Oral rehydration composition

Abstract

Disclosed are oral rehydration compositions with sucrose, or alternatively fructose and glucose in a 1:1 ratio. The compostion further comprises an osmolarity of below 250 mOsm/L, and sodium below 75 meq/L. Further disclosed are methods of treatment using the same.

1 . An oral rehydration composition, comprising:
 a) at least 40% w/w sucrose;   b) between 1% w/w and 3.5% w/w sodium;   c) between 0.1% w/w chloride and less than 1.5% w/w chloride;   d) potassium, at a level less than 5% w/w;   e) between 15% w/w and 30% w/w citric acid or citrate; and   f) glucose, at a level less than 0.5% w/w;   wherein the composition has a w/w ratio of sodium ions to chloride ions of at least 1.5:1, and wherein, upon mixture with an effective amount of water, the composition has an osmolarity of between 230 mOsm/L and 240 mOsm/L.   
     
     
         2 . (canceled) 
     
     
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         6 . The oral rehydration composition of  claim 1 , comprising about 1400 mmol/L sucrose upon mixture with an effective amount of water. 
     
     
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         12 . The oral rehydration composition of  claim 1 , comprising a ratio of sodium ions to chloride ions of 7:1. 
     
     
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         14 . The oral rehydration composition of  claim 1 , comprising glucose in an amount less than 0.1% w/w. 
     
     
         15 . The oral rehydration composition of  claim 1 , further comprising fructose in an amount less than 20% w/w. 
     
     
         16 . (canceled) 
     
     
         17 . (canceled) 
     
     
         18 . A method of treating or preventing dehydration in a subject in need thereof, comprising administering to the subject a composition of  claim 1 . 
     
     
         19 . The method of  claim 18 , wherein the subject is an athlete or a child. 
     
     
         20 . The method of  claim 18 , wherein the subject is suffering from diarrhea. 
     
     
         21 . The method of  claim 18 , wherein the subject is suffering from cholera. 
     
     
         22 . The method of  claim 18 , wherein the subject is suffering from Short Bowel Syndrome. 
     
     
         23 . The method of  claim 18 , wherein the subject is suffering from dehydration associated with excessive alcohol consumption. 
     
     
         24 . The oral rehydration composition of  claim 1 , comprising less than 3% w/w sodium. 
     
     
         25 . The oral rehydration composition of  claim 1 , comprising less than 20% w/w citric acid or citrate. 
     
     
         26 . The oral rehydration composition of  claim 1 , comprising between 0.1% w/w chloride and 0.7% w/w chloride. 
     
     
         27 . The oral rehydration composition of  claim 1 , comprising between 0.1% w/w chloride and 0.66% w/w chloride.