Oxo-substituted imidazo[1,2b]pyridazines, their preparation and use as pharmaceuticals

Abstract

The invention relates to novel inhibitors of kinases of the general formula (I): in which Q and R 1 are defined in the claims, method for preparing such inhibitors, intermediates for preparing such inhibitors and uses of such inhibitors.

1 . A method for the treatment of a disease or disorder selected from inflammatory disorders, oncological disorders, and autoimmune disorders, or for producing immunosupression in a host in need thereof, comprising administering thereto an effective amount of a compound of the formula (I), 
       
         
           
           
               
               
           
         
         in which 
       
       Q is an aryl or heteroaryl radical linked through a carbon atom thereof to the imidazo[1,2b]pyridazine residue and which may optionally be substituted independently of one another by 1-3
 hydroxy groups, halogen atoms, nitro groups or cyano groups, 
 C 1 -C 6 -alkyl or C 3 -C 8 -cycloalkyl groups which may optionally be substituted by 1-3 hydroxy, halogen, cyano, (C 1 -C 5 )-alkoxy, COOR 6 , NHR 6 , NHCOR 6 , or N(R 2 ) 2  groups, 
 C 1 -C 6 -fluoroalkyl groups which may optionally be substituted by 1-3 hydroxy, optionally fluorinated (C 1 -C 5 )-alkoxy, or COOR 2  groups, 
 pyrrolidinyl groups, 
 (CH 2 ) u —SO 2 —R 2  groups in which u is 1, 2 or 3, 
 R 2  groups or O—CO—R 6  groups, 
 CO—O—R 6  groups, 
 CO—N(R 6 ) 2  groups, 
 NH—CO—R 6  groups, 
 CONR 7 R 8  groups, 
 (CH 2 ) n —NR 7 R 8  groups, 
 NH—CONHR 6  groups, 
 OR 6  groups, 
 SO 2 —R 2  groups, 
 SO 2 —OR 2  groups, 
 SO 2 —N(R 2 ) 2  groups, 
 NHSO 2 R 2  groups, 
 or 
 SR 2  groups, 
 in which R 2  is in each case independently of one another
 a hydrogen atom, a phenyl radical, an optionally partly or completely fluorinated C 1 -C 5 -alkyl radical or 
 a C 1 -C 5 -alkyl radical which is in turn optionally substituted 1-5 times by hydroxy radicals, cyano groups, phenyl groups, C 3 -C 7 -cycloalkyl radicals, SO 2 (C 1 -C 3 -alkyl) radicals, NH(C 1 -C 3 -alkyl) radicals, N[(C 1 -C 3 -alkyl)] 2  radicals, and/or C 1 -C 5 -alkoxy radicals, 
 or a C 3 -C 7 -cycloalkyl radical, 
 
 in which R 6  is in each case independently of one another 
 either
 a radical R 2 , 
 an aryl or heteroaryl radical which may in turn optionally be substituted independently of one another 1-3 times by hydroxy radicals, halogen atoms, cyano groups or C 1 -C 5 -alkoxy radicals, 
 a radical —(CH 2 ) u -Q s  in which u is 1, 2 or 3, and in which Q s  is an aryl or heteroaryl radical which may in turn optionally be substituted independently of one another 1-3 times by hydroxy radicals, halogen atoms, cyano groups or C 1 -C 5 -alkoxy radicals, 
 
 
       and in which R 1  is a
 3-dimethylaminopropyl, 
 3-diethylaminopropyl, 
 3-piperidin-1-ylpropyl, 
 2-dimethylaminoethyl, 
 2-diethylaminoethyl, 
 1-methylpiperidin-3-ylmethyl, 
 1-methylpyrrolidin-2-ylethyl, 
 4-diethylamino-1-methylbutyl, or 
 3-(4-methyl)piperazin-1-ylpropyl radical, 
 
       or a stereoisomer, or a salt or salt of the stereoisomer thereof with physiologically tolerated counterions. 
     
     
         2 . A method for the treatment of a disease or disorder selected from inflammatory disorders, oncological disorders, and autoimmune disorders, or for producing immunosupression in a host in need thereof, comprising administering thereto an effective amount of a compound of Formula I 
       
         
           
           
               
               
           
         
       
