US2014093915A1PendingUtilityA1

Il-18 receptor antigen binding proteins

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Assignee: AMGEN INCPriority: Jul 24, 2007Filed: Sep 3, 2013Published: Apr 3, 2014
Est. expiryJul 24, 2027(~1 yrs left)· nominal 20-yr term from priority
Inventors:Dirk E. SmithJohn E. SimsJeffrey T. McgrewMarek KubinDuncan CochraneLouise Conroy
A61P 3/10A61P 37/02A61P 37/06A61P 31/18A61P 9/00A61P 9/04A61P 43/00A61P 9/10A61P 9/02A61P 37/08A61P 37/00A61P 25/00A61P 29/00A61P 19/02A61P 21/04A61P 17/00A61P 1/16A61P 11/00A61P 1/04A61P 1/00A61P 1/18A61P 17/06A61P 17/02A61P 11/06C07K 2317/76C07K 16/2866C07K 2317/92
55
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Claims

Abstract

Provided herein are IL-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding proteins are also provided. In addition, provided are compositions and methods for diagnosing and treating diseases mediated by IL-18 receptor.

Claims

exact text as granted — not AI-modified
1 - 48 . (canceled) 
     
     
         49 . A nucleic acid encoding a antibody heavy chain variable region of an antigen binding protein that binds the human IL-18 receptor, wherein the antibody heavy chain variable region comprises (a) a CDRH1 of SEQ ID NO: 104; (b) a CDRH2 of SEQ ID NO:105; and (c) a CDRH3 of SEQ ID NO: 106. 
     
     
         50 . The nucleic acid of  claim 49 , wherein the antibody heavy chain variable region comprises the amino acid sequence as set forth in SEQ ID NO:6. 
     
     
         51 . The nucleic acid of  claim 49 , wherein an antibody heavy chain comprises the antibody heavy chain variable region. 
     
     
         52 . The nucleic acid of  claim 51 , wherein the antibody heavy chain comprises the amino acid sequence as set forth in SEQ ID NO:73. 
     
     
         53 . A nucleic acid encoding a antibody light chain variable region of an antigen binding protein that binds the human IL-18 receptor, wherein the antibody light chain variable region comprises (a) a CDRL1 of SEQ ID NO: 173; (b) a CDRL2 of SEQ ID NO:174; and (c) a CDRL3 of SEQ ID NO: 175. 
     
     
         54 . The nucleic acid of  claim 53 , wherein the antibody light chain variable region comprises the amino acid sequence as set forth in SEQ ID NO:29. 
     
     
         55 . The nucleic acid of  claim 53 , wherein an antibody light chain comprises the antibody light chain variable region. 
     
     
         56 . The nucleic acid of  claim 55 , wherein the antibody light chain comprises the amino acid sequence as set forth in SEQ ID NO:75. 
     
     
         57 . The nucleic acid of  claim 49 , further encoding an antibody light chain variable region of an antigen binding protein that binds the human IL-18 receptor, wherein the antibody light chain variable region comprises (a) a CDRL1 of SEQ ID NO: 173; (b) a CDRL2 of SEQ ID NO:174; and (c) a CDRL3 of SEQ ID NO: 175. 
     
     
         58 . The nucleic acid of  claim 50 , further encoding an antibody light chain variable region of an antigen binding protein that binds the human IL-18 receptor, wherein the antibody light chain variable region comprises the amino acid sequence as set forth in SEQ ID NO:29. 
     
     
         59 . The nucleic acid of  claim 52 , further encoding an antibody light chain, wherein the antibody light chain comprises the amino acid sequence as set forth in SEQ ID NO:75. 
     
     
         60 . The nucleic acid of  claim 50 , wherein the nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO:40. 
     
     
         61 . The nucleic acid of  claim 60 , wherein the nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO:74. 
     
     
         62 . The nucleic acid of  claim 54 , wherein the nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO:63. 
     
     
         63 . The nucleic acid of  claim 62 , wherein the nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO:76. 
     
     
         64 . An expression vector comprising a nucleic acid of  claim 49  operably linked to one or more control sequences. 
     
