US2014066594A1PendingUtilityA1

Binding ligand linked drug delivery conjugates of tubulysins

54
Assignee: ENDOCYTE INCPriority: Mar 14, 2007Filed: Mar 5, 2013Published: Mar 6, 2014
Est. expiryMar 14, 2027(~0.6 yrs left)· nominal 20-yr term from priority
Inventors:Iontcho Radoslavov VlahovChristopher Paul LeamonKevin Yu Wang
A61P 43/00A61K 47/551C07K 5/021C07K 5/06078A61K 47/6811C07K 7/06A61K 51/0497A61K 47/55A61K 47/64A61P 35/00A61K 47/65
54
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Claims

Abstract

Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations. The compounds described herein include conjugates of tubulysins and vitamin receptor binding ligands. The conjugates also include a releasable bivalent linker.

Claims

exact text as granted — not AI-modified
1 . A drug delivery conjugate of the formula
   B-L-D   
       wherein B is a binding or targeting ligand, L is a releasable linker, and D is a tubulysin. 
     
     
         2 - 36 . (canceled)

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