       in which Q is phenyl, biphenyl, naphthyl, tetralinyl, anthranyl, indanyl, indenyl, pyrazinyl, pyrimidinyl, pyridazinyl, triazinyl, azaindolizinyl, furanyl, oxazolyl, thiazolyl, furazanyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, tetrazolyl, thiadiazolyl, phthalidyl, thiophthalidyl, benzothiophenyl, indolyl, isoindolyl, indazolyl, benzothiazolyl, indolonyl, isoindolonyl, benzofuranyl, benzimidazolyl, benzoxazinonyl, phthalazinonyl, quinolinyl, isoquinolinyl, quinolonyl, isoquinolonyl, quinazolinyl, quinoxalinyl, cinnolinyl, phthalazinyl, 1,7- or 1,8-naphthyridinyl, coumarinyl, isocoumarinyl, indolizinyl, isobenzofuranyl, azaindolyl, azaisoindolyl, furanopyridyl, furanopyrimidinyl, furanopyrazinyl, furanopyidazinyl, chromenyl, isochromenyl, chromenonyl, isochromenonyl group, 4-aminopyridyl, chromanyl, isochromanyl, thiochromanyl, 
       in which Q may optionally be substituted independently of one another by 1-3
 hydroxy groups, halogen atoms, nitro groups or cyano groups, 
 C 1 -C 6 -alkyl or C 3 -C 5 -cycloalkyl groups which may optionally be substituted by 1-3 hydroxy, halogen, cyano, (C 1 -C 5 )-alkoxy, COOR 6 , NHR 6 , NHCOR 6 , or N(R 2 ) 2  groups, 
 C 1 -C 6 -fluoroalkyl groups which may optionally be substituted by 1-3 hydroxy, optionally fluorinated (C 1 -C 5 )-alkoxy, or COOR 2  groups, 
 pyrrolidinyl groups, 
 (CH 2 ) u —SO 2 —R 2  groups in which u is 1, 2 or 3, 
 R 2  groups or O—CO—R 6  groups, 
 CO—O—R 6  groups, 
 CO—N(R 6 ) 2  groups, 
 NH—CO—R 6  groups, 
 CONR 7 R 8  groups, 
 (CH 2 ) n —NR 7 R 8  groups, 
 NH—CONHR 6  groups, 
 OR 6  groups, 
 SO 2 —R 2  groups, 
 SO 2 —OR 2  groups, 
 SO 2 —N(R 2 ) 2  groups, 
 NHSO 2 R 2  groups, 
 or 
 SR 2  groups, 
 in which R 2  is in each case independently of one another
 a hydrogen atom, a phenyl radical, an optionally partly or completely fluorinated C 1 -C 5 -alkyl radical or 
 a C 1 -C 5 -alkyl radical which is in turn optionally substituted 1-5 times by hydroxy radicals, cyano groups, phenyl groups, C 3 -C 7 -cycloalkyl radicals, SO 2 (C 1 -C 3 -alkyl) radicals, NH(C 1 -C 3 -alkyl) radicals, N[(C 1 -C 3 -alkyl)] 2  radicals, and/or C 1 -C 5 -alkoxy radicals, 
 or a C 3 -C 7 -cycloalkyl radical, 
 
 in which R 6  is in each case independently of one another 
 either
 a radical R 2 , 
 an aryl or heteroaryl radical which may in turn optionally be substituted independently of one another 1-3 times by hydroxy radicals, halogen atoms, cyano groups or C 1 -C 5 -alkoxy radicals, 
 
 
       a radical —(CH 2 ) u -Q s  in which u is 1, 2 or 3, and in which Q s  is an aryl or heteroaryl radical which may in turn optionally be substituted independently of one another 1-3 times by hydroxy radicals, halogen atoms, cyano groups or C 1 -C 5 -alkoxy radicals, 
       and in which R 1  is
 a C 1 -C 6 -alkyl radical which may be substituted 1-3 times by —R 2 , —NR 3 R 4 , —NR 7 R 8  or —OR 2 , 
 a C 2 -C 6 -alkenyl radical which may be substituted 1-3 times by —R 2 , —NR 3 R 4 , —NR 7 R 8  or —OR 2 , 
 a C 2 -C 6 -alkynyl radical which may be substituted 1-3 times by —R 2 , —NR 3 R 4 , —NR 7 R 8  or —OR 2 , 
 a —(CH 2 ) n —NR 3 R 4  radical where n is a number 2-6 and in which R 3  and R 4  are independently of one another a hydrogen atom, a —COR 6  radical, a —SO 2 R 2  radical, or a C 1 -C 5 -alkyl radical which is in turn optionally substituted 1-3 times by a halogen atom, a hydroxy group, a cyano group, a nitro group, a group —R 2 , a group —NHR 2 , a group —N(R 2 ) 2 , a group —CO 2 R 6 , a group —OCOR 6 , a group —SO 2 R 2  or a group —OR 2 , 
 a —(CH 2 ) t —Z—(CH 2 ) m —NR 3 R 4  radical,
 where Z is a group —O—, —S—, —NR 2 —, —CHR 5 — or —C(R 5 ) 2 —, 
 m is a number 0, 1 or 2, t is a number 0, 1, 2 or 3, 
 and in which R 5  is a C 1 -C 3 -alkyl, C 2 -C 3 -alkenyl, C 2 -C 3 -alkynyl, a phenyl or a C 3 -C 6 -cycloalkyl radical, 
 
