Hair care compositions and methods of use

Abstract

Hair care compositions including from about 0.005% to about 5% apigenin; from about 0.15% to about 12% of a solubilizing agent, wherein the solubilizing agent comprises an amine functional group; and at least about 20 weight percent of an aqueous carrier, where the composition has a pH ranging from about 3 to about 10, and methods of making the same are provided. These hair care compositions can be applied to any area of the scalp or hair where healthier hair appearance is desired.

1 . A hair care composition comprising:
 a) from about 0.15 wt % to about 5% wt % apigenin;   b) from about 1% to about 12% of a solubilizing agent, wherein the solubilizing agent comprises an amine functional group; and   c) at least 20 weight percent of an aqueous carrier, and   d) from about 0.5 wt % to about 20 wt % of a rheology modifier, wherein the rheology modifier is an acrylate copolymer;   
       wherein the composition has a pH ranging from about 3 to about 10. 
     
     
         2 . The hair care composition of  claim 1 , wherein the solubilizing agent has individual Hansen solubility parameters of a dispersion force component (δ D ) ranging from about 12 to about 22 (MPa) 0.5 , a polar component (δ P ) ranging from about 6.7 to about 20.3 (MPa) 0.5  and a hydrogen bonding component (δ H ) ranging from about 7.1 to about 20.7 (MPa) 0.5 . 
     
     
         3 . The hair care composition of  claim 1 , wherein the solubilizing agent has individual Hansen solubility parameters of a dispersion force component (δ D ) ranging from about 12 to about 22 (MPa) 0.5  and polar and hydrogen bonding components (δ P  and δ H ) falling approximately within a 6.8 (MPa) 0.5  radius around, δ P =13.5 (MPa) 0.5 , δ H =13.9 (MPa) 0.5 . 
     
     
         4 . The hair care composition of  claim 1 , wherein the amine functional group of the solubilizing agent is selected from the group consisting of a primary amine, a secondary amine, a tertiary amine, and an amide. 
     
     
         5 . The hair care composition of  claim 1 , wherein the amine functional group of the solubilizing agent is a tertiary amine. 
     
     
         6 . The hair care composition of  claim 1 , wherein the solubilizing agent further comprises a hydroxyl functional group. 
     
     
         7 . The hair care composition of  claim 1 , wherein the solubilizing agent is selected from the group consisting of 2-dimethylaminoethanol, 1-dimethylamino-2-propanol, triethanolamine, ethylenediamine, diethanolamine, ethanolamine, 2-amino-2-methyl-1-propanol, dimethyl capramide and combinations thereof. 
     
     
         8 . The hair care composition of  claim 1 , wherein the solubilizing agent is triethanolamine. 
     
     
         9 . The hair care composition of  claim 1 , further comprising a plurality of solubilizing agents. 
     
     
         10 . The hair care composition of any preceding claim further comprising a conditioning agent, a moisturizing agent, a penetrant agent, an organic solvent, a neutralizing agent, a surfactant, a fragrance agent, an aesthetics enhancer, a partitioning enhancer, or combinations thereof. 
     
     
         11 . The hair care composition of  claim 10 , wherein the conditioning agent is present in an amount within the range from about 0.1 wt % to about 5 wt %; the moisturizing agent is present in an amount within the range from about 0.5 wt % to about 5 wt %; the penetrant agent is present in an amount within the range from about 0.05 wt % to about 10 wt %; the organic solvent is present is present in an amount within the range from about 0.5 wt % to about 50 wt %; the neutralizing agent is present in an amount within the range from about 0.1 wt % to about 10 wt the surfactant is present in an amount within the range from about 0.1 wt % to about 20 wt %; the fragrance agent is present in an amount within the range from about 0.1 wt % to about 3 wt %, the aesthetics enhancer is present in an amount ranging from about 0.1 wt % to about 3 wt %, or the partitioning agent is present in an amount ranging from about 0.1 wt % to about 10 wt %, wherein the wt % is based on the total weight percent of the hair composition. 
     
     
         12 . The hair care composition of  claim 1 , further comprising a xanthine compound, a vitamin B 3  compound, a panthenol compound, or mixtures thereof. 
     
     
         13 . The hair care composition of  claim 12 , wherein the xanthine compound is present in an amount ranging from about 0.1 wt % to about 10 wt %; the vitamin B 3  compound is present in an amount ranging from about 0.1 wt % to about 25 wt %; or the panthenol compound is present in an amount ranging from about 0.01 wt % to about 3 wt %, wherein weight percent is based on the total weight of the hair composition. 
     
     
         14 . A process for preparing a hair care composition comprising:
 a) mixing apigenin and a solubilizing agent at a temperature sufficient to allow dissolution of the apigenin in the solubilizing agent to form a premixture, wherein the weight ratio of apigenin to the solubilizing agent ranges from about 1:50 to about 1:4;   b) combining the premixture with an aqueous carrier to form the hair care composition; and   c) optionally, adjusting a pH of the hair care composition with an acid to within a range from about 3 to about 10.   
     
     
         15 . The process of  claim 13 , wherein the weight ratio of apigenin to the solubilizing agent is within the range from about 1:10 to about 1:4. 
     
     
         16 . The process of  claim 14 , further comprising
 d) adding a rheology modifier to the hair care composition to obtain a rheology value in the range from about 30 cPs to about 50,000 cPs.   
     
     
         17 . The process of  claim 16 , wherein the rheology value is in the range from about 300 to about 5,000 cPs. 
     
     
         18 . The process of  claim 16 , wherein the rheology modifier is selected from the group consisting of hydroxypropylmethylcellulose; a mixture of acrylamide/ammonium acrylate copolymer, polyisobutene, and polysorbate 20; acrylamide/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate 80; acrylates copolymer; acrylates/beheneth-25 methacrylate copolymer; acrylates/C10-C30 alkyl acrylate crosspolymer; acrylates/steareth-20 itaconate copolymer; ammonium polyacrylate/Isohexadecane/PEG-40 castor oil; C12-16 alkyl PEG-2 hydroxypropylhydroxyethyl ethylcellulose (HM-EHEC); carbomer; crosslinked polyvinylpyrrolidone (PVP); dibenzylidene sorbitol; hydroxyethyl ethylcellulose (EHEC); hydroxypropyl methylcellulose (HPMC); hydroxypropyl methylcellulose (HPMC); hydroxypropylcellulose (HPC); methylcellulose (MC); methylhydroxyethyl cellulose (MEHEC); PEG-150/decyl alcohol/SMDI copolymer; PEG-150/stearyl alcohol/SMDI copolymer; polyacrylamide/C13-14 isoparaffin/laureth-7; polyacrylate 13/polyisobutene/polysorbate 20; polyacrylate crosspolymer-6; polyamide-3; polyquaternium-37 (and) hydrogenated polydecene (and) trideceth-6; polyurethane-39; sodium acrylate/acryloyldimethyltaurate/dimethylacrylamide; crosspolymer (and) isohexadecane (and) polysorbate 60; sodium polyacrylate and combinations thereof. 
     
     
         19 . The process of  claim 14 , wherein the pH of the hair care composition is adjusted with an acid to within a range from about 6.5 to about 9, and optionally wherein the acid is citric acid or hydrochloric acid 
     
     
         20 . A method of affecting a healthier hair appearance comprising the steps of:
 administering an effective amount of the hair care composition of any  claim 1 - 12  to at least one first portion of a scalp of said subject,   
       wherein the healthier hair appearance includes treating hair loss in a subject in need of such treatment, delaying the appearance of gray mammalian hair of a subject, or increasing the appearance of fuller and thicker mammalian hair of a subject.