     
         65 . The expression vector of  claim 64 , further comprising a nucleic acid of  claim 53  operably linked to one or more control sequences. 
     
     
         66 . An expression vector comprising a nucleic acid of  claim 53  operably linked to one or more control sequences. 
     
     
         67 . A host cell for producing an antigen binding protein that binds the human IL-18 receptor, wherein said host cell comprises:
 a) a nucleic acid encoding a antibody heavy chain variable region of an antigen binding protein that binds the human IL-18 receptor, wherein the antibody heavy chain variable region comprises (a) a CDRH1 of SEQ ID NO: 104; (b) a CDRH2 of SEQ ID NO:105; and (c) a CDRH3 of SEQ ID NO: 106; and   b) a nucleic acid encoding a antibody light chain variable region of an antigen binding protein that binds the human IL-18 receptor, wherein the antibody light chain variable region comprises (a) a CDRL1 of SEQ ID NO: 173; (b) a CDRL2 of SEQ ID NO:174; and (c) a CDRL3 of SEQ ID NO: 175.   
     
     
         68 . The host cell of  claim 67 , wherein the antibody heavy chain variable region comprises the amino acid sequence as set forth in SEQ ID NO:6. 
     
     
         69 . The host cell of  claim 67 , wherein an antibody heavy chain comprises the antibody heavy chain variable region. 
     
     
         70 . The host cell of  claim 69 , wherein the antibody heavy chain comprises the amino acid sequence as set forth in SEQ ID NO:73. 
     
     
         71 . The host cell of  claim 67 , wherein the antibody light chain variable region comprises the amino acid sequence as set forth in SEQ ID NO:29. 
     
     
         72 . The host cell of  claim 67 , wherein an antibody light chain comprises the antibody light chain variable region. 
     
     
         73 . The host cell of  claim 72 , wherein the antibody light chain comprises the amino acid sequence as set forth in SEQ ID NO:75. 
     
     
         74 . The host cell of  claim 68 , wherein the antibody light chain variable region comprises the amino acid sequence as set forth in SEQ ID NO:29. 
     
     
         75 . The host cell of  claim 70 , wherein the antibody light chain comprises the amino acid sequence as set forth in SEQ ID NO:75. 
     
     
         76 . The host cell of  claim 67 , wherein the nucleic acid encoding an antibody heavy chain variable region comprises the nucleotide sequence set forth in SEQ ID NO:40. 
     
     
         77 . The host cell of  claim 70 , wherein the nucleic acid encoding the antibody heavy chain comprises the nucleotide sequence set forth in SEQ ID NO:74. 
     
     
         78 . The host cell of  claim 67 , wherein the nucleic acid encoding an antibody light chain variable region comprises the nucleotide sequence set forth in SEQ ID NO:63. 
     
     
         79 . The host cell of  claim 73 , wherein the nucleic acid encoding the antibody light chain comprises the nucleotide sequence set forth in SEQ ID NO:76. 
     
     
         80 . The host cell of  claim 67 , wherein the host cell is a mammalian cell. 
     
     
         81 . The host cell of  claim 80 , wherein the mammalian cell is a Chinese hamster ovary (CHO) cell. 
     
     
         82 . A process for preparing an antigen binding protein that binds human IL-18 receptor, the process comprising:
 a) culturing a host cell under suitable conditions to express the antigen binding protein; and   b) isolating the antigen binding protein from the culture of step a), wherein said host cell comprises:
 i) a nucleic acid encoding a antibody heavy chain variable region of an antigen binding protein that binds the human IL-18 receptor, wherein the antibody heavy chain variable region comprises (a) a CDRH1 of SEQ ID NO: 104; (b) a CDRH2 of SEQ ID NO:105; and (c) a CDRH3 of SEQ ID NO: 106; and 
 ii) a nucleic acid encoding a antibody light chain variable region of an antigen binding protein that binds the human IL-18 receptor, wherein the antibody light chain variable region comprises (a) a CDRL1 of SEQ ID NO: 173; (b) a CDRL2 of SEQ ID NO:174; and (c) a CDRL3 of SEQ ID NO: 175.

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