 a —(CH 2 ) n′ —NR 7 R 8  radical where n′ is a number 1-6 and in which R 7  and R 8  together form a 3-7-membered ring, where the 3-7-membered ring may comprise a further heteroatom, and where the 3-7-membered ring is optionally substituted 1-3 times by a halogen atom, a hydroxy group, a cyano group, a nitro group, a group —R 6 , a group —NHR 2 , a group —N(R 2 ) 2 , a group —CO 2 R 6 , a group —OCOR 6 , a group —SO 2 R 2  or a group —OR 2 , 
 a —(CH 2 ) n —(CH)R 7 R 8  radical, 
 a —(CH 2 ) t —Z—(CH 2 ) m —NR 7 R 8  radical, 
 a —(CH 2 ) t —Z—(CH 2 ) m —(CH)R 7 R 8  radical, 
 a —(CH 2 ) r —Y 1  radical where r is a number 0-3, and Y 1  is a piperidinyl or pyrrolidinyl ring, where the piperidinyl or pyrrolidinyl ring is optionally substituted 1-3 times independently of one another by a halogen atom, a hydroxy group, a cyano group, a nitro group, a group —R 6 , a group —NHR 2 , a group —N(R 2 ) 2 , a group —CO 2 R 6 , a group —OCOR 6 , a group —SO 2 R 2  or a group —OR 2 , 
 a —(CH 2 ) t —Z—(CH 2 ) m —Y 1  radical, 
 a —(CH 2 ) r —Y 2  radical where r is a number 0-3, and Y 2  is a morpholinyl ring, where the morpholinyl ring is optionally substituted 1-3 times by a halogen atom, a hydroxy group, a cyano group, a nitro group, a group —R 6 , a group —NHR 2 , a group —N(R 2 ) 2 , a group —CO 2 R 6 , a group —OCOR 6 , a group —SO 2 R 2  or a group —OR 2 , 
 a —(CH 2 ) t —Z—(CH 2 ) m —Y 2  radical, 
 a —(CH 2 ) r —Y 3  radical where r is a number 0-3, and Y 3  is a piperazinyl ring which optionally has a C 1 -C 3 -alkyl or a C 1 -C 3 -acyl group on the nitrogen atom, where the piperazinyl ring is optionally substituted 1-3 times by a halogen atom, a hydroxy group, a cyano group, a nitro group, a group —R 6 , a group —NHR 2 , a group —N(R 2 ) 2 , a group —CO 2 R 6 , a group —OCOR 6 , a group —SO 2 R 2  or a group —OR 2 , 
 a —(CH 2 ) t —Z—(CH 2 ) m —Y 3  radical, 
 a —(CH 2 ) r —Y 4  radical where r is a number 0-3, and Y 4  is a C 3 -C 8 -cycloalkyl ring which is optionally substituted 1-3 times by a halogen atom, a hydroxy group, a cyano group, a nitro group, a group —R 6 , a group —NHR 2 , a group —N(R 2 ) 2 , a group —CO 2 R 6 , a group —OCOR 6 , a group —SO 2 R 2  or a group —OR 2 , 
 a —(CH 2 ) t —Z—(CH 2 ) m —Y 4  radical, 
 a —(CH 2 ) r —Y 5  radical where r is a number 0-3, and Y 5  is an aryl or heteroaryl ring which is optionally substituted 1-3 times by a halogen atom, a hydroxy group, a cyano group, a nitro group, a group R 6 , a group —NHR 2 , a group —N(R 2 ) 2 , a group —CO 2 R 6 , a group —OCOR 6 , a group —SO 2 R 2 , a group —SO 2 N(R 2 ) 2 , a group —NHSO 2 R 2 , a group —NHCOR 6 , a group —NHCONHR 6  or a group —OR 2 , 
 
       a —(CH 2 ) t —Z—(CH 2 ) m —Y 5  radical, 
       R 2  is in each case independently of one another
 a hydrogen atom, a phenyl radical, an optionally partly or completely fluorinated C 1 -C 5 -alkyl radical or 
 a C 1 -C 5 -alkyl radical which is in turn optionally substituted 1-5 times by hydroxy radicals, cyano groups, phenyl groups, C 3 -C 7 -cycloalkyl radicals, SO 2 (C 1 -C 3 -alkyl) radicals, NH(C 1 -C 3 -alkyl) radicals, N[(C 1 -C 3 -alkyl)] 2  radicals, and/or C 1 -C 5 -alkoxy radicals, 
 or a C 3 -C 7 -cycloalkyl radical, 
 in which R 6  is in each case independently of one another 
 either
 a radical R 2 , 
 an aryl or heteroaryl radical which may in turn optionally be substituted independently of one another 1-3 times by hydroxy radicals, halogen atoms, cyano groups and/or C 1 -C 5 -alkoxy radicals, 
 a radical —(CH 2 ) u -Q s  in which u is the numbers 1, 2 or 3, and in which Q s  is an aryl or heteroaryl radical which may in turn optionally be substituted independently of one another 1-3 times by hydroxy radicals, halogen atoms, cyano groups and/or C 1 -C 5 -alkoxy radicals, 
 
 
       or a stereoisomer, or a salt or salt of the stereoisomer thereof with physiologically tolerated counterions. 
     
     
         3 . The method as claimed in  claim 2 , in which R 1  is a —(CH 2 ) n —NR 3 R 4  radical where n is 3 or 4, and in which R 3  and R 4  are independently of one another a C 1 -C 3  alkyl radical. 
     
     
         4 . The method as claimed in  claim 2 , in which R 1  is a —(CH 2 ) n —NR 7 R 8  radical where n is 3 or 4, and in which R 7  and R 8  together form a 5-7-membered ring. 
     
     
         5 . The method as claimed in  claim 2 , in which Q is an optionally substituted phenyl, biphenyl, furanyl, benzofuranyl, indolyl, benzothiophenyl or naphthyl radical. 
     
     
         6 . The method as claimed in  claim 5 , in which the aryl or heteroaryl radical present in Q is substituted by at least one of the following radicals: cyclopropylmethoxy-, fluoro, chloro, hydroxy-, cyano-, trifluoromethyl-, trifluoromethoxy-, methyl-, methoxy-, pyrrolidinyl-, —CO—OCH 3 , —CO 2 H, —CO—NH 2 , —CH 2 —CN, —CH 2 —OH, —S—CH 3 , —SO 2 —CH 2 CH 3 , or —NHCOCH 3 . 
     
