US2014120159A1PendingUtilityA1
Cyanide antidote compositions and methods of use
Est. expiryOct 30, 2032(~6.2 yrs left)· nominal 20-yr term from priority
A61K 31/105C07C 381/00C07C 317/14
43
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Claims
Abstract
Cyanide antidote compositions and methods of use are described herein. A cyanide antidote composition may include a sulfur analog, sulfur analog derivative, or a pharmaceutically acceptable derivative of a sulfur analog.
Claims
exact text as granted — not AI-modified1 . A cyanide antidote composition, comprising:
a sulfur analog, or pharmaceutically acceptable derivative of a sulfur analog, having the structure:
R 1 —S n —R 2 (I)
where R 1 is R 3 —SO 2 —; R 2 is R 4 —SO 2 ; and n is 1 to 8; where R 3 is an alkyl moiety or an aryl moiety; where R 4 is an alkyl moiety or an aryl moiety.
2 . The cyanide antidote of claim 1 , wherein the sulfur analog has the structure:
3 . The cyanide antidote of claim 2 , wherein R 3 and R 4 comprise aryl moieties and n is 1.
4 . The cyanide antidote of claim 2 , wherein R 3 and R 4 comprise one or more substituted aryl moieties.
5 . The cyanide antidote of claim 1 , wherein R 3 is an allyl moiety and R 4 is an aryl moiety.
6 . The cyanide antidote of claim 1 , wherein the sulfur analog has the structure:
where X and Y are alkyl, OH, NH 2 , NHCO 2 R 6 , and/or CO 2 R 6 , where R 6 is hydrogen, alkyl or aryl, or amino; and n ranges from 1 to 8, from 2 to 6, or from 3 to 5; and n is at least 3.
7 . The cyanide antidote of claim 1 , wherein the sulfur analog has the structure:
where X and Y are alkyl moieties and n is at least 3.
8 . The cyanide antidote of claim 1 , wherein the sulfur analog has the structure:
9 . The cyanide antidote of claim 1 , further comprising liposomes and/or dentrimeric polymers.
10 . The cyanide antidote of claim 1 , wherein the sulfur analog has the structure S n R 5 , where R 5 is an alkyl moiety, or aryl moiety and n is at least 3.
11 . The cyanide antidote of claim 1 , wherein the sulfur analog has the structure:
where X and Y are alkyl, OH, NH 2 , NHCO 2 R 6 , and/or CO 2 R 6 , where R 6 is hydrogen, alkyl or aryl, or amino; and n ranges from 1 to 8.
12 . A method of treating cyanide intoxication in a subject, comprising:
administrating to a subject who would benefit from such treatment a therapeutically effective amount of a sulfur analog, or pharmaceutically acceptable derivative of a sulfur analog in an amount sufficient to convert at least some cyanide to thiocyanate to detoxify the subject, wherein the sulfur analog has the structure
R 1 —S n —R 2 (I)
where R 1 is S or R 3 —SO 2 —; R 2 is R 4 —SO 2 — or R 5 ; and n is 1 to 8; where R 1 is R 3 —SO 2 —; R 2 is R 4 —SO 7 ; and n isl to 8; where R 3 is an alkyl moiety or an aryl moiety; where R 4 is an alkyl moiety or an aryl moiety.
13 . The method of claim 12 , wherein the sulfur analog has the structure:
14 . The method of claim 13 , wherein R 3 and R 4 comprise aryl moieties and n is 1.
15 . The method of claim 13 , wherein R 3 and R 4 comprise one or more substituted aryl moieties.
16 . The method of claim 12 , wherein R 3 is an allyl moiety and R 4 is an aryl moiety.
17 . The method of claim 12 , wherein the sulfur analog has the structure:
where X and Y are alkyl, OH, NH 2 , NHCO 2 R 6 , and/or CO 2 R 6 , where R 6 is hydrogen, alkyl or aryl, or amino; and n ranges from 1 to 8, from 2 to 6, or from 3 to 5; and n is at least 3.
18 . The method of claim 12 , wherein the sulfur analog has the structure:
where X and Y are alkyl moieties and n is at least 3.
19 . The method of claim 12 , wherein the sulfur analog has the structure:
20 . The method of claim 12 , further comprising liposomes and/or dentrimeric polymers.
21 . The method of claim 12 , wherein the sulfur analog has the structure S n R 5 , where R 5 is an alkyl moiety, or aryl moiety and n is at least 3.
22 . The method of claim 12 , wherein the sulfur analog has the structure:
where X and Y are alkyl, OH, NH 2 , NHCO 2 R 6 , and/or CO 2 R 6 , where R 6 is hydrogen, alkyl or aryl, or amino; and n ranges from 1 to 8.
23 - 27 . (canceled)
28 . A compound having the structure:
R 1 —S n —R 2 (I)
where R 1 is R 3 —SO 2 —; R 2 is R 4 —SO 7 ; and n is 1 to 8; where R 3 is an alkyl moiety or an aryl moiety; where R 4 is an alkyl moiety or an aryl moiety.
29 - 38 . (canceled)Join the waitlist — get patent alerts
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