US2014065169A1PendingUtilityA1

Methods of Treating Acute Myeloid Leukemia by Blocking CD47

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Assignee: UNIV LELAND STANFORD JUNIORPriority: Jan 15, 2008Filed: Jul 12, 2013Published: Mar 6, 2014
Est. expiryJan 15, 2028(~1.5 yrs left)· nominal 20-yr term from priority
Inventors:Siddhartha JaiswalIrving L. WeissmanRavindra MajetiMark P. Chao
A61P 43/00A61P 35/00A61P 35/02A61P 25/00A61P 15/00A61P 13/10G01N 33/57505A61K 47/6863C07K 16/3046A61K 47/6867A61K 47/6851A61K 2039/505A61K 47/6861C07K 16/2896C07K 16/2803A61K 39/39558C07K 2317/31C07K 16/3069C07K 16/3038A61K 2039/507A61K 47/6869C07K 16/30C07K 16/3061C07K 2317/76C07K 2317/73C07K 16/18A61K 47/6865C07K 16/3053G01N 2500/04C12N 5/0694C12N 5/0093C07K 2317/24C12Q 2600/136C07K 16/28C07K 2317/75C12Q 1/6886G01N 33/5011C12Q 2600/112
67
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Claims

Abstract

Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.

Claims

exact text as granted — not AI-modified
1 - 15 . (canceled) 
     
     
         16 . A method of treating a human subject having a hematopoietic cancer, the method comprising:
 administering to the human subject an antibody that prevents the binding of CD47 with SIRPα, at a dose that achieves a depletion in hematopoietic cancer cells.   
     
     
         17 . The method of  claim 16 , wherein the hematopoietic cancer is a leukemia or a lymphoma. 
     
     
         18 . The method of  claim 17 , wherein the leukemia is an acute leukemia. 
     
     
         19 . The method of  claim 18 , wherein the acute leukemia is AML (acute myeloid leukemia). 
     
     
         20 . The method of  claim 18 , wherein the acute leukemia is an ALL (acute lymphocytic leukemia). 
     
     
         21 . The method of  claim 20 , wherein the ALL is T-ALL (T-cell ALL). 
     
     
         22 . The method of  claim 20 , wherein the ALL is B-ALL (B-cell ALL). 
     
     
         23 . The method of  claim 17 , wherein the lymphoma is non-Hodgkins lymphoma. 
     
     
         24 . The method of  claim 23 , wherein the lymphoma is DLBCL (diffuse large B-cell lymphoma). 
     
     
         25 . The method of  claim 23 , wherein the lymphoma is Hodgkins lymphoma.

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