Piroxicam-containing matrix patches and methods for the topical treatment of acute and chronic pain and inflammation therewith

Abstract

This invention relates to matrix patches for the topical (i.e., transdermal) delivery of piroxicam and methods for the treatment of acute and chronic pain and inflammation therewith, particularly pain and inflammation caused by sports injuries or other muscle aches or injuries requiring the application of analgesic and/or anti-inflammation medication, in this instance, piroxicam.

1 - 90 . (canceled) 
     
     
         91 . A method of treating a condition associated with acute and chronic pain and/or inflammation, wherein said method comprises applying a matrix patch for topical administration of piroxicam to a subject,
 wherein said matrix patch consists of a removable covering layer, a compatible backing layer, and a piroxicam-containing self-adhesive matrix layer in between wherein the self-adhesive matrix layer includes a pharmaceutically effective amount of piroxicam in an acrylic copolymer self-adhesive base, wherein said base further includes petrolatum, polyvinylpyrrolidone, and either dimethyl isosorbide and/or a monoalkyl ether of diethylene glycol.   
     
     
         92 . The method according to  claim 91 , wherein said condition is selected from the group consisting of rheumatoid arthritis, osteoarthritis, inflammatory arthropathies, gout and pseudogout, dysmenorrhea, metastatic bone pain, headache and migraine, postoperative pain, post-herpetic neuralgia, neuropathic pains, sports injuries, soft-tissue injuries, strains, sprains, contusions, tendonitis or bursitis of the shoulder, elbow, wrist or knee, Carpal tunnel syndrome, lateral epicondylosis, low back pains and injury. 
     
     
         93 . A method of treating a condition associated with acute and chronic pain and/or inflammation, wherein said method comprises applying a matrix patch for topical administration of piroxicam to a subject,
 wherein said matrix patch consists of a removable covering layer, a compatible backing layer, and a piroxicam-containing self-adhesive matrix layer in between wherein the self-adhesive matrix layer consists essentially of a pharmaceutically effective amount of piroxicam in an acrylic copolymer self-adhesive base, wherein said base further includes petrolatum, polyvinylpyrrolidone, and dimethyl isosorbide.   
     
     
         94 . The method according to  claim 93 , wherein said condition is selected from the group consisting of rheumatoid arthritis, osteoarthritis, inflammatory arthropathies, gout and pseudogout, dysmenorrhea, metastatic bone pain, headache and migraine, postoperative pain, post-herpetic neuralgia, neuropathic pains, sports injuries, soft-tissue injuries, strains, sprains, contusions, tendonitis or bursitis of the shoulder, elbow, wrist or knee, Carpal tunnel syndrome, lateral epicondylosis, low back pains and injury. 
     
     
         95 . A method of treating a condition associated with acute and chronic pain and/or inflammation, wherein said method comprises applying a matrix patch for topical administration of piroxicam to a subject,
 wherein said matrix patch consists of a removable covering layer, a compatible backing layer, and a piroxicam-containing self-adhesive matrix layer in between wherein the self-adhesive matrix layer consists essentially of a pharmaceutically effective amount of piroxicam in an acrylic copolymer self-adhesive base, wherein said base further includes petrolatum, polyvinylpyrrolidone, and monoethyl ether of diethylene glycol.   
     
     
         96 . The method according to  claim 95 , wherein said condition is selected from the group consisting of rheumatoid arthritis, osteoarthritis, inflammatory arthropathies, gout and pseudogout, dysmenorrhea, metastatic bone pain, headache and migraine, postoperative pain, post-herpetic neuralgia, neuropathic pains, sports injuries, soft-tissue injuries, strains, sprains, contusions, tendonitis or bursitis of the shoulder, elbow, wrist or knee. Carpal tunnel syndrome, lateral epicondylosis, low back pains and injury. 
     
     
         97 . A method of treating a condition associated with acute and chronic pain and/or inflammation, wherein said method comprises applying a matrix patch for topical administration of piroxicam to a subject,
 wherein said matrix patch consists of a removable covering layer, a compatible backing layer, and a piroxicam-containing self-adhesive matrix layer in between wherein the self-adhesive matrix layer includes a pharmaceutically effective amount of piroxicam in an acrylic copolymer self-adhesive base, wherein said base further includes petrolatum, polyvinylpyrrolidone, a solvent, and either dimethyl isosorbide or a monoalkyl ether of diethylene glycol.   
     
     
         98 . The method according to  claim 97 , wherein said condition is selected from the group consisting of rheumatoid arthritis, osteoarthritis, inflammatory arthropathies, gout and pseudogout, dysmenorrhea, metastatic bone pain, headache and migraine, postoperative pain, post-herpetic neuralgia, neuropathic pains, sports injuries, soft-tissue injuries, strains, sprains, contusions, tendonitis or bursitis of the shoulder, elbow, wrist or knee, Carpal tunnel syndrome, lateral epicondylosis, low back pains and injury.