Fullerene and its use to maintain good health and to prolong the expected lifespan of mammals

Abstract

A water-insoluble fullerene is at least partially dissolved in a biocompatible lipid carrier, especially a fat or an oil such as butter, olive oil, and liquid paraffin. When administered to mammals, the fullerene, most preferably [60]fullerene dissolved in olive oil, scavenges free radicals and prolongs life span in rats.

1 . A stable biocompatible composition comprising: (a) a carrier selected from the group consisting of fats and oils; and (b) one compound selected from the group consisting of water-insoluble fullerenes, wherein said fullerenes are mostly dissolved in said earner. 
     
     
         2 . The stable biocompatible composition of  claim 1 , wherein the carrier is selected from the group consisting of butter, cocoa butter, peanut butter, olive oil, soybean oil, cod-liver oil, liquid paraffin, and mixtures thereof. 
     
     
         3 . The stable biocompatible composition of  claim 1 , wherein said water-insoluble fullerenes are present in an amount ranging from 0.01 to 0.12% by weight relative to the total weight of the composition, preferably from 0.01 to 0.0.08% by weight. 
     
     
         4 . The stable biocompatible composition of  claim 1 , wherein the fullerene core of said water-insoluble fullerenes is Ceo. 
     
     
         5 . The stable biocompatible composition of  claim 1 , wherein said at least one water-insoluble fullerene is comprised in a therapeutically effective amount. 
     
     
         6 . The stable biocompatible composition of  claim 5 , wherein said at least one water-insoluble fullerene can eliminate biologically reactive radical species. 
     
     
         7 . The stable biocompatible composition of  claim 6 , wherein the biologically reactive radical species are initially generated from O2 or H2O2. 
     
     
         8 . A method to maintain good health and/or to prolong the expected lifespan of a mammal, which comprises a step of administering to said mammal a stable biocompatible composition according to any  claim 1 , wherein said composition is administered intravenously, intramuscularly, subcutaneously, intradermally, intrathecal̂, intraperitoneally, rectally by suppositories, sublingually, orally, or by inhalation. 
     
     
         9 . The method of  claim 8 , wherein said composition is administered in a pure form or in the form of an emulsion in water. 
     
     
         10 . The method of  claim 8 , wherein the at least one water-insoluble fullerene is administered in an amount of at least 0.1 mg/kg of body weight per day. 
     
     
         11 . The method of  claim 8 , wherein said mammal is a human. 
     
     
         12 . The method of  claim 8 , wherein it maintains the health and prolong the longevity of said mammal. 
     
     
         13 . A method to preserve a substance or mixture of substances sensitive to damages caused by free radicals, which comprises a step of adding to said substance or mixture of substances a stable composition according to  claim 1 . 
     
     
         14 . The method of  claim 12 , wherein said substance or mixture of substances is food or a nutritional composition.