Inhibitors of nitric oxide synthase

Abstract

The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP.

1 .- 65 . (canceled) 
     
     
         66 . A method for treatment of septic shock in a human patient suffering from septic shock, comprising administering a biologically effective amount of at least one induction suppressor of inducible nitric oxide synthase to said patient. 
     
     
         67 . The method of  claim 66 , wherein said induction suppressor of inducible nitric oxide synthase is an inhibitor of mevalonate synthesis, an inhibitor of Ras/Raf/MAP kinase pathway, an inhibitor of the farnesylation of Ras, an inhibitor of NF-kβ activation, an antioxidant, an enhancer of intracellular cAMP, an enhancer of protein kinase A (PKA) or a stimulator of AMP-activated protein kinase. 
     
     
         68 . The method of  claim 66 , wherein said induction suppressor of inducible nitric oxide synthase is selected from the group consisting of lovastatin, mevastatin, FPT inhibitor II, forskolin, rolipram, phenylacetate, N-acetyl cysteine, PDTC, 4-phenylbutyrate (4PBA), 5-aminoimmidazole-4-carboxamide ribonucleoside (AICAR), theophylline, papaverine, cAMP, 8-bromo-cAMP and (S)-cAMP. 
     
     
         69 .- 75 . (canceled)