Boron-containing small molecules

Abstract

This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

What is claimed is: 
     
         1 . A pharmaceutical formulation comprising:
 a) a pharmaceutically acceptable excipient; and   b) a compound, or a pharmaceutically acceptable salt thereof, having a structure according the following formula:   
       
         
           
           
               
               
           
         
       
       wherein
 R 7b  is a member selected from H, methyl, ethyl and phenyl; 
 R 10b  is a member selected from H, OH, NH 2 , SH, halogen, substituted phenoxy, substituted or unsubstituted phenylalkyloxy, substituted or unsubstituted phenylthio and substituted or unsubstituted phenylalkylthio; and 
 R 11b  is a member selected from H, OH, NH 2 , SH, methyl, substituted or unsubstituted phenoxy, substituted or unsubstituted phenylalkyloxy, substituted or unsubstituted phenylthio and substituted or unsubstituted phenylalkylthio.