US2014080845A1PendingUtilityA1

Use of allopurinol for the treatment of hand foot skin reaction

41
Assignee: RODEMER YOLANDAPriority: Apr 29, 2009Filed: Nov 22, 2013Published: Mar 20, 2014
Est. expiryApr 29, 2029(~2.8 yrs left)· nominal 20-yr term from priority
Inventors:Yolanda Rodemer
A61P 29/00A61P 25/00A61P 27/00A61P 17/16A61P 17/00A61P 17/12A61P 17/02A61K 31/519A61K 9/0014A61K 9/06A61K 2121/00A61K 31/52
41
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Claims

Abstract

Use of allopurinol or a pharmaceutically acceptable salt thereof for the treatment or prevention of Hand Foot Skin Reaction (HFSR) induced by Multitargeted Kinase Inhibitor (MKI) therapy. The allopurinol or its salt is administered topically to the affected areas, palms and soles, preferably in the form of a cream.

Claims

exact text as granted — not AI-modified
1 - 10 . (canceled) 
     
     
         11 . A method for preventing Hand Foot Skin Reaction (HFSR) induced by Multitargeted Kinase (MKI) therapy in a patient in need thereof, comprising administering to the patient a medicament having an amount of allopurinol or a pharmaceutically acceptable salt thereof which is therapeutically effective to prevent Hand Foot Skin Reaction. 
     
     
         12 . The method according to  claim 11 , wherein the HFSR is induced by sorafenib. 
     
     
         13 . The method according to  claim 11 , wherein the HFSR is induced by sunitinib. 
     
     
         14 . The method according to  claim 11 , wherein the medicament is administered topically to the skin. 
     
     
         15 . The method according to  claim 14 , wherein the medicament is administered topically to the skin of the hands or feet. 
     
     
         16 . The method according to  claim 11 , wherein the medicament is a cream. 
     
     
         17 . The method according to  claim 16 , wherein the medicament is a hydrophilic cream. 
     
     
         18 . The method according to  claim 11 , wherein the medicament comprises from about 1% to about 10% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         19 . The method according to  claim 18 , wherein the medicament comprises from about 1% to about 5% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         20 . The method according to  claim 19 , wherein the medicament comprises about 3% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         21 . The method according to  claim 12 , wherein the medicament is administered topically to the skin of the hands or feet. 
     
     
         22 . The method according to  claim 13 , wherein the medicament is administered topically to the skin of the hands or feet. 
     
     
         23 . The method according to  claim 12 , wherein the medicament comprises from about 1% to about 10% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         24 . The method according to  claim 13 , wherein the medicament comprises from about 1% to about 10% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         25 . The method according to  claim 15 , wherein the medicament comprises from about 1% to about 10% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         26 . The method according to  claim 25 , wherein the medicament comprises from about 1% to about 5% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         27 . The method according to  claim 26 , wherein the medicament comprises about 3% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         28 . The method according to  claim 23 , wherein the medicament comprises from about 1% to about 5% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof. 
     
     
         29 . The method according to  claim 24 , wherein the medicament comprises from about 1% to about 5% by weight of the composition of allopurinol or a pharmaceutically acceptable salt thereof.

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