Pharmaceutical preparations containing highly volatile silicones

Abstract

The subject of the present invention is a transdermal preparation containing pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. The volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclo-siloxane. A further subject of the present invention is a method for the preparation of such pharmaceutical compositions.

What is claimed is: 
     
         1 . A transdermal preparation containing a pharmaceutically active ingredient, wherein the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof, and these coated particles are dispersed in a gel or cream base. 
     
     
         2 . A composition according to  claim 1 , characterized in that the active ingredient is acyclovir, piroxicam, meloxicam, ibuprofen, diclofenac sodium or diclofenac potassium, clotrimazole, bifonazole, metronidazole, nifedipine, glycerol trinitrate or cetirizine. 
     
     
         3 . A composition according to  claim 1 , characterized in that the volatile silicone component is hexamethyldisiloxane and/or octamethyltrisiloxane and/or decamethylpentacyclosiloxane. 
     
     
         4 . A composition according to  claim 1 , characterized in that the cream base is carboxyvinyl polymer, hydroxypropyl-methylcellulose or mixtures thereof. 
     
     
         5 . A process for the preparation of the composition according to  claim 1 , characterized in that the particles of the active ingredient are coated with highly volatile silicones or a mixture thereof and the obtained mixture is distributed in a gel or cream base, thus the particles in the gel or cream base are surrounded with silicone coating.