     
         7 . A method for the treatment of a disease or disorder selected from inflammatory disorders, oncological disorders, and autoimmune disorders, or for producing immunosupression in a host in need thereof, comprising administering thereto an effective amount of a compound selected from: 
       6-[3-(4-methylpiperazin-1-yl)propoxy]-3-thiophen-3-ylimidazo[1,2-b]pyridazine; 3-(2,4-dichlorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-m-tolylimidazo[1,2b]pyridazine; 3-(3-chlorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(4-fluorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-phenylimidazo[1,2-b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(4-methylsulfanylphenyl)imidazo[1,2b]pyridazine; 3-(4-chlorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 1-(3-{6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(2-methylsulfanylphenyl)imidazo[1,2b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-biphenyl-3-yl-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; (3-{6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazin-3-yl}phenyl)methanol; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 3-(2-chlorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(4-trifluoromethoxyphenyl)imidazo[1,2b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(5-methylfuran-2-yl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(3-fluoro-4-methoxyphenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-o-tolylimidazo[1,2b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(5-chlorothiophen-2-yl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-{6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazin-3-yl}benzonitrile; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(4-methylthiophen-2-yl)imidazo[1,2b]pyridazine; (4-{6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazin-3-yl}phenyl)acetonitrile; 3-{6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2b]pyridazin-3-yl}benzoic acid methyl ester; 3-(1H-indol-4-yl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-benzofuran-2-yl-6-[3(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-p-tolylimidazo[1,2-b]pyridazine; 3-(3-fluorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-3-yl-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2b]pyridazine; 3-(4-chlorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(6-fluoro-5-methylpyridin-3-yl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(2-chloro-6-methylpyridin-3-yl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(2-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-(4-ethanesulfonylphenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2b]pyridazine; 3-(4-cyclopropylmethoxyphenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; diethyl-[4-(3-thiophen-3-ylimidazo[1,2b]pyridazin-6-yloxy)pentyl]amine; {4-[3-(2,4-dichlorophenyl)imidazo[1,2b]pyridazin-6-yloxy]pentyl}diethylamine; diethyl-[4-(3-m-tolylimidazo[1,2b]pyridazin-6-yloxy)pentyl]amine; {4-[3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; [4-(3-benzo[b]thiophen-2-ylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]diethylamine; diethyl-{4-[3-(4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; {4-[3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; 1-{3-[6-(4-diethylamino-1-methylbutoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone; diethyl-{4-[3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; [4-(3-biphenyl-3-ylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]diethylamine; {3-[6-(4-diethylamino-1-methylbutoxy)imidazo[1,2b]pyridazin-3-yl]phenyl}methanol; diethyl-{4-[3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(4-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; {4-[3-(3-chloro-4-methylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; diethyl-{4-[3-(5-methylfuran-2-yl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(3-fluoro-4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-[4-(3-o-tolylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]amine; {4-[3-(3-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; {4-[3-(5-chlorothiophen-2-yl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; 3-[6-(4-diethylamino-1-methylbutoxy)imidazo[1,2b]pyridazin-3-yl]benzonitrile; diethyl-{4-[3-(4-methylthiophen-2-yl)imidazo[1,2b]pyridazin-6-yloxy]pentyl}amine; {4-[6-(4-diethylamino-1 methylbutoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetonitrile; 3-[6-(4-diethylamino-1-methylbutoxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; diethyl-{4-[3-(1H-indol-4-yl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; [4-(3-benzofuran-2-ylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]diethylamine; diethyl-[4-(3-p-tolylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]amine; diethyl-{4-[3-(3-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; [4-(3-benzo[b]thiophen-3-ylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]diethylamine; {4-[3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; diethyl-{4-[3-(6-fluoro-5-methylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(2-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; {5-[6-(4-diethylamino-1-methylbutoxy)imidazo[1,2-b]pyridazin-3-yl]thiophen-2-yl}methanol; {4-[3-(4-cyclopropylmethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-thiophen-3-ylimidazo[1,2-b]pyridazine; 3-(2,4-dichlorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-m-tolylimidazo[1,2-b]pyridazine; 3-(3-chlorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-(4-fluorophenyl)-6-[2-(1 methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-phenylimidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(4-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 1(3-{6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-biphenyl-3-yl-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; (3-{6-[2-(1 methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazin-3-yl}phenyl)methanol; 6[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(3-methylsulfanylphenyl)imidazo[1,2b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-(2-chlorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(4-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-(3-fluoro-4-methoxyphenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-o-tolylimidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2b]pyridazine; 3-{6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazin-3-yl}benzonitrile; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(4-methylthiophen-2-yl)imidazo[1,2-b]pyridazine; (4-{6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazin-3-yl}phenyl)acetonitrile; 3-{6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazin-3-yl}benzoic acid methyl ester; 3-(1H-indol-4-yl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2b]pyridazine; 3-(2-fluoropyridin-3-yl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-benzofuran-2-yl-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-ptolylimidazo[1,2-b]pyridazine; 3-(3-fluorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-3-yl-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6-[2(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-(6-fluoro-5-methylpyridin-3-yl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2b]pyridazine; 3-(2-chloro-6-methylpyridin-3-yl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(2-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-(4-ethanesulfonylphenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6-[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2-b]pyridazine; 3(4-cyclopropylmethoxyphenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-ylmethoxy)-3-thiophen-3-ylimidazo[1,2-b]pyridazine; 3-(2,4-dichlorophenyl)-6-(1 methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-(3-chlorophenyl)-6-(1 methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-(4-fluorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-ylmethoxy)-3-phenylimidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-ylmethoxy)-3-(4-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 3(4-chlorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 1{3-[6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone; 6-(1-methylpiperidin-3-ylmethoxy)-3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-ylmethoxy)-3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-biphenyl-3-yl-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; {3-[6-(1 methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}methanol; 6(1-methylpiperidin-3-ylmethoxy)-3-(3-methylsulfanylphenyl)imidazo[1,2b]pyridazine; 6-(1-methylpiperidin-3-ylmethoxy)-3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-(2-chlorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-ylmethoxy)-3-(4-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-(5-methylfuran-2-yl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-(3-fluoro-4-methoxyphenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 6(1-methylpiperidin-3-ylmethoxy)-3-o-tolylimidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3(5-chlorothiophen-2-yl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2b]pyridazine; 3-[6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; 6-(1-methylpiperidin-3-ylmethoxy)-3-(4-methylthiophen-2-yl)imidazo[1,2-b]pyridazine; {4-[6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2b]pyridazin-3-yl]phenyl}acetonitrile; 3-[6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; 3-(1H-indol-4-yl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-(2-fluoropyridin-3-yl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-benzofuran-2-yl-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 6(1-methylpiperidin-3-ylmethoxy)-3-p-tolylimidazo[1,2-b]pyridazine; 3-(3-fluorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-3-yl-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2b]pyridazine; 3-(4-chlorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2b]pyridazine; 3-(6-fluoro-5-methylpyridin-3-yl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-ylmethoxy)-3-(2-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-(4-ethanesulfonylphenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 6-(1 methylpiperidin-3-ylmethoxy)-3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2b]pyridazine; 3-(4-cyclopropylmethoxyphenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; diethyl-[3-(3-thiophen-3-ylimidazo[1,2b]pyridazin-6-yloxy)propyl]amine; diethyl-[3-(3-naphthalen-1-ylimidazo[1,2-b]pyridazin-6-yloxy)propyl]amine; diethyl-{3-[3-(4-methoxyphenyl)imidazo[1,2b]pyridazin-6-yloxy]propyl}amine; diethyl-[3-(3-m-tolylimidazo[1,2-b]pyridazin-6-yloxy)propyl]amine; {3-[3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; [3-(3-benzo[b]thiophen-2-ylimidazo[1,2-b]pyridazin-6-yloxy)propyl]diethylamine; diethyl-{3-[3-(4-fluorophenyl)imidazo[1,2b]pyridazin-6-yloxy]propyl}amine; diethyl-[3-(3-phenylimidazo[1,2-b]pyridazin-6-yloxy)propyl]amine; diethyl-{3-[3-(4-methylsulfanylphenyl)imidazo[1,2b]pyridazin-6-yloxy]propyl}amine; {3-[3-(4-chlorophenyl)imidazo[1,2b]pyridazin-6-yloxy]propyl}diethylamine; 1-{3-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone; diethyl-{3-[3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl-{3-[3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl-{3-[3-(3-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; [3(3-biphenyl-3-ylimidazo[1,2-b]pyridazin-6-yloxy)propyl]diethylamine; {3-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}methanol; diethyl-{3[3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl-{3-[3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {3-[3-(2-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; diethyl-{3-[3-(4-trifluoromethoxyphenyl)imidazo[1,2b]pyridazin-6-yloxy]propyl}amine; diethyl-{3-[3-(4-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {3-[3-(3-chloro-4-methylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; diethyl-{3-[3-(5-methylfuran-2-yl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl-{3-[3-(3-fluoro-4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl[3-(3-o-tolylimidazo[1,2-b]pyridazin-6-yloxy)propyl]amine; {3-[3-(3-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; diethyl-{3-[3(3-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {3-[3-(5-chlorothiophen-2-yl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; 3-[6(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; diethyl-{3-[3(4-methylthiophen-2-yl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {4-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetonitrile; 3-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; N-{3-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetamide; diethyl-{3-[3-(1H-indol-4-yl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; [3-(3-benzofuran-2-ylimidazo[1,2-b]pyridazin-6-yloxy)propyl]diethylamine; diethyl-[3-(3-p-tolylimidazo[1,2-b]pyridazin-6-yloxy)propyl]amine; diethyl-{3-[3-(3-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; [3-(3-benzo[b]thiophen-3-ylimidazo[1,2-b]pyridazin-6-yloxy)propyl]diethylamine; {3-[3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; diethyl-{3-[3-(6-fluoro-5-methylpyridin-3-yl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl-{3-[3-(2-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {3-[3-(4-ethanesulfonylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethyl-amine; diethyl-{3-[3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {3-[3-(4-cyclopropylmethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; 6-(1-methylpiperidin-3-yloxy)-3-thiophen-3-ylimidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-naphthalen-1-ylimidazo[1,2-b]pyridazine; 3-(4-methoxyphenyl)-6-(1 methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-(2,4-dichlorophenyl)-6-(1 methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-m-tolylimidazo[1,2-b]pyridazine; 3-(3-chlorophenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-(4-fluorophenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 6-(1 methylpiperidin-3-yloxy)-3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-(3-trifluoromethylphenyl)imidazo[1,2b]pyridazine; 3-biphenyl-3-yl-6-(1-methylpiperidin-3-yloxy)imidazo[1,2b]pyridazine; {3-[6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}methanol; 6-(1-methylpiperidin-3-yloxy)-3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-(2-chlorophenyl)-6-(1 methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-(4-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-(4-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2b]pyridazine; 3-(5-methylfuran-2-yl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2b]pyridazine; 3-(3-fluoro-4-methoxyphenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-O— tolylimidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-(3-methoxyphenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-(5-chlorothiophen-2-yl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-[6-(1-methylpiperidin-3-yloxy)imidazo[1,2b]pyridazin-3-yl]benzonitrile; 6-(1-methylpiperidin-3-yloxy)-3-(4-methylthiophen-2-yl)imidazo[1,2-b]pyridazine; {4-[6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetonitrile; 3-[6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; N-{3-[6-(1 methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetamide; 3-(1H-indol-4-yl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-benzofuran-2-yl-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1 methylpiperidin-3-yloxy)-3-p-tolylimidazo[1,2-b]pyridazine; 3-(3-fluorophenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-3-yl-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-(6-fluoro-5-methylpyridin-3-yl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1 