US2014073761A1PendingUtilityA1

Conjugates containing hydrophilic spacer linkers

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Assignee: ENDOCYTE INCPriority: Jun 25, 2007Filed: Mar 5, 2013Published: Mar 13, 2014
Est. expiryJun 25, 2027(~0.9 yrs left)· nominal 20-yr term from priority
Inventors:Christopher Paul LeamonIontcho Radoslavov VlahovHari Krishna R. SanthapuramPaul Joseph KleindlKevin Yu WangFei You
A61P 33/10A61P 31/04A61P 31/10A61P 35/00A61P 35/02A61P 31/12A61P 33/02A61P 33/04A61P 33/00A61P 31/00A61K 47/545C07K 9/003C07H 15/24A61K 47/60A61K 47/65A61K 47/4813A61K 47/48338
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Claims

Abstract

Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.

Claims

exact text as granted — not AI-modified
1 . A compound of the formula
   B-L-A   
       wherein B is a receptor binding ligand that binds to a target cell receptor, L is a linker that comprises one or more hydrophilic spacer linkers, and A is a diagnostic, therapeutic, or imaging agent that is desirably delivered to the cell. 
     
     
         2 .- 39 . (canceled)

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