Wound closure device

Abstract

Biocompatible wound closure devices including an elongate body and a plug member are useful for wound repair.

1 - 20 . (canceled) 
     
     
         21 . A wound closure device comprising:
 an elongate body having a proximal end and a distal end, the elongate body formed from a hydrogel and;   a plug member coupled to the distal end of the elongate body, the plug member fabricated from a porous material.   
     
     
         22 . The wound closure device of  claim 21 , wherein the elongate body includes a grooved exterior surface. 
     
     
         23 . The wound closure device of  claim 21 , wherein the elongate body has a length of about 10 mm to about 150 mm. 
     
     
         24 . The wound closure device of  claim 21 , wherein the hydrogel is bioabsorbable. 
     
     
         25 . The wound closure device of  claim 21 , wherein the hydrogel is formed from multiple precursors. 
     
     
         26 . The wound closure device of  claim 21 , wherein the hydrogel is formed from a single precursor. 
     
     
         27 . The wound closure device of  claim 21 , wherein the hydrogel is activated by an environmental condition selected from the group consisting of temperature, pressure, pH, ionic strength, and combinations thereof. 
     
     
         28 . The wound closure device of  claim 21 , wherein the plug member comprises a mesh. 
     
     
         29 . The wound closure device of  claim 21 , wherein the plug member includes at least one reactive group that bonds to tissue. 
     
     
         30 . The wound closure device of  claim 29 , wherein the at least one reactive group is selected from the group consisting of isocyanates, N-hydroxy succinimides, cyanoacrylates, aldehydes, genipin, trilysine, tetralysine, polylysines, diimides, diisocyanates, cyanamides, carboiimides, dimethyl adipimidate, starches, and combinations thereof. 
     
     
         31 . The wound closure device of  claim 28 , wherein the mesh is bioabsorbable. 
     
     
         32 . The wound closure device of  claim 29 , wherein the at least one reactive group is provided as a coating. 
     
     
         33 . The wound closure device of  claim 32 , wherein the coating is in dry form. 
     
     
         34 . A wound closure device comprising:
 an elongate body formed from a hydrogel; and   a plug member attached to the elongate body and formed from a mesh including a tissue facing surface defining a diameter that is larger than a diameter of the elongate body.   
     
     
         35 . The wound closure device of  claim 34 , wherein the hydrogel has a grooved exterior surface. 
     
     
         36 . The wound closure device of  claim 34 , wherein the mesh includes at least one reactive group on the tissue facing surface.