methylpiperidin-3-yloxy)-3-(2-trifluoromethoxyphenyl)imidazo; [1,2b]pyridazine; 3-(4-ethanesulfonylphenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-methylpiperidin-3-yloxy)-3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2-b]pyridazine; 3-(4-cyclopropylmethoxyphenyl)-6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-thiophen-3-ylimidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-naphthalen-1-ylimidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-(4-methoxyphenyl)imidazo[1,2-b]pyridazine; 3-(2,4-dichlorophenyl)-6-(1 ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-(3-chlorophenyl)-6-(1 ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3(4-fluorophenyl)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-phenylimidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-(4-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6-(1 ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 1-{3-[6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone; 6-(1-ethylpyrrolidin-3-yloxy)-3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-(3-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-biphenyl-3-yl-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; {3-[6-(1 ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}methanol; 6-(1 ethylpyrrolidin-3-yloxy)-3-(3-methylsulfanyl phenyl)imidazo[1,2-b]pyridazine; 6(1-ethylpyrrolidin-3-yloxy)-3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-(2-chlorophenyl)-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1 ethylpyrrolidin-3-yloxy)-3-(4-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-(4-trifluoromethylphenyl)imidazo[1,2b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3(3-methoxyphenyl)imidazo[1,2-b]pyridazine; 3-(5-chlorothiophen-2-yl)-6-(1 ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 3-[6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; 6-(1-ethylpyrrolidin-3-yloxy)-3(4-methylthiophen-2-yl)imidazo[1,2-b]pyridazine; 3-[6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; N-{3-[6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetamide; 6-(1-ethylpyrrolidin-3-yloxy)-3-(1H-indol-4-yl)imidazo[1,2-b]pyridazine; 3-benzofuran-2-yl-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-p-tolylimidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-(3-fluorophenyl)imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6-(1 ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3(6-fluoro-5-methylpyridin-3-yl)imidazo[1,2-b]pyridazine; 6-(1-ethylpyrrolidin-3-yloxy)-3-(2-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-(4-ethanesulfonylphenyl)-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 6(1-ethylpyrrolidin-3-yloxy)-3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2-b]pyridazine; 3-(4-cyclopropylmethoxyphenyl)-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-thiophen-3-ylimidazo[1,2b]pyridazine; 3-naphthalen-1-yl-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(4-methoxyphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-m-tolylimidazo[1,2-b]pyridazine; 3(3-chlorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3(4-fluorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-phenyl-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(4-methylsulfanylphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3(4-chlorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 1-{3-[6(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone; 3-(2-methylsulfanylphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 6(3-piperidin-1-ylpropoxy)-3-(3-trifluoromethoxyphenyl)imidazo[1,2b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-(3-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-biphenyl-3-yl-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; {3-[6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}methanol; 3-(3-methylsulfanylphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-(2-chlorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3(4-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-(4-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(5-methylfuran-2-yl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(3-fluoro-4-methoxyphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-o-tolylimidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(3-methoxyphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(5-chlorothiophen-2-yl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-[6(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; 3-[6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; {4-[6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetonitrile; 3-[6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; N-{3-[6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetamide; 3-(1H-indol-4-yl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2b]pyridazine; 3-benzofuran-2-yl-6-(3-piperidin-1-ylpropoxy)imidazo[1,2b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-p-tolylimidazo[1,2-b]pyridazine; 3(3-fluorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(6-fluoro-5-methylpyridin-3-yl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-(2-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3(4-ethanesulfonylphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2-b]pyridazine; 3-(4-cyclopropylmethoxyphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2b]pyridazine; dimethyl-[4-(3-thiophen-3-ylimidazo[1,2-b]pyridazin-6-yloxy)butyl]amine; dimethyl-[4-(3-naphthalen-1-ylimidazo[1,2-b]pyridazin-6-yloxy)butyl]amine; {4-[3-(4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}dimethylamine; dimethyl-[4-(3-m-tolylimidazo[1,2-b]pyridazin-6-yloxy)butyl]amine; {4-[3-(4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}dimethylamine; dimethyl-[4-(3-phenylimidazo[1,2-b]pyridazin-6-yloxy)butyl]amine; dimethyl-{4-[3-(4-methylsulfanylphenyl)imidazo[1,2b]pyridazin-6-yloxy]butyl}amine; {4-[3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}dimethylamine; 1-{3-[6-(4-dimethylaminobutoxy)imidazo[1,2b]pyridazin-3-yl]phenyl}ethanone; dimethyl-{4-[3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; dimethyl-{4-[3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; dimethyl-{4-[3-(3-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; [4-(3-biphenyl-3-ylimidazo[1,2-b]pyridazin-6-yloxy)butyl]dimethylamine; {3-[6-(4-dimethylaminobutoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}methanol; dimethyl{4-[3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; dimethyl-{4-[3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; dimethyl-{4-[3-(4-trifluoromethoxyphenyl)imidazo[1,2b]pyridazin-6-yloxy]butyl}amine; dimethyl-{4-[3-(4-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; {4-[3-(3-fluoro-4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}dimethylamine; dimethyl-[4-(3-o-tolylimidazo[1,2-b]pyridazin-6-yloxy)butyl]amine; {4-[3-(3-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}dimethylamine; dimethyl{4-[3-(4-methylthiophen-2-yl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; {4[6-(4-dimethylaminobutoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetonitrile; 3[6-(4-dimethylaminobutoxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; N-{3-[6-(4-dimethylaminobutoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetamide; {4-[3-(1H-indol-4-yl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}dimethylamine; dimethyl-[4-(3-p-tolylimidazo[1,2-b]pyridazin-6-yloxy)butyl]amine; dimethyl-{4-[3-(2-trifluoromethoxyphenyl)imidazo[1,2b]pyridazin-6-yloxy]butyl}amine; dimethyl-{4-[3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; {4-[3-(4-cyclopropylmethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}dimethylamine; and 6-phenoxy-3-m-tolylimidazo[1,2b]pyridazine. 
     
