Method of judging inflammatory disease by using single nucleotide polymorphism

Abstract

An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and the advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging an inflammatory disease which comprises detecting at least 1 type of genetic polymorphism existing in at least one gene selected from the group consisting of the LBP-32 gene, the TSBP gene, and the WAP gene.

1 . A method of determining a susceptibility to myocardial infarction in a human individual, comprising:
 analyzing a biological sample from a human individual who has not had a myocardial infarction for the presence or absence of any one of the following alleles, and   determining an increased susceptibility to myocardial infarction for the individual when any one of the following alleles is present in the biological sample, or determining a decreased susceptibility to myocardial infarction for the individual when any one of the following alleles is absent from the biological sample:   (1) allele A at nucleotide 151 in the nucleotide sequence of intron 1 of an LBP-32 gene;   (2) allele G at nucleotide 306 in the nucleotide sequence of exon 25 of a TSBP gene; and   (3) allele A at nucleotide 1264 in the nucleotide sequence of the 3′ flanking region of a WAP12 gene.