is maintained for at least about 8 minutes. 
     
     
         56 . The eyelid wipe of  claim 41 , wherein the desired temperature is maintained for at least about 10 minutes. 
     
     
         57 . The eyelid wipe of  claim 41 , wherein the desired temperature is maintained for from about 5 minutes to about 30 minutes. 
     
     
         58 . The eyelid wipe of  claim 41 , wherein the eyelid wipe is sterile. 
     
     
         59 . The eyelid wipe of  claim 41 , wherein the eyelid wipe is square, rectangular, circular, ovoid, eye-shaped, curved to correspond to a contour of an eye, sized to be used on one eye region, or sized to be used on two eyes simultaneously. 
     
     
         60 . The eyelid wipe of  claim 41 , further comprising a band, a pocket, or a layer for holding the eyelid wipe for a period of time. 
     
     
         61 . The eyelid wipe of  claim 60 , comprising the band that is elastic. 
     
     
         62 . The eyelid wipe of  claim 41 , further comprising an adhesive portion on a part or the whole of one side of the eyelid wipe. 
     
     
         63 . The eyelid wipe of  claim 62 , wherein the adhesive portion comprises one or more adhesive materials selected from the group consisting of acrylic adhesives, hydrocolloidal or hydrogel adhesives, natural rubber, synthetic rubber, and any combination thereof. 
     
     
         64 . The eyelid wipe of  claim 41 , further comprising a removal strip to protect an adhesive portion. 
     
     
         65 . The eyelid wipe of  claim 64 , wherein the removal strip is a polymer or paper strip treated with silicone. 
     
     
         66 . The eyelid wipe of  claim 41 , wherein the eyelid wipe is coated with a polymeric material capable of moulding to a surface of an eye. 
     
     
         67 . The eyelid wipe of  claim 41 , wherein the seal is a frangible seal. 
     
     
         68 . The eyelid wipe of  claim 41 , wherein the at least one agent is at least one cleansing agent or at least one surfactant agent. 
     
     
         69 . The eyelid wipe of  claim 41 , wherein the at least one agent is PEG-80 sorbitan laurate, sodium trideceth sulfate, PEG-150 distearate, cocamidopropyl hydroxysultaine, sodium laureth-13 carboxylate, disodium lauroamphodiacetate, polysorbate 80, polysorbate 20, poloxamer 184, ammonium laureth sulfate, ceteareth 20, ceteareth 25, cocamidopropyl betaine, disodium laureth sulfosuccinate, disodium lauriminodipropionate, disodium lauroamphodipropionate, glycol stearate, hydrogenated castor oil, laureth-23, magnesium laureth, oleth sulfate, PEG-20 stearate, PEG-35 castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-7 hydrogenated castor oil, PEG-75 lanolin, poloxamer, sodium laureth sulfate, sodium trideceth sulfate, sodium C12-15 pareth 15 sulfonate, sodium C14-16 olefin sulfonate, or any combination thereof. 
     
     
         70 . The eyelid wipe of  claim 41 , further comprising a drug delivery system. 
     
     
         71 . The eyelid wipe of  claim 41 , further comprising at least one additional agent selected from the group consisting of anti-inflammatory agents, anti-bacterial agents, decongestants, antistatic agents, preservatives, antioxidants, antimicrobial agents, chelating agents, emollients, emulsifying agents, buffering/neutralising agents, humectants, thickeners, viscosity controlling agents, antistatic agents, conditioning agents, and any combination thereof. 
     
     
         72 . The eyelid wipe of  claim 71 , comprising the viscosity controlling agent that is polyethylene glycol (PEG). 
     
     
         73 . The eyelid wipe of  claim 41 , further comprising a reflective layer or a conductive layer to direct cooling towards a surface of the eyelid wipe. 
     
     
         74 . The eyelid wipe of  claim 41 , further comprising an indicator which confirms to a user that the desired temperature is reached. 
     
     
         75 . The eyelid wipe of  claim 74 , wherein the indicator is a temperature sensitive color indicator configured to change from a first color to a second color when the desired temperature is reached. 
     
     
         76 . The eyelid wipe of  claim 75 , wherein the indicator is configured to undergo a reversible color change, such that when the eyelid wipe is no longer at the desired temperature or falls outside of a desired temperature range, the indicator reverts to the first color. 
     
     
         77 . The eyelid wipe of  claim 74 , wherein at least a part of the eyelid wipe is coated with a temperature reactive ink or a temperature reactive dye.