     
         8 . The method as claimed in  claim 2 , in which Q is an optionally substituted phenyl, biphenyl, naphthyl, tetralinyl, benzothiophenyl, indolyl, indazolyl, benzothiazolyl, benzofuranyl, benzimidazolyl, benzoxazinonyl, isobenzofuranyl, azaindolyl, azaisoindolyl, furanopyridyl, furanopyrimidinyl, furanopyrazinyl, or furanopyidazinyl. 
     
     
         9 . The method as claimed in  claim 2 , in which Q is an optionally substituted phenyl, biphenyl, naphthyl, benzothiophenyl, indolyl, or benzofuranyl. 
     
     
         10 . The method as claimed in  claim 7 , wherein the compound is selected from: 3-(3-chlorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-biphenyl-3-yl-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(3-fluorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(2-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-(4-ethanesulfonylphenyl)-6-[3-(4-methylpiperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; 6-[3-(4-methylpiperazin-1-yl)propoxy]-3-(3-pyrrolidin-1-ylphenyl)imidazo[1,2b]pyridazine; 3-(4-cyclopropylmethoxyphenyl)-6-[3-(4-methyl piperazin-1-yl)propoxy]imidazo[1,2-b]pyridazine; diethyl-[4-(3-thiophen-3-ylimidazo[1,2b]pyridazin-6-yloxy)pentyl]amine; {4-[3-(2,4-dichlorophenyl)imidazo[1,2b]pyridazin-6-yloxy]pentyl}diethylamine; diethyl-[4-(3-m-tolylimidazo[1,2b]pyridazin-6-yloxy)pentyl]amine; {4-[3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; [4-(3-benzo[b]thiophen-2-ylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]diethylamine; diethyl-{4-[3-(4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; 1-{3-[6-(4-diethylamino-1-methylbutoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone; diethyl-{4-[3-(2-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; diethyl-{4-[3-(3-trifluoromethoxyphenyl)imidazo[1,2b]pyridazin-6-yloxy]pentyl}amine; [4-(3-biphenyl-3-ylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]diethylamine; {3-[6-(4-diethylamino-1-methylbutoxy)imidazo[1,2b]pyridazin-3-yl]phenyl}methanol; diethyl-{4-[3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; {4-[3-(3-chloro-4-methylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; diethyl-{4-[3-(3-fluoro-4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; {4-[3-(3-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; 3-[6-(4-diethylamino-1-methylbutoxy)imidazo[1,2b]pyridazin-3-yl]benzonitrile; diethyl-{4-[3-(1H-indol-4-yl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; [4-(3-benzofuran-2-ylimidazo[1,2-b]pyridazin-6-yloxy)pentyl]diethylamine; diethyl-{4-[3-(3-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}amine; {4-[3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]pentyl}diethylamine; 3-(3-chlorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 1(3-{6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone; 3-biphenyl-3-yl-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 6[2-(1-methylpyrrolidin-2-yl)ethoxy]-3-(3-methylsulfanylphenyl)imidazo[1,2b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-(3-fluoro-4-methoxyphenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2b]pyridazine; 3-{6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazin-3-yl}benzonitrile; 3-{6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazin-3-yl}benzoic acid methyl ester; 3-(3-fluorophenyl)-6-[2-(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6-[2(1-methylpyrrolidin-2-yl)ethoxy]imidazo[1,2-b]pyridazine; 3-(3-chlorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 1{3-[6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone; 6-(1-methylpiperidin-3-ylmethoxy)-3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazine; 3-biphenyl-3-yl-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 6(1-methylpiperidin-3-ylmethoxy)-3-(3-methylsulfanylphenyl)imidazo[1,2b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazine; 3-[6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; 3-[6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; 3-(4-chlorophenyl)-6-(1-methylpiperidin-3-ylmethoxy)imidazo[1,2b]pyridazine; diethyl-{3-[3-(4-methoxyphenyl)imidazo[1,2b]pyridazin-6-yloxy]propyl}amine; diethyl-[3-(3-m-tolylimidazo[1,2-b]pyridazin-6-yloxy)propyl]amine; {3-[3-(3-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; [3-(3-benzo[b]thiophen-2-ylimidazo[1,2-b]pyridazin-6-yloxy)propyl]diethylamine; diethyl-{3-[3-(4-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; 1-{3-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone; diethyl-{3-[3-(3-trifluoromethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl{3-[3-(3-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; [3(3-biphenyl-3-ylimidazo[1,2-b]pyridazin-6-yloxy)propyl]diethylamine; diethyl-{3[3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl-{3-[3-(2-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {3-[3-(2-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; diethyl-{3-[3-(4-trifluoromethoxyphenyl)imidazo[1,2b]pyridazin-6-yloxy]propyl}amine; diethyl-{3-[3-(4-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {3-[3-(3-chloro-4-methylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; diethyl-{3-[3-(3-fluoro-4-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; diethyl[3-(3-o-tolylimidazo[1,2-b]pyridazin-6-yloxy)propyl]amine; {3-[3-(3-chloro-4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; diethyl-{3-[3(3-methoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; 3-[6(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; {4-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetonitrile; 3-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; N-{3-[6-(3-diethylaminopropoxy)imidazo[1,2-b]pyridazin-3-yl]phenyl}acetamide; diethyl-{3-[3-(1H-indol-4-yl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; [3-(3-benzofuran-2-ylimidazo[1,2-b]pyridazin-6-yloxy)propyl]diethylamine; diethyl-{3-[3-(3-fluorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}amine; {3-[3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yloxy]propyl}diethylamine; {3-[3-(4-cyclopropylmethoxyphenyl)imidazo[1,2b]pyridazin-6-yloxy]propyl}diethylamine; 3-[6-(1-methylpiperidin-3-yloxy)imidazo[1,2-b]pyridazin-3-yl]benzoic acid methyl ester; 3-(4-chlorophenyl)-6-(1-ethylpyrrolidin-3-yloxy)imidazo[1,2-b]pyridazine; 3(3-chlorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-benzo[b]thiophen-2-yl-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 6-(3-piperidin-1-ylpropoxy)-3-(3-trifluoromethylphenyl)imidazo[1,2-b]pyridazine; 3-(3-methylsulfanylphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-methylphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(3-fluoro-4-methoxyphenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(3-chloro-4-fluorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-[6(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; 3-[6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazin-3-yl]benzonitrile; 3(3-fluorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; 3-(4-chlorophenyl)-6-(3-piperidin-1-ylpropoxy)imidazo[1,2-b]pyridazine; dimethyl-{4-[3-(3-trifluoromethylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; [4-(3-biphenyl-3-ylimidazo[1,2-b]pyridazin-6-yloxy)butyl]dimethylamine; dimethyl{4-[3-(3-methylsulfanylphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}amine; {4-[3-(4-cyclopropylmethoxyphenyl)imidazo[1,2-b]pyridazin-6-yloxy]butyl}dimethylamine; and 6-phenoxy-3-m-tolylimidazo[1,2b]pyridazine. 
     
