Anti-obesity agent comprising compound containing benzotropolone ring

Abstract

The object of the present invention is to provide an anti-obesity agent which contains a tea-derived component and which is safe and does not compromise the flavor of foods and beverages. According to the present invention, a safe and palatable anti-obesity agent can be provided by incorporating a benzotropolone ring-containing compound which has tea-derived, high inhibitory activities against lipase and alfa-glucosidase. The anti-obesity agent of the present invention does not compromise the flavor of foods and beverage, has palatability, and can be used in various use applications including foods and beverages intended for health enhancement such as reduction in triglycerides.

1 . An anti-obesity agent comprising one or more compounds of Formula (1) (except epitheaflagallin, theaflavin, theaflavin-3-O-gallate, theaflavin-3′-O-gallate, and theaflavin-3,3′-O-digallate): 
       
         
           
           
               
               
           
         
         (wherein R 1  is H or OH; 
         R 2  is H or a group of Formula (2): 
       
       
         
           
           
               
               
           
         
         wherein R 4  is OH, a group of Formula (3): 
       
       
         
           
           
               
               
           
         
         or a group of Formula (4): 
       
       
         
           
           
               
               
           
         
         wherein R 3  is H, COOH, a group of Formula (5): 
       
       
         
           
           
               
               
           
         
         or a group of Formula (6): 
       
       
         
           
           
               
               
           
         
         wherein R 5  is OH, a group of Formula (7): 
       
       
         
           
           
               
               
           
         
         or a group of Formula (8): 
       
       
         
           
           
               
               
           
         
         wherein R 6  is a group of Formula (9): 
       
       
         
           
           
               
               
           
         
         or a group of Formula (10): 
       
       
         
           
           
               
               
           
         
         wherein R 1 ′ is the same group as R 1  above and R 2 ′ is a group of Formula (11): 
       
       
         
           
           
               
               
           
         
         wherein R 4 ′ is the same group as R above). 
       
     
     
         2 . The antiobesity agent according to  claim 1 , comprising one or more compounds in which R 1  is H. 
     
     
         3 . The anti-obesity agent according to  claim 1 , wherein the compound is a compound of Formula (12): 
       
         
           
           
               
               
           
         
         Formula (13): 
       
       
         
           
           
               
               
           
         
         Formula (14): 
       
       
         
           
           
               
               
           
         
         Formula (15): 
       
       
         
           
           
               
               
           
         
         Formula (16): 
       
       
         
           
           
               
               
           
         
         Formula (17): 
       
       
         
           
           
               
               
           
         
         Formula (18): 
       
       
         
           
           
               
               
           
         
         Formula (19): 
       
       
         
           
           
               
               
           
         
         Formula (20): 
       
       
         
           
           
               
               
           
         
         Formula (21): 
       
       
         
           
           
               
               
           
         
         Formula (22): 
       
       
         
           
           
               
               
           
         
         Formula (23): 
       
       
         
           
           
               
               
           
         
       
     
     
         4 . The anti-obesity agent according to  claim 1 , which is a lipase inhibitor and/or an alfa-glucosidase inhibitor. 
     
     
         5 . The anti-obesity agent according to  claim 1 , which is for suppressing absorption of diet-derived fat and sugar. 
     
     
         6 . The anti-obesity agent according to  claim 1 , which is in the form of a food or a beverage. 
     
     
         7 . The anti-obesity agent according to  claim 6 , wherein the food or beverage is selected from the group consisting of a tea beverage, a soft drink, and a health food. 
     
     
         8 . The anti-obesity agent according to  claim 1 , which is in the form of a pharmaceutical composition. 
     
     
         9 . A compound of Formula (24):