     
         11 . The method as claimed in  claim 1 , in which Q is an optionally substituted phenyl, biphenyl, furanyl, benzofuranyl, indolyl, benzothiophenyl or naphthyl radical. 
     
     
         12 . The method as claimed in  claim 11 , in which the aryl or heteroaryl radical present in Q is substituted by at least one of the following radicals: cyclopropylmethoxy-, fluoro, chloro, hydroxy-, cyano-, trifluoromethyl-, trifluoromethoxy-, methyl-, methoxy-, pyrrolidinyl-, —CO—OCH 3 , —CO—CH 3 , —CO 2 H, —CO—NH 2 , —CH 2 —CN, —CH 2 —OH, —CH 2 —S—CH 3 , —S—CH 3 , —SO 2 —CH 2 CH 3 , or —NHCOCH 3 . 
     
     
         13 . The method as claimed in  claim 1 , in which Q is an optionally substituted phenyl, biphenyl, naphthyl, tetralinyl, benzothiophenyl, indolyl, indazolyl, benzothiazolyl, benzofuranyl, benzimidazolyl, benzoxazinonyl, isobenzofuranyl, azaindolyl, azaisoindolyl, furanopyridyl, furanopyrimidinyl, furanopyrazinyl, or furanopyidazinyl. 
     
     
         14 . The method as claimed in  claim 1 , in which Q is an optionally substituted phenyl, biphenyl, naphthyl, benzothiophenyl, indolyl, or benzofuranyl. 
     
     
         15 . The method as claimed in  claim 1 , wherein the disease or disorder is a solid tumor or metastesis thereof. 
     
     
         16 . The method as claimed in  claim 2 , wherein the disease or disorder is a solid tumor or metastesis thereof. 
     
     
         17 . The method as claimed in  claim 7 , wherein the disease or disorder is a solid tumor or metastesis thereof. 
     
     
         18 . The method as claimed in  claim 1 , wherein the disease or disorder is characterized by the dysregulation of a protein kinase. 
     
     
         19 . The method as claimed in  claim 2 , wherein the disease or disorder is characterized by the dysregulation of a protein kinase. 
     
     
         20 . The method as claimed in  claim 7 , wherein the disease or disorder is characterized by the dysregulation of